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Research Grade Crizanlizumab

Catalog #:   DHD15101 Specific References (94) DATASHEET
Host species: Humanized
Isotype: IgG2-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD15101

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

Leukocyte-endothelial cell adhesion molecule 3, Platelet activation dependent granule-external membrane protein, Granule membrane protein 140, GMP-140, CD62P, SELP, GRMP, PADGEM, CD62 antigen-like family member P, LECAM3, P-selectin, GMRP

Concentration

6.06 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16109

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

SelG1, CAS: 1690318-25-2

Clone ID

Crizanlizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Crizanlizumab
  • Bioactivity
    Detects CD62P/SELP in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease, PMID: 27959701

Crizanlizumab: First Approval, PMID: 31933169

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis, PMID: 30295335

Crizanlizumab, PMID: 32401467

Systematic Review of Crizanlizumab: A New Parenteral Option to Reduce Vaso-occlusive Pain Crises in Patients with Sickle Cell Disease, PMID: 32350885

Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis, PMID: 32948541

Antibodies to watch in 2020, PMID: 31847708

Crizanlizumab, PMID: 34406730

Crizanlizumab in vaso-occlusive crisis caused by sickle cell disease, PMID: 33332478

Efficacy and safety of recently approved drugs for sickle cell disease: a review of clinical trials, PMID: 32841705

The vaso-occlusive pain crisis in sickle cell disease: Definition, pathophysiology, and management, PMID: 32301178

Antibodies to watch in 2019, PMID: 30516432

Crizanlizumab in Sickle Cell Disease, PMID: 28467874

Drug Therapies for the Management of Sickle Cell Disease, PMID: 32765834

Crizanlizumab in Sickle Cell Disease, PMID: 28467873

Crizanlizumab Prevents Sickle Cell Pain Crises, PMID: 28245319

Current and novel therapies for the prevention of vaso-occlusive crisis in sickle cell disease, PMID: 33062233

Challenges in the Management of Sickle Cell Disease During SARS-CoV-2 Pandemic, PMID: 32873056

Profile of crizanlizumab and its potential in the prevention of pain crises in sickle cell disease: evidence to date, PMID: 31507334

Severe infusion-related reaction to crizanlizumab in an adolescent with sickle cell disease, PMID: 32945013

Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment, PMID: 32208292

The European Medicines Agency Review of Crizanlizumab for the Prevention of Recurrent Vaso-Occlusive Crises in Patients With Sickle Cell Disease, PMID: 34235401

P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab, PMID: 33833562

More Unnecessary Imaginary Worlds - Part 4: The ICER Evidence Report for Crizanlizumab, Voxelotor and L-Glutamine for Sickle Cell Disease, PMID: 34007618

P-selectin blockade in COVID-19-related ARDS, PMID: 32464083

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease, PMID: 31934320

Two drugs for sickle cell disease, PMID: 32324178

Sickle Cell Disease: Advances in Treatment, PMID: 30559624

What are the key considerations when prescribing pharmacotherapy for sickle cell anemia?, PMID: 32955945

Managing patients with sickle cell disease in primary care, PMID: 32941305

Two New Drugs for Sickle Cell Disease, PMID: 32079792

Treating sickle cell anemia: A new era dawns, PMID: 31925819

Emerging pharmacotherapeutic approaches for the management of sickle cell disease, PMID: 30499731

Advances in Sickle Cell Disease Treatments, PMID: 32520675

Innovative Treatments for Rare Anemias, PMID: 34095760

Antibodies to watch in 2018, PMID: 29300693

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease, PMID: 31977004

Novartis snaps up Selexys for sickle cell, PMID: 28178263

Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review, PMID: 29296801

Research in Sickle Cell Disease: From Bedside to Bench to Bedside, PMID: 34095767

Curative vs targeted therapy for SCD: does it make more sense to address the root cause than target downstream events?, PMID: 32722787

Contemporary Management and Prevention of Vaso-Occlusive Crises (VOCs) in Adults With Sickle Cell Disease, PMID: 34151636

Elevated P-Selectin in Severe Covid-19: Considerations for Therapeutic Options, PMID: 33747397

Review of Medication Therapy for the Prevention of Sickle Cell Crisis, PMID: 30013299

Antiplatelet agents for preventing vaso-occlusive events in people with sickle cell disease: a systematic review, PMID: 31188815

Sickle cell vaso-occlusion: The dialectic between red cells and white cells, PMID: 33794696

ADORE: an open platform study of ruxolitinib in combination with other novel therapies in patients with myelofibrosis., PMID:40334082

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies., PMID:40307078

Clinically relevant clot resolution via a thromboinflammation-on-a-chip., PMID:40175551

Impact of Different Definitions of Vaso-Occlusion on Efficacy Assessments in Sickle Cell Disease Clinical Trials., PMID:40146367

Now where do we STAND with crizanlizumab?, PMID:40088923

Crizanlizumab with or without hydroxyurea in patients with sickle cell disease (STAND): primary analyses from a placebo-controlled, randomised, double-blind, phase 3 trial., PMID:40088922

Accelerated drug approvals and patient trust: impact of voxelotor and crizanlizumab for sickle cell disease., PMID:40085957

A critique review of fetal hemoglobin modulators through targeting epigenetic regulators for the treatment of sickle cell disease., PMID:40057227

A review on disease modifying pharmacologic therapies for sickle cell disease., PMID:39828781

A contemporary review of the management strategies for sickle cell disease related ischaemic and stuttering priapism., PMID:39709509

Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study., PMID:39680465

Practical guide for disease-modifying medication management of children and adolescents with sickle cell disease., PMID:39644011

Novel Pathway and Recent Advances for Targeting Sickle Cell Anemia through Novel Drug Delivery System., PMID:39629577

Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition., PMID:39568425

Promising role of voxelotor in managing sickle cell disease in children: a narrative review., PMID:39533724

The Current Role of Hydroxyurea in the Treatment of Sickle Cell Anemia., PMID:39518543

Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease: final results from the phase II SOLACE-adults study., PMID:39497751

Real-World Evidence of Crizanlizumab Showing Reductions in Vaso-Occlusive Crises and Opioid Usage in Sickle Cell Disease., PMID:39473076

Gene Therapies for Sickle Cell Disease., PMID:39391326

Advancing life: innovative approaches to enhance survival in sickle cell anemia patients., PMID:39359845

Newer Modalities and Updates in the Management of Sickle Cell Disease: A Systematic Review., PMID:39286637

Budget Impact of Disease-Modifying Treatments and a CRISPR Gene-Edited Therapy for Sickle Cell Disease., PMID:39134876

Exploring the genetic mechanisms: SELP gene's contribution to alleviating vaso-occlusive crisis in sickle cell disease., PMID:39079562

Current and emerging drug treatment strategies to tackle sickle cell anemia., PMID:38988318

The enigma of sickle cell hepatopathy: Pathophysiology, clinical manifestations and therapy., PMID:38978231

Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study., PMID:38950286

Potential efficacy of crizanlizumab in treating priapism in sickle cell disease: A case report., PMID:38736574

Clinical Practice Patterns in Sickle Cell Disease Treatment: Disease-modifying and Potentially Curative Therapies., PMID:38718300

Cost-effectiveness of l-glutamine versus crizanlizumab for adults with sickle cell disease: model focused on reducing pain episode costs from Qatar's healthcare perspective., PMID:38711465

Sickle Cell Disease in Brazil: Current Management., PMID:38663998

Expert consensus on the management of infusion-related reactions (IRRs) in patients with sickle cell disease (SCD) receiving crizanlizumab: a RAND/UCLA modified Delphi panel., PMID:38642304

Spanish registry of hemoglobinopathies and rare anemias (REHem-AR): demographics, complications, and management of patients with β-thalassemia., PMID:38519604

Plant-Produced Therapeutic Crizanlizumab Monoclonal Antibody Binds P-Selectin to Alleviate Vaso-occlusive Pain Crises in Sickle Cell Disease., PMID:38491245

Crizanlizumab and sickle cell disease: When should medications have their approval status revoked?, PMID:38409818

Recurrent Nontraumatic Subgaleal Hematomas in a Pediatric Patient With Sickle Cell Disease., PMID:38408160

An update review of new therapies in sickle cell disease: the prospects for drug combinations., PMID:38344818

Casgevy and Lyfgenia: Two gene therapies for sickle cell disease., PMID:38212256

Real-world experience of patients with sickle cell disease treated with crizanlizumab., PMID:38073007

Using disease-modifying therapies in sickle cell disease., PMID:38066905

Use of Disease-Modifying Treatments in Patients With Sickle Cell Disease., PMID:37991760

Red Blood Cells as Therapeutic Target to Treat Sickle Cell Disease., PMID:37975291

Comparative pharmacovigilance assessment of adverse events associated with the use of hydroxyurea, L-glutamine, voxelotor, and crizanlizumab in sickle cell disease., PMID:37950855

Sickle cell disease: combination new therapies vs. CRISPR-Cas9 potential and challenges - review article., PMID:37867187

Crizanlizumab in sickle cell disease., PMID:37850353

Successful Treatment of SCD-Related Priapism With Crizanlizumab: A Case Series., PMID:37731262

Advancements in Sickle Cell Disease (SCD) Treatment: A Review of Novel Pharmacotherapies and Their Impact on Patient Outcomes., PMID:37664319

The Role of Non-genetic Therapies to Reduce the Incidence of Sickle Cell Crisis: A Systematic Review., PMID:37664256

P-Selectin de-ACTIVation in COVID-19: What Have We Learned?, PMID:37523764

Datasheet

Document Download

Research Grade Crizanlizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Crizanlizumab [DHD15101]
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