Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Research Biosimilar

Research Grade Moxetumomab

Catalog #:   DHD38501 Specific References (98) DATASHEET
Host species: Mouse
Isotype: scFv-His
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD38501

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Mouse

Isotype

scFv-His

Clonality

Monoclonal

Target

Sialic acid-binding Ig-like lectin 2, Siglec-2, CD22, T-cell surface antigen Leu-14, BL-CAM, SIGLEC2, B-lymphocyte cell adhesion molecule, B-cell receptor CD22

Concentration

0.85mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P20273

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAT-8015, GCR-8015, HA22, moxetumomab pasudotox -tdfk, CAS: 1020748-57-5

Clone ID

Moxetumomab

Data Image
  • SDS-PAGE
    SDS PAGE for Moxetumomab
References

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia, PMID: 30030507

Moxetumomab Pasudotox: First Global Approval, PMID: 30357593

Moxetumomab Pasudotox, PMID: 31644208

Moxetumomab pasudotox for the treatment of hairy cell leukemia, PMID: 31045462

Moxetumomab Pasudotox, PMID: 30371998

Moxetumomab Pasudotox: Clinical Experience in Relapsed/Refractory Hairy Cell Leukemia, PMID: 31099793

Moxetumomab pasudotox-tdfk for relapsed/refractory hairy cell leukemia: a review of clinical considerations, PMID: 31134324

Moxetumomab pasudotox: A first-in-class treatment for hairy cell leukemia, PMID: 30917739

Moxetumomab pasudotox for the treatment of relapsed and/or refractory hairy cell leukemia, PMID: 31298972

Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval, PMID: 31594764

Hairy cell leukemia: present and future directions, PMID: 31068044

Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss, PMID: 32534028

[Hairy cell leukemia], PMID: 31447330

Correction to: Moxetumomab Pasudotox: First Global Approval, PMID: 30612318

Treatment of hairy cell leukemia, PMID: 32893700

Moxetumomab Pasudotox in Hairy Cell Leukaemia: A Profile of Its Use, PMID: 34383256

Update on hairy cell leukemia, PMID: 29742076

Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox, PMID: 22003067

Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia, PMID: 31628266

Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia, PMID: 32077130

Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia, PMID: 31944549

Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up, PMID: 29487070

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia, PMID: 28983018

A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains, PMID: 31676342

Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia, PMID: 28449314

5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox, PMID: 29432154

Pharmacokinetic and pharmacodynamic comparability study of moxetumomab pasudotox, an immunotoxin targeting CD22, in cynomolgus monkeys, PMID: 23090886

Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial, PMID: 33627164

Moxetumomab pasudotox as re-treatment for heavily-pretreated relapsed hairy cell leukemia, PMID: 34030585

Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction, PMID: 32959985

A phase I study of moxetumomab pasudotox in adults with relapsed or refractory B-cell acute lymphoblastic leukaemia, PMID: 28616864

Collateral Damages by Magic Bullets: Hemolytic Uremic and Capillary Leak Syndromes After Moxetumomab Pasudotox Therapy, PMID: 31233704

An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox, PMID: 27220271

Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia, PMID: 22355053

Development of Recombinant Immunotoxins for Hairy Cell Leukemia, PMID: 32756468

Immunotoxin Screening System: A Rapid and Direct Approach to Obtain Functional Antibodies with Internalization Capacities, PMID: 33076544

Vemurafenib and Rituximab in Patients with Hairy Cell Leukemia Previously Treated with Moxetumomab Pasudotox, PMID: 34202156

Immunoconjugates in the management of hairy cell leukemia, PMID: 26614902

The pharmacological management of hairy cell leukemia, PMID: 32378970

Critical Issues in the Development of Immunotoxins for Anticancer Therapy, PMID: 31669121

Hairy cell leukemia-new genes, new targets, PMID: 23892906

Hairy Cell Leukemia Treatment Approved, PMID: 30262591

How I manage patients with hairy cell leukaemia, PMID: 28146266

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4), PMID: 29572070

Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma, PMID: 31500657

Potential breakthroughs with investigational drugs for hairy cell leukemia, PMID: 26329588

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation, PMID: 32695104

No Loose Ends: A Review of the Pharmacotherapy of Hairy Cell and Hairy Cell Leukemia Variant, PMID: 30841702

Novel therapeutic options for relapsed hairy cell leukemia, PMID: 25563425

New monoclonal antibodies for the treatment of acute lymphoblastic leukemia, PMID: 27521873

Hairy cell leukemia variant and WHO classification correspondence Re: 5th edition WHO classification haematolymphoid tumors: lymphoid neoplasms., PMID:38851853

Unusual presentation of gastric cancer during treatment of hairy cell leukemia: Exploring the etiological basis of this rare phenomenon., PMID:38328399

Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system., PMID:38100054

Hairy Cell Leukemia: Where Are We in 2023?, PMID:37097545

Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial., PMID:37059834

Refractory and relapsed hairy-cell leukemia (HCL): casting light on promising experimental drugs in clinical trials., PMID:36931901

Novel targeted treatments in hairy cell leukemia and other hairy cell-like disorders., PMID:36620555

Consensus opinion from an international group of experts on measurable residual disease in hairy cell leukemia., PMID:36509740

Measurable residual disease in hairy cell leukemia: Technical considerations and clinical significance., PMID:36439497

Dabrafenib plus trametinib in patients with relapsed/refractory BRAF V600E mutation-positive hairy cell leukemia., PMID:36108341

Selecting appropriate therapy for hairy cell leukemia: current state and future prospects based on molecularly defined characterization., PMID:35703589

Updates in hairy cell leukemia (HCL) and variant-type HCL (HCL-V): rationale for targeted treatments with a focus on ibrutinib., PMID:35450208

Hairy Cell Leukemia (HCL) and HCL Variant: Updates and Spotlights on Therapeutic Advances., PMID:35403971

Advances in the Treatment of Hairy Cell Leukemia Variant., PMID:35178674

How I treat refractory/relapsed hairy cell leukemia with BRAF inhibitors., PMID:35143639

Splicing-Mediated Antigen Escape from Immunotherapy for B-cell Malignancies., PMID:35015686

Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin., PMID:34976821

[Moxetumomab pasudotox-Third line in Hairy cell leukemia]., PMID:34776118

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments., PMID:34638774

Diagnosis and treatment of hairy cell leukemia as the COVID-19 pandemic continues., PMID:34535326

Moxetumomab Pasudotox in Hairy Cell Leukaemia: A Profile of Its Use., PMID:34383256

Management of Relapsed Hairy Cell Leukemia: A Systematic Review of Novel Agents and Targeted Therapies., PMID:34275772

Hairy cell leukemia: a brief update on current knowledge and treatment prospects., PMID:34264896

Vemurafenib and Rituximab in Patients with Hairy Cell Leukemia Previously Treated with Moxetumomab Pasudotox., PMID:34202156

Moxetumomab pasudotox as re-treatment for heavily-pretreated relapsed hairy cell leukemia., PMID:34030585

[Hairy cell leukemia: What are the best treatment options for relapsed or refractory patients?]., PMID:34023063

Hairy cell leukemia and COVID-19 adaptation of treatment guidelines., PMID:33947938

Expert's views and perspectives: an interview with distinguished investigator Dr. Ira Pastan at the National Cancer Institute at NIH., PMID:33928228

Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies., PMID:33807678

Phase 2 study of ibrutinib in classic and variant hairy cell leukemia., PMID:33754642

Lytic Bone Lesion: An Unusual Presentation of Hairy Cell Leukemia., PMID:33659114

Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial., PMID:33627164

Hairy Cell Leukaemia: From Hairy Beginnings to a BRAF New World., PMID:33190264

Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction., PMID:32959985

Treatment of hairy cell leukemia., PMID:32893700

Development of Recombinant Immunotoxins for Hairy Cell Leukemia., PMID:32756468

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation., PMID:32695104

Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss., PMID:32534028

The pharmacological management of hairy cell leukemia., PMID:32378970

Hairy Cell Leukaemia., PMID:32297104

Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia., PMID:32077130

Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia., PMID:31944549

A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains., PMID:31676342

Critical Issues in the Development of Immunotoxins for Anticancer Therapy., PMID:31669121

Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia., PMID:31628266

Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval., PMID:31594764

Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma., PMID:31500657

[Hairy cell leukemia]., PMID:31447330

Datasheet

Document Download

Research Grade Moxetumomab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Research Grade Moxetumomab [DHD38501]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only