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Research Grade Mogamulizumab

Catalog #:   DHE85301 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHE85301

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

K5-5, CCR4, C-C CKR-4, CD194, CC-CKR-4, CCR-4, C-C chemokine receptor type 4, CMKBR4

Concentration

1.93 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P51679

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG-761, KW-0761, CAS: 1159266-37-1

Clone ID

Mogamulizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Mogamulizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial, PMID: 30100375

Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma, PMID: 30981611

Mogamulizumab: An Anti-CC Chemokine Receptor 4 Antibody for T-Cell Lymphomas, PMID: 31648540

Mogamulizumab, PMID: 31643268

Mogamulizumab, PMID: 30272896

Mogamulizumab in the treatment of advanced mycosis fungoides and Sézary syndrome: safety and efficacy, PMID: 32320304

Mogamulizumab: a new tool for management of cutaneous T-cell lymphoma, PMID: 30799938

Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection, PMID: 32982179

Mogamulizumab for adult T-cell leukemia-lymphoma: a multicenter prospective observational study, PMID: 33091125

Mogamulizumab for the treatment of T-cell lymphoma, PMID: 28649848

Mogamulizumab-induced Mucocutaneous Lichenoid Reaction: A Case Report and Short Review, PMID: 32449779

Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study, PMID: 25733162

Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy, PMID: 29414279

Mogamulizumab-kpkc: A Novel Therapy for the Treatment of Cutaneous T-Cell Lymphoma, PMID: 33425472

A Phase I Study of the Anti-CC Chemokine Receptor 4 Antibody, Mogamulizumab, in Combination with Nivolumab in Patients with Advanced or Metastatic Solid Tumors, PMID: 31455681

Cutaneous T-Cell Lymphoma: Optimizing Care in Patients Receiving Anti-CCR4 Monoclonal Antibody Mogamulizumab, PMID: 31322628

Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study, PMID: 32586937

Histopathologic Characterization of Mogamulizumab-associated Rash, PMID: 32976123

Clinical efficacy of mogamulizumab for relapsed/refractory aggressive adult T-cell leukemia/lymphoma: A retrospective analysis, PMID: 32564395

Mogamulizumab Treatment Elicits Autoantibodies Attacking the Skin in Patients with Adult T-Cell Leukemia-Lymphoma, PMID: 31018922

A drug safety evaluation of mogamulizumab for the treatment of cutaneous T-Cell lymphoma, PMID: 31303060

Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma, PMID: 23110261

Mogamulizumab versus investigator's choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma, PMID: 30573506

Mogamulizumab and the treatment of CCR4-positive T-cell lymphomas, PMID: 25496334

[Development of mogamulizumab and establishment of an optimal therapy based on genomic biomarkers: from the academic viewpoint], PMID: 25948299

Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma, PMID: 28756726

A phase Ib study of utomilumab (PF-05082566) in combination with mogamulizumab in patients with advanced solid tumors, PMID: 31801624

Mogamulizumab Tops Standard of Care for CTCL, PMID: 29298770

Mogamulizumab for the treatment of cutaneous T-cell lymphoma: recent advances and clinical potential, PMID: 27247757

Mogamulizumab Plus EPOCH Therapy for Patients With Newly Diagnosed Aggressive Adult T-cell Leukemia/lymphoma, PMID: 32878812

Successful treatment of mogamulizumab-resistant mycosis fungoides with mogamulizumab plus etoposide combined therapy: Investigation of the immunomodulatory effects of etoposide on the tumor microenvironment, PMID: 32362053

Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma, PMID: 32433748

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy, PMID: 30894861

Radiation recall dermatitis induced by mogamulizumab, PMID: 31660660

Mogamulizumab versus investigator choice in relapsed/refractory adult T-cell leukemia/lymphoma: all four one or none for all?, PMID: 31040231

NCCN Guidelines Insights: Primary Cutaneous Lymphomas, Version 2.2020, PMID: 32380458

Clinical significance of chemokine receptor antagonists, PMID: 31903790

Immunohistochemistry for CCR4 C-terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T-cell leukemia/lymphoma, PMID: 33022137

Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem, PMID: 31615932

Antibodies to watch in 2019, PMID: 30516432

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study, PMID: 30452692

Adult T-Cell Leukemia/Lymphoma, PMID: 28796966

Malignancy-associated pruritus, PMID: 26416212

CCR4 and its ligands: from bench to bedside, PMID: 25087232

Quality of Life Effect of the Anti-CCR4 Monoclonal Antibody Mogamulizumab Versus Vorinostat in Patients With Cutaneous T-cell Lymphoma, PMID: 33158772

FDA Approval Summary: Mogamulizumab-kpkc for Mycosis Fungoides and Sézary Syndrome, PMID: 31366601

Effects of mogamulizumab in adult T-cell leukemia/lymphoma in clinical practice, PMID: 28152225

How I treat adult T-cell leukemia/lymphoma, PMID: 33075812

Exposure-Response Analysis for Mogamulizumab in Adults With Cutaneous T-Cell Lymphoma, PMID: 31840837

Mogamulizumab-Associated Cutaneous Granulomatous Drug Eruption Mimicking Mycosis Fungoides but Possibly Indicating Durable Clinical Response, PMID: 31141114

Classical and biological treatments in mycosis fungoides/Sézary syndrome. New horizons in oncodermatology., PMID:40521064

Novel and recurrent histopathologic patterns of mogamulizumab-associated rash: diagnostic implications and insights for accurate diagnosis., PMID:40420651

Mogamulizumab induced lymph node enlargement mimicking mycosis fungoides progression., PMID:40392975

A phase 2 Trial of CHOP with Anti-CCR4 Antibody Mogamulizumab for older Patients with Adult T-Cell Leukemia/Lymphoma., PMID:40373281

Selecting appropriate therapy for cutaneous T-cell lymphomas (CTCLs): recent advances and the unmet need., PMID:40336318

Evaluation of the anti-CCR4 monoclonal antibody Mogamulizumab in advanced cutaneous T-cell lymphomas and with large cell transformation., PMID:40192548

Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors., PMID:40180420

Therapeutic advances for Cutaneous T Cell Lymphoma., PMID:40131851

Systemic Targeted Therapies in Patients with Relapsed/Refractory Advanced Stage Cutaneous T-cell Lymphoma: A Real-world Single-centre Case Series., PMID:40079767

Effects of tucidinostat in adult T-cell leukemia/lymphoma in clinical practice., PMID:40067419

Clinical and therapeutic significance of genetic profiling in adult T-cell leukemia/lymphoma., PMID:40056531

Cutaneous T-cell lymphomas: a real-life experience of anticipated use of mogamulizumab in Italy., PMID:40042219

[Successful treatment with EPOCH followed by mogamulizumab for angioimmunoblastic T-cell lymphoma with myelofibrosis and pure red cell aplasia]., PMID:39924203

Management of mycosis fungoides and Sézary syndrome with mogamulizumab in combination with psoralen plus UVA: two case reports., PMID:39906397

Mogamulizumab-induced alopecia. Multicentric case series: Clinical, trichoscopic and histological characterization., PMID:39902943

Significant detrimental impact of pre-transplant mogamulizumab on the post-transplant outcome with a short interval between the last mogamulizumab and transplantation., PMID:39901032

Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab., PMID:39894454

The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue., PMID:39857770

Targeted antibody therapy as a treatment strategy for aggressive adult T-cell leukemia/lymphoma., PMID:39827571

Practical recommendations for therapy and monitoring of mogamulizumab patients in Germany., PMID:39723687

Successful Treatment of Mogamulizumab-Associated Rash With Upadacitinib: Evidence From 2 Cases., PMID:39661359

Mogamulizumab-Associated Autoimmune Diseases: Insights From FAERS Database Analysis., PMID:39659050

Clinical significance of NOTCH1 and FBXW7 alterations in adult T-cell leukemia/lymphoma., PMID:39586983

Potential mogamulizumab-associated inflammatory bowel disease in cutaneous T-cell lymphoma management., PMID:39583058

Improved survival among elderly patients with aggressive adult T-cell leukemia/lymphoma: Impact of mogamulizumab-containing chemotherapy., PMID:39390209

Real-world Use of Mogamulizumab Among Patients With Mycosis Fungoides and Sézary Syndrome Before and During COVID-19 in the United States., PMID:39379224

Chemotherapy and allo-HSCT for young patients with aggressive ATL., PMID:39366195

Mogamulizumab-induced bone granuloma., PMID:39332664

Mogamulizumab and Concomitant Hypofractionated Low-Dose Total Skin Electron Beam Therapy (2 × 4 Gy) in Cutaneous T-Cell Lymphoma: Proof of Principle, Report of Two Cases., PMID:39330028

Health-related quality of life in cutaneous T-cell lymphoma: A post hoc analysis of a phase 3 trial in mycosis fungoides and Sézary syndrome., PMID:39315857

A Retrospective Cohort Study to Determine Real-World Treatment Patterns in Patients with Sézary Syndrome in the United States., PMID:39305456

Systemic treatments with monoclonal antibodies in mycosis fungoides and Sézary syndrome., PMID:39295883

[Mogamulizumab-associated rash: cutaneous T-cell lymphoma in complete remission]., PMID:39278871

Atypical Presentation of Invasive Aspergillosis during Treatment with Mogamulizumab., PMID:39194909

Mogamulizumab for Sézary syndrome: long-term remission with associated autoimmune haemolytic anaemia., PMID:39193694

[Persistent Effects of Mogamulizumab on Peripheral Blood Lesions after Treatment Completion in a Patient with Refractory Sézary Syndrome-A Case Report]., PMID:39191715

A case report of refractory advanced-stage mycosis fungoides: successful treatment and improved patient quality of life with mogamulizumab., PMID:39091322

Real-life efficacy of immunotherapy for Sézary syndrome: a multicenter observational cohort study., PMID:39007062

Immune-related adverse events associated with mogamulizumab: a comprehensive review of the literature., PMID:38990648

Mogamulizumab-associated rash - Case series and review of the literature., PMID:38924340

Safety and effectiveness of mogamulizumab in relapsed or refractory CC chemokine receptor 4-positive peripheral T-cell lymphoma and relapsed or refractory cutaneous T-cell lymphoma: A post-marketing surveillance in Japan., PMID:38847317

Mogamulizumab associated crusted scabies: a rare diagnostic confounder., PMID:38842065

Advances in the pharmacological management of cutaneous T-cell lymphoma., PMID:38828644

Flow cytometric profiles with CD7 and CADM1 in CD4+ T cells are promising indicators for prognosis of aggressive ATL., PMID:38820467

A Narrative Review of the State of the Art of CCR4-Based Therapies in Cutaneous T-Cell Lymphomas: Focus on Mogamulizumab and Future Treatments., PMID:38804300

Effectiveness and safety of mogamulizumab for the treatment of Sézary syndrome in very elderly patients: A real-world, multicentre, retrospective study conducted in France., PMID:38804019

[Side effects of dermato-oncologic therapies]., PMID:38802653

[Drug-related exanthema under immunotherapy and targeted oncological therapy]., PMID:38772932

Fulminant hepatitis in a hepatitis B surface antigen-positive patient with adult T-cell leukemia-lymphoma after mogamulizumab monotherapy., PMID:38770705

Urticarial mycosis fungoides: A distinctive presentation with blood involvement and a peculiar immunophenotype., PMID:38769716

Datasheet

Document Download

Research Grade Mogamulizumab.pdf

 

$ 372
Product specifications
100 μg 372 1 mg 1486

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Research Grade Mogamulizumab [DHE85301]
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