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Research Grade Ibalizumab

Catalog #:   DHB95901 Specific References (99) DATASHEET
Host species: Humanized
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB95901

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4

Concentration

1.91 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01730

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Hu5A8, TMB-355, TNX-355, CAS: 680188-33-4

Clone ID

Ibalizumab

Data Image
  • Bioactivity
    Detects Human CD4 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Ibalizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Ibalizumab, PMID: 29746266

Ibalizumab: A Review in Multidrug-Resistant HIV-1 Infection, PMID: 31970712

Ibalizumab, a Novel Monoclonal Antibody for the Management of Multidrug-Resistant HIV-1 Infection, PMID: 30885900

Ibalizumab: First Global Approval, PMID: 29675744

Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1, PMID: 30110589

Ibalizumab, PMID: 31643628

Ibalizumab: The First Monoclonal Antibody for the Treatment of HIV-1 Infection, PMID: 32659101

Ibalizumab, PMID: 30000027

Ibalizumab and Fostemsavir in the Management of Heavily Pre-Treated HIV-infected Patients, PMID: 30378502

Ibalizumab for the treatment of multidrug-resistant HIV-1 infection, PMID: 30740610

Ibalizumab-uiyk (Trogarzo) for multidrug-resistant HIV, PMID: 29667947

Ibalizumab Targeting CD4 Receptors, An Emerging Molecule in HIV Therapy, PMID: 29230203

Ibalizumab in Multidrug-Resistant HIV - Accepting Uncertainty, PMID: 30110580

Cancer immunotherapy via targeted TGF-β signalling blockade in T H cells, PMID: 33087933

Bictegravir/emtricitabine/tenofovir alafenamide, Ibalizumab, and Ozenoxacin, PMID: 29954693

Clinical and Economic Impact of Ibalizumab for People With Multidrug-Resistant HIV in the United States, PMID: 31929403

Ibalizumab, a CD4-specific mAb to inhibit HIV-1 infection, PMID: 17668367

Correction to: Ibalizumab: First Global Approval, PMID: 29846911

Antibodies to watch in 2019, PMID: 30516432

Ibalizumab-human CD4 receptor interaction: computational alanine scanning molecular dynamics studies, PMID: 25756667

Efficacy, Pharmacokinetics, and Safety Over 48 Weeks With Ibalizumab-Based Therapy in Treatment-Experienced Adults Infected With HIV-1: A Phase 2a Study, PMID: 33427765

Insight into the modified Ibalizumab-human CD4 receptor interactions: using a computational binding free energy approach, PMID: 25342515

Epitope mapping of ibalizumab, a humanized anti-CD4 monoclonal antibody with anti-HIV-1 activity in infected patients, PMID: 20463063

Cerebrospinal fluid viral replication and burden of resistance in three HIV-1-infected people taking Ibalizumab with multiple drug class-wide resistance, PMID: 33105172

Anti-CD4 monoclonal antibody ibalizumab exhibits breadth and potency against HIV-1, with natural resistance mediated by the loss of a V5 glycan in envelope, PMID: 23023102

Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab, PMID: 21289125

Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection, PMID: 20639524

Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults, PMID: 19015347

Antibody-based strategies in HIV therapy, PMID: 33045349

Ibalizumab-uiyk as a bridge therapy for a patient with drug-resistant HIV-1 infection receiving chemotherapy: A case report, PMID: 34111306

The Cost-Effectiveness and Budget Impact of Ibalizumab-uiyk for Adults with Multidrug-Resistant HIV-1 Infection in the United States, PMID: 33532919

Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity, PMID: 24097413

Distinct HIV-1 Neutralization Potency Profiles of Ibalizumab-Based Bispecific Antibodies, PMID: 27792681

Anti-HIV-1 Antibodies: An Update, PMID: 32152957

Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody, PMID: 21134642

Pharmaceutical Approval Update, PMID: 29896030

Next-generation oral preexposure prophylaxis: beyond tenofovir, PMID: 23032733

Choosing appropriate pharmacotherapy for drug-resistant HIV, PMID: 30676115

The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment, PMID: 22001594

HIV-1 entry inhibitors: recent development and clinical use, PMID: 23290628

New Drugs 2019, part 2, PMID: 31022027

Generative models of conformational dynamics, PMID: 24446358

Recent advances in antiretroviral drugs, PMID: 20698725

HIV-1 entry inhibitors: an overview, PMID: 19339945

Antibodies to watch in 2018, PMID: 29300693

New drug for multidrug-resistant HIV, PMID: 29621221

Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans, PMID: 33073698

An option for treatment of multidrug-resistant HIV, PMID: 30194407

Current Status of the Pharmacokinetics and Pharmacodynamics of HIV-1 Entry Inhibitors and HIV Therapy, PMID: 28738768

Monoclonal Antibodies Against Infectious Microbes: So Long and Too Little!, PMID: 32164518

Ibalizumab plus an optimized background regimen in treatment-experienced patients infected with multidrug resistant HIV-1: A phase 3, multicenter, expanded access study., PMID:40465394

FlowDesign: Improved design of antibody CDRs through flow matching and better prior distributions., PMID:40306278

Investigating the combination of Temsavir and entry inhibitors on HIV replication: Synergistic and antagonistic effects observed against various R5-tropic envelopes., PMID:39642611

PRESTIGIO RING: "A 28-year-old highly treatmentexperienced man with vertical HIV infection on ibalizumab therapy: ART simplification perspectives"., PMID:39560045

Emerging integrase resistance in an international perinatal virtual clinic., PMID:39469738

Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV., PMID:39417932

Efficacy and Safety of 2 Fixed Doses of Ibalizumab Plus Optimized Background Regimen in Treatment-Experienced HIV-Positive Individuals., PMID:39250331

US cost-utility model of lenacapavir plus optimized background regimen (OBR) vs fostemsavir plus OBR and ibalizumab plus OBR for people with HIV with multidrug resistance., PMID:39213144

A Narrative Review of Novel Agents for Managing Heavily Treatment-Experienced People Living With HIV., PMID:39157636

Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration., PMID:39138183

Strategic use of salvage long-acting antiretrovirals in the setting of resistance., PMID:39045845

Consensus recommendations for use of long-acting antiretroviral medications in the treatment and prevention of HIV-1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy, Canadian HIV and Viral Hepatitis Pharmacists Network, European AIDS Clinical Society, and Society of Infectious Diseases Pharmacists: An executive summary., PMID:39005161

Consensus recommendations for use of long-acting antiretroviral medications in the treatment and prevention of HIV-1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy, Canadian HIV and Viral Hepatitis Pharmacists Network, European AIDS Clinical Society, and Society of Infectious Diseases Pharmacists., PMID:39005160

Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab., PMID:38971430

Consensus recommendations for the use of novel antiretrovirals in persons with HIV who are heavily treatment-experienced and/or have multidrug-resistant HIV-1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy: An executive summary., PMID:38853605

Consensus recommendations for the use of novel antiretrovirals in persons with HIV who are heavily treatment-experienced and/or have multidrug-resistant HIV-1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy., PMID:38853601

Ex vivo sensitivity to broadly neutralizing antibodies and anti-CD4 antibody UB-421 of infectious viral isolates from people living with multidrug-resistant HIV., PMID:38728839

Salvage Therapy Including Foscarnet and Ibalizumab for Multidrug-Resistant Human Immunodeficiency Virus Type 2 Infection., PMID:38630945

Cross-resistance to entry inhibitors and lenacapavir resistance through Week 52 in study CAPELLA., PMID:38085652

Identification of potential therapeutic drugs targeting core genes for systemic lupus erythematosus (SLE) and coexisting COVID-19: Insights from bioinformatic analyses., PMID:38018597

Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review., PMID:37561283

Efficacy and Safety of Two-Drug Regimens That Are Approved from 2018 to 2022 for the Treatment of Human Immunodeficiency Virus (HIV) Disease and Its Opportunistic Infections., PMID:37374953

Lenacapavir (Sunlenca) for multidrug-resistant HIV., PMID:37155250

Indirect Treatment Comparisons of Lenacapavir Plus Optimized Background Regimen Versus Other Treatments for Multidrug-Resistant Human Immunodeficiency Virus., PMID:36566886

Realizing the promise of long-acting antiretroviral treatment strategies for individuals with HIV and adherence challenges: an illustrative case series., PMID:36435793

HIV-1 bispecific antibody iMab-N6 exhibits enhanced breadth but not potency over its parental antibodies iMab and N6., PMID:36071449

Quantitative PET imaging of the CD4 pool in nonhuman primates., PMID:36028577

Design of a Bispecific HIV Entry Inhibitor Targeting the Cell Receptor CD4 and Viral Fusion Protein Gp41., PMID:35711654

Comparative Efficacy and Safety of Fostemsavir in Heavily Treatment-Experienced People With HIV-1., PMID:35610081

Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics., PMID:35550505

Ibalizumab shows in-vitro activity against group A and group B HIV-2 clinical isolates., PMID:35262531

Achieving virological control in pan-resistant HIV-1 infection: A case series., PMID:35255457

Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment., PMID:34896364

Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc., PMID:34628442

Reactivation of Hepatitis B After Ibalizumab Therapy for Multidrug-Resistant Human Immunodeficiency Virus., PMID:34549064

Hepatotoxicity of contemporary antiretroviral drugs., PMID:34545037

Broad and potent bispecific neutralizing antibody gene delivery using adeno-associated viral vectors for passive immunization against HIV-1., PMID:34509584

Ibalizumab-uiyk as a bridge therapy for a patient with drug-resistant HIV-1 infection receiving chemotherapy: A case report., PMID:34111306

The Cost-Effectiveness and Budget Impact of Ibalizumab-uiyk for Adults with Multidrug-Resistant HIV-1 Infection in the United States., PMID:33532919

Efficacy, Pharmacokinetics, and Safety Over 48 Weeks With Ibalizumab-Based Therapy in Treatment-Experienced Adults Infected With HIV-1: A Phase 2a Study., PMID:33427765

Cerebrospinal fluid viral replication and burden of resistance in three HIV-1-infected people taking Ibalizumab with multiple drug class-wide resistance., PMID:33105172

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells., PMID:33087933

Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans., PMID:33073698

Antibody-based strategies in HIV therapy., PMID:33045349

Ibalizumab: The First Monoclonal Antibody for the Treatment of HIV-1 Infection., PMID:32659101

Monoclonal Antibodies Against Infectious Microbes: So Long and Too Little!, PMID:32164518

Anti-HIV-1 Antibodies: An Update., PMID:32152957

Ibalizumab: A Review in Multidrug-Resistant HIV-1 Infection., PMID:31970712

Clinical and Economic Impact of Ibalizumab for People With Multidrug-Resistant HIV in the United States., PMID:31929403

Datasheet

Document Download

Research Grade Ibalizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Ibalizumab [DHB95901]
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