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Research Grade Fremanezumab

Catalog #:   DHC22402 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG2-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC22402

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

CCP, PDN-21, CALCA, Calcitonin carboxyl-terminal peptide, Calcitonin, CALC1, Calcitonin gene-related peptide II, CALCB, Calcitonin gene-related peptide 2, Beta-CGRP, CALC2, CGRP-II, Beta-type CGRP

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01258 & P10092

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

LBR-101, PF-04427429, RI-307, RN-307, TEV-48125, fremanezumab-vfrm, CAS: 1655501-53-3

Clone ID

Fremanezumab

Data Image
  • SDS-PAGE
    SDS PAGE for Fremanezumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Fremanezumab for the Preventive Treatment of Chronic Migraine, PMID: 29171818

Fremanezumab: a disease-specific option for the preventive treatment of migraine, including difficult-to-treat migraine, PMID: 32832978

Fremanezumab for migraine, PMID: 32346217

Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial, PMID: 29800211

Fremanezumab for the prevention of chronic and episodic migraine, PMID: 31050694

Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial, PMID: 31427046

Fremanezumab for the preventive treatment of migraine, PMID: 31177856

Long-term safety, tolerability, and efficacy of fremanezumab in migraine: A randomized study, PMID: 32913018

From LBR-101 to Fremanezumab for Migraine, PMID: 30311143

Fremanezumab as a preventive treatment for episodic and chronic migraine, PMID: 31043094

Fremanezumab, PMID: 31644089

An Evidence-Based Review of Fremanezumab for the Treatment of Migraine, PMID: 32222952

Fremanezumab for the preventive treatment of migraine in adults, PMID: 31220963

Early Onset of Efficacy With Fremanezumab for the Preventive Treatment of Chronic Migraine, PMID: 31675102

The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study, PMID: 32958075

Fremanezumab (Ajovy) and galcanezumab (Emgality) for migraine prevention, PMID: 30681655

Fremanezumab, PMID: 30371997

No "Wearing-Off Effect" Seen in Quarterly or Monthly Dosing of Fremanezumab: Subanalysis of a Randomized Long-Term Study, PMID: 33009665

Migraine overview and summary of current and emerging treatment options, PMID: 30681821

Fremanezumab: First Global Approval, PMID: 30406901

Treatment benefit among migraine patients taking fremanezumab: results from a post hoc responder analysis of two placebo-controlled trials, PMID: 33413075

Safety profile of erenumab, galcanezumab and fremanezumab in pregnancy and lactation: Analysis of the WHO pharmacovigilance database, PMID: 33435709

Effect of fremanezumab on quality of life and productivity in patients with chronic migraine, PMID: 32747522

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days, PMID: 30120138

A comprehensive overview and safety evaluation of fremanezumab as a preventive therapy for migraine, PMID: 32116061

Fremanezumab for migraine prevention: more effective, less costly, PMID: 32501385

Monthly versus quarterly fremanezumab for the prevention of migraine: a systemic review and meta-analysis from randomized controlled trials, PMID: 33136176

Fremanezumab in the treatment of migraines: evidence to date, PMID: 31686900

Safety and Efficacy of Fremanezumab for the Prevention of Migraine: A Meta-Analysis From Randomized Controlled Trials, PMID: 32508742

Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses, PMID: 32445498

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries, PMID: 30109438

Do Treatment Strategies of Fremanezumab Have Similar Effect on Migraine?, PMID: 32011737

Fremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery - Potential role in conditions of severe vasoconstriction, PMID: 31589869

Monoclonal antibodies for the prevention of migraine, PMID: 31550937

Improvements across a range of patient-reported domains with fremanezumab treatment: results from a patient survey study, PMID: 32887548

Effects of fremanezumab on the use of acute headache medication and associated symptoms of migraine in patients with episodic migraine, PMID: 31752521

CGRP as the target of new migraine therapies - successful translation from bench to clinic, PMID: 29691490

CGRP Antibodies as Prophylaxis in Migraine, PMID: 30550780

Correction to: Fremanezumab: First Global Approval, PMID: 30859411

Safety and Tolerability of Fremanezumab for the Prevention of Migraine: A Pooled Analysis of Phases 2b and 3 Clinical Trials, PMID: 30977520

What's New in the Treatment of Migraine?, PMID: 31393282

Drugs for Migraine, PMID: 33434187

Population pharmacokinetic modelling and simulation of fremanezumab in healthy subjects and patients with migraine, PMID: 31418911

Current and emerging evidence-based treatment options in chronic migraine: a narrative review, PMID: 31470791

Role of CGRP in Migraine, PMID: 30725283

Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier, PMID: 31895266

Fremanezumab as Add-On Treatment for Patients Treated With Other Migraine Preventive Medicines, PMID: 28862758

Cost of fremanezumab, erenumab, galcanezumab and onabotulinumtoxinA associated adverse events, for migraine prophylaxis in Spain, PMID: 32484365

Antibodies to watch in 2019, PMID: 30516432

Baloxavir marboxil, Fremanezumab-vfrm, Galcanezumab-gnlm, and Lofexidine hydrochloride, PMID: 30580925

Retrospective cohort study of anti-CGRP monoclonal antibody unresponsive migraine individuals treated with atogepant: The RESCUE study., PMID:40501126

A real-world study of the efficacy and tolerability of fremanezumab in migraine patients with a median follow-up of 14 months., PMID:40462186

Management of local and delayed cutaneous hypersensitivity reactions to anti-CGRP antibodies: implications for continuing treatment., PMID:40456979

Repurposed versus disease-specific medicinals for the prophylaxis of migraine: an updated systematic review., PMID:40447296

Postmarketing safety of migraine prophylactic monoclonal antibodies: An EudraVigilance database analysis of eptinezumab, fremanezumab, galcanezumab, and erenumab., PMID:40439253

Cortical Thickness Changes in Migraine Patients Treated with Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies: A Prospective Age- and Sex-Matched Controlled Study., PMID:40426977

The Effect of Fremanezumab on Pain in Patients with Complex Regional Pain Syndrome: Study Protocol of a Randomized, Double-Blind, Proof-of-Concept, Placebo-Controlled Trial., PMID:40426639

Calcitonin gene-related peptide-targeted therapies for migraine., PMID:40343132

Efficacy of monoclonal antibodies against CGRP in migraine patients with fibromyalgia comorbidity: a retrospective monocentric observational study., PMID:40329175

Fremanezumab for the Treatment of Patients With Migraine and Comorbid Major Depressive Disorder: The UNITE Randomized Clinical Trial., PMID:40323613

Increased infection risk in patients on preventive CGRP-targeting therapies- a meta-analysis and clinical effect assessment., PMID:40281424

Efficacy of anti-calcitonin gene-related peptide monoclonal antibodies in hemiplegic migraine: a case report and review of literature., PMID:40264646

Identifying signals of disproportionate reporting for calcitonin gene-related peptide inhibitors: real-world evidence from the FDA adverse event reporting system., PMID:40261259

Migraine treatment with CGRP monoclonal antibodies: patient evaluation of a mandatory treatment holiday in Belgium., PMID:40210844

Predictors of Response to Treatment With Anti-calcitonin Gene-Related Peptide (CGRP) Antibodies in Real-World Patients With Episodic Migraine: A Two- and Four-Month Prospective Study., PMID:40206906

Dual biological treatments in immune-mediated disorders: a single center experience., PMID:40200173

A National Cross-Sectional Survey on Real-World Experiences of Calcitonin Gene-Related Peptide (CGRP) Monoclonal Antibody Use in Adults with Migraine in Finland., PMID:40189729

Health care resource utilization and direct costs incurred over 12 months by patients with migraine initiating self-injectable calcitonin gene-related peptide monoclonal antibodies: A US real-world study., PMID:40152794

Patient satisfaction with calcitonin gene-related peptide monoclonal antibodies in migraine: A multicenter prospective cohort study., PMID:40135519

Fremanezumab for the Treatment of Migraine Complicated by Medication Overuse: A Systematic Review., PMID:40121372

CROATIAN GUIDELINES FOR SPECIFIC PREVENTIVE TREATMENT OF MIGRAINE WITH MONOCLONAL ANTIBODIES TARGETING CALCITONIN GENE-RELATED PEPTIDE (CGRP) (EPTINEZUMAB, FREMANEZUMAB, AND GALCANEZUMAB) OR THE CGRP RECEPTOR (ERENUMAB)., PMID:40104234

Efficacy and continuability of 675 mg fremanezumab administration over 2 years., PMID:40069630

Treatment Patterns and Healthcare Resource Utilization by Gender and Migraine Frequency in Adult Patients Receiving Galcanezumab Versus Standard of Care Preventive Medications Over 24 months: A United States Retrospective Claims Study., PMID:40046564

Real-World Lessons with Fremanezumab as the Third Available CGRP Monoclonal Antibody in a Third-Level Hospital: Focus on the Factors Predicting Response., PMID:40004586

Review: An Update on CGRP Monoclonal Antibodies for the Preventive Treatment of Episodic Migraine., PMID:39998706

Health Technology Assessment: Evaluation of 8 CGRP-Targeted Therapy Drugs for the Treatment of Migraine., PMID:39991088

The anti-CGRP mAb Fremanezumab reverts the anti-inflammatory effects of CGRP in vitro but does not alter disease evolution in a mouse model of progressive multiple sclerosis., PMID:39988092

The effect of calcitonin gene-related peptide monoclonal antibodies on restless legs syndrome in patients with migraine., PMID:39972460

Physical activity as a predictor of fremanezumab response in chronic migraine - the Phy-Fre-Mig study., PMID:39953381

Prevention of Episodic Migraine Headache Using Pharmacologic Treatments in Outpatient Settings: A Clinical Guideline From the American College of Physicians., PMID:39899861

Switching between anti-CGRP monoclonal antibodies in migraine prophylaxis., PMID:39884968

Pharmacological differences and switching among anti-CGRP monoclonal antibodies: A narrative review., PMID:39825578

Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication., PMID:39816898

US Real-World Effectiveness, Tolerability, and Healthcare Resource Utilization After Addition of Fremanezumab for Preventive Treatment in Patients Using Gepants for Acute Treatment of Migraine: Results From a Retrospective Chart Review., PMID:39775579

Could CGRP mAbs for migraine trigger rheumatoid arthritis? Insights from a case report., PMID:39754737

Comparison of Early-onset Efficacy of Anti-calcitonin Gene-related Peptide Monoclonal Antibodies for Patients with Migraine in Real-world Clinical Practice: Study Protocol for an Exploratory Clinical Trial., PMID:39662907

One-step ultra-rapid immunoassay of calcitonin gene-related peptide for migraine diagnosis., PMID:39608279

Switching from ligand to receptor anti-calcitonin gene-related peptide (CGRP) antibodies or vice versa in non-responders: A controlled cohort study., PMID:39607215

Benefit-risk assessment based on number needed to treat and number needed to harm: Atogepant vs. calcitonin gene-related peptide monoclonal antibodies., PMID:39558612

Crowdsourcing Adverse Events Associated With Monoclonal Antibodies Targeting Calcitonin Gene-Related Peptide Signaling for Migraine Prevention: Natural Language Processing Analysis of Social Media., PMID:39515814

Efficacy of eptinezumab in non-responders to subcutaneous monoclonal antibodies against CGRP and the CGRP receptor: A retrospective cohort study., PMID:39469839

Onabotulinumtoxin A for the Treatment of Post-Traumatic Headache: Is It Better than Anti-CGRP Antibodies?, PMID:39453203

Hypersensitivity to the CGRP Inhibitor Monoclonal Antibodies Galcanezumab, Erenumab, and Fremanezumab With Tolerance to Eptinezumab., PMID:39441051

Efficacy and Tolerability of Anti-CGRP Monoclonal Antibodies in Patients Aged ≥ 65 Years With Daily or Nondaily Migraine., PMID:39399553

Comparative efficacy and safety of different pharmacological therapies to medication overuse headache: a network meta-analysis., PMID:39375607

Preventive drug treatments for adults with chronic migraine: a systematic review with economic modelling., PMID:39365169

Calcitonin Gene-Related Peptide Monoclonal Antibodies: Key Lessons from Real-World Evidence., PMID:39335442

Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA., PMID:39335375

The influence of pharmacodynamics and pharmacokinetics on the antimigraine efficacy and safety of novel anti-CGRPergic pharmacotherapies: a narrative review., PMID:39319681

Case series on monoclonal antibodies targeting calcitonin gene-related peptide in migraine patients during pregnancy: Enhancing safety data., PMID:39314064

Datasheet

Document Download

Research Grade Fremanezumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Fremanezumab [DHC22402]
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