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Research Grade Erenumab

Catalog #:   DHH31001 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG2-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHH31001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2-lambda

Clonality

Monoclonal

Target

CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q16602

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG 334, erenumab-aooe, CAS: 1582205-90-0

Clone ID

Erenumab

Data Image
  • SDS-PAGE
    SDS PAGE for Erenumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

A Controlled Trial of Erenumab for Episodic Migraine, PMID: 29171821

Erenumab in the treatment of migraine, PMID: 30235976

Erenumab-aooe, PMID: 30559520

ARISE: A Phase 3 randomized trial of erenumab for episodic migraine, PMID: 29471679

The role of erenumab in the treatment of migraine, PMID: 32523630

Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial, PMID: 28460892

Erenumab for episodic migraine prophylaxis, PMID: 30614741

Vascular safety of erenumab for migraine prevention, PMID: 31852816

Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study, PMID: 30996060

Erenumab for migraine, PMID: 30670893

Erenumab: A First-in-Class Monoclonal Antibody for Migraine Prevention, PMID: 30813769

Erenumab safety and efficacy in migraine: A systematic review and meta-analysis of randomized clinical trials, PMID: 31876735

Erenumab: First Global Approval, PMID: 29968151

Early onset of efficacy with erenumab in patients with episodic and chronic migraine, PMID: 30276500

Real-World Patient Experience With Erenumab for the Preventive Treatment of Migraine, PMID: 32920850

Erenumab in chronic migraine with medication overuse: Subgroup analysis of a randomized trial, PMID: 30996056

Efficacy and safety of erenumab in women with a history of menstrual migraine, PMID: 32746775

Erenumab, PMID: 31643409

Nonclinical safety evaluation of erenumab, a CGRP receptor inhibitor for the prevention of migraine, PMID: 31085251

One-year sustained efficacy of erenumab in episodic migraine: Results of the STRIVE study, PMID: 32636324

Central effects of erenumab in migraine patients: An event-related functional imaging study, PMID: 32917805

Real-world effectiveness and tolerability of erenumab: A retrospective cohort study, PMID: 32791922

Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study, PMID: 30360965

Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination, PMID: 31159727

A Randomized Phase 2 Study of Erenumab for the Prevention of Episodic Migraine in Japanese Adults, PMID: 31612482

Erenumab, PMID: 30000991

Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience, PMID: 32517693

Erenumab for Preventive Treatment of Migraine: A Systematic Review and Meta-Analysis of Efficacy and Safety, PMID: 30793254

In brief: Erenumab (Aimovig) hypersensitivity, PMID: 31022159

A prospective real-world analysis of erenumab in refractory chronic migraine, PMID: 32487102

Long-term safety and efficacy of erenumab in patients with chronic migraine: Results from a 52-week, open-label extension study, PMID: 32216456

Erenumab in Chronic Migraine: An Australian Experience, PMID: 32990364

Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study, PMID: 32493206

Migraine overview and summary of current and emerging treatment options, PMID: 30681821

Erenumab Side Effects, PMID: 31297805

Long-term efficacy and safety of erenumab in migraine prevention: Results from a 5-year, open-label treatment phase of a randomized clinical trial, PMID: 33400330

Erenumab-Induced Severe Nausea Leading to Smoking Cessation: A Retrospective Case Series, PMID: 33202039

Erenumab does not alter cerebral hemodynamics and endothelial function in migraine without aura, PMID: 32867533

Hypertension: A new safety risk for patients treated with erenumab, PMID: 33423274

Efficacy and safety of erenumab (AMG334) in chronic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study, PMID: 29984601

Erenumab During Breastfeeding, PMID: 31381367

Erenumab is effective in reducing migraine frequency and improving physical functioning, PMID: 30108057

Long-term safety and tolerability of erenumab: Three-plus year results from a five-year open-label extension study in episodic migraine, PMID: 31146544

Predicting erenumab adverse events with single-cell genomics, PMID: 32653068

Safety profile of erenumab, galcanezumab and fremanezumab in pregnancy and lactation: Analysis of the WHO pharmacovigilance database, PMID: 33435709

Pharmacoeconomic Review Report: Erenumab (Aimovig): (Novartis Pharmaceuticals Canada Inc.) [Internet], PMID: 33476110

Erenumab Efficacy on Comorbid Cluster Headache in Patients With Migraine: A Real-World Case Series, PMID: 32359106

Erenumab-aooe, Benralizumab, and Tezacaftor/ivacaftor, PMID: 30190109

Erenumab in Chronic Migraine Patients Who Previously Failed Five First-Line Oral Prophylactics and OnabotulinumtoxinA: A Dual-Center Retrospective Observational Study, PMID: 32547474

Clinical Review Report: Erenumab (Aimovig): (Novartis Pharmaceuticals Canada Inc.) [Internet], PMID: 33471453

Erenumab for Chronic Cluster Headache: A Randomized Clinical Trial., PMID:40526384

Retrospective cohort study of anti-CGRP monoclonal antibody unresponsive migraine individuals treated with atogepant: The RESCUE study., PMID:40501126

Treatment of Persistent Headache After Normalization of CSF Pressure., PMID:40459314

Management of local and delayed cutaneous hypersensitivity reactions to anti-CGRP antibodies: implications for continuing treatment., PMID:40456979

Repurposed versus disease-specific medicinals for the prophylaxis of migraine: an updated systematic review., PMID:40447296

Postmarketing safety of migraine prophylactic monoclonal antibodies: An EudraVigilance database analysis of eptinezumab, fremanezumab, galcanezumab, and erenumab., PMID:40439253

Short-Term Immunosuppression in Rats Induces Prolonged Immune Tolerance Towards a Human Monoclonal Antibody, Erenumab., PMID:40379907

Calcitonin gene-related peptide-targeted therapies for migraine., PMID:40343132

Safety, efficacy, and compliance of moderate-to-high dose eptinezumab and erenumab in chronic migraine patients with medication-overuse headache: an updated systematic review and meta-analysis., PMID:40329188

Efficacy of monoclonal antibodies against CGRP in migraine patients with fibromyalgia comorbidity: a retrospective monocentric observational study., PMID:40329175

Swiss Quality of Life and Health Care Impact Assessment in a Real-World Erenumab-Treated Migraine Population: Results over 2 years., PMID:40304557

Increased infection risk in patients on preventive CGRP-targeting therapies- a meta-analysis and clinical effect assessment., PMID:40281424

Plasma SuPAR and therapeutic response to erenumab in migraine: a REFORM study., PMID:40275185

Clinical predictors for efficacy of erenumab for migraine: a Registry for Migraine (REFORM) study., PMID:40270925

Migraine treatment with CGRP monoclonal antibodies: patient evaluation of a mandatory treatment holiday in Belgium., PMID:40210844

[Successful Management of Wearing-off effect with Eptinezumab: Lessons from a case with Chronic Migraine Refractory to Two Subcutaneous CGRP Antibodies]., PMID:40191903

A National Cross-Sectional Survey on Real-World Experiences of Calcitonin Gene-Related Peptide (CGRP) Monoclonal Antibody Use in Adults with Migraine in Finland., PMID:40189729

Efficacy and safety of mAbs anti-CGRP/CGRP R (eptinezumab and erenumab) or atogepant in combination with onabotulinumtoxinA in refractory chronic migraine: a clinical trial protocol., PMID:40169386

Quickest way to less headache days: an operational research model and its implementation for chronic migraine., PMID:40165130

Health care resource utilization and direct costs incurred over 12 months by patients with migraine initiating self-injectable calcitonin gene-related peptide monoclonal antibodies: A US real-world study., PMID:40152794

Tracking Migraine Symptoms: A Longitudinal Comparison of Smartphone-Based Headache Diaries and Clinical Interviews., PMID:40137454

Patient satisfaction with calcitonin gene-related peptide monoclonal antibodies in migraine: A multicenter prospective cohort study., PMID:40135519

Unveiling the efficacy and safety of Erenumab, a monoclonal antibody targeting calcitonin gene-related peptide (CGRP) receptor, in patients with chronic and episodic migraine: a GRADE-assessed systematic review and meta-analysis of randomized clinical trials with subgroup analysis., PMID:40134001

CROATIAN GUIDELINES FOR SPECIFIC PREVENTIVE TREATMENT OF MIGRAINE WITH MONOCLONAL ANTIBODIES TARGETING CALCITONIN GENE-RELATED PEPTIDE (CGRP) (EPTINEZUMAB, FREMANEZUMAB, AND GALCANEZUMAB) OR THE CGRP RECEPTOR (ERENUMAB)., PMID:40104234

Ubrogepant, erenumab, and eptinezumab antagonize positive inotropic effects of the calcitonin gene-related peptide in the isolated human atrium., PMID:40085216

Assessing blood pressure changes and hypertension-related outcomes in patients with migraine treated with erenumab: A systematic review and meta-analysis., PMID:40084674

Efficacy and continuability of 675 mg fremanezumab administration over 2 years., PMID:40069630

Treatment Patterns and Healthcare Resource Utilization by Gender and Migraine Frequency in Adult Patients Receiving Galcanezumab Versus Standard of Care Preventive Medications Over 24 months: A United States Retrospective Claims Study., PMID:40046564

Effect of erenumab versus other migraine preventive medications on cardiovascular and cerebrovascular outcomes: A United States claims database-based observational cohort study., PMID:40033803

Real-world adherence to erenumab, rescue medication utilization, and work absenteeism for patients with migraine: Results from an outcomes-based agreement., PMID:40021466

Real-World Lessons with Fremanezumab as the Third Available CGRP Monoclonal Antibody in a Third-Level Hospital: Focus on the Factors Predicting Response., PMID:40004586

Review: An Update on CGRP Monoclonal Antibodies for the Preventive Treatment of Episodic Migraine., PMID:39998706

Health Technology Assessment: Evaluation of 8 CGRP-Targeted Therapy Drugs for the Treatment of Migraine., PMID:39991088

The effect of calcitonin gene-related peptide monoclonal antibodies on restless legs syndrome in patients with migraine., PMID:39972460

Popliteal Artery Rupture: A Rare but Life-Threatening Complication of Total Knee Arthroplasty., PMID:39935650

Improvement of Prurigo Nodularis With Erenumab., PMID:39908053

Signs of Cortical Inflammation in Migraine Measured with Quantitative Magnetic Resonance Imaging: A Registry for Migraine (REFORM) Study., PMID:39902552

Prevention of Episodic Migraine Headache Using Pharmacologic Treatments in Outpatient Settings: A Clinical Guideline From the American College of Physicians., PMID:39899861

Paralytic Ileus Following Long-term Erenumab Treatment., PMID:39894489

Switching between anti-CGRP monoclonal antibodies in migraine prophylaxis., PMID:39884968

Erenumab in a patient with persistent headaches after subarachnoid hemorrhage: A case report of an effective treatment., PMID:39865710

Cost-Utility Analysis of Erenumab Compared to Topiramate for Preventive Therapy of Migraine in Iran., PMID:39830656

Pharmacological differences and switching among anti-CGRP monoclonal antibodies: A narrative review., PMID:39825578

Efficacy and Safety of Switching Between Anti-CGRP Monoclonal Antibodies: A Detailed Monthly and Long-term Follow-up Study and Literature Review., PMID:39756881

Comparison of Early-onset Efficacy of Anti-calcitonin Gene-related Peptide Monoclonal Antibodies for Patients with Migraine in Real-world Clinical Practice: Study Protocol for an Exploratory Clinical Trial., PMID:39662907

Switching from ligand to receptor anti-calcitonin gene-related peptide (CGRP) antibodies or vice versa in non-responders: A controlled cohort study., PMID:39607215

Benefit-risk assessment based on number needed to treat and number needed to harm: Atogepant vs. calcitonin gene-related peptide monoclonal antibodies., PMID:39558612

Worldwide availability of medications for migraine and tension-type headache: A survey of the International Headache Society., PMID:39552307

Crowdsourcing Adverse Events Associated With Monoclonal Antibodies Targeting Calcitonin Gene-Related Peptide Signaling for Migraine Prevention: Natural Language Processing Analysis of Social Media., PMID:39515814

Efficacy of eptinezumab in non-responders to subcutaneous monoclonal antibodies against CGRP and the CGRP receptor: A retrospective cohort study., PMID:39469839

Datasheet

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Research Grade Erenumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Erenumab [DHH31001]
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