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Research Grade Caplacizumab

Catalog #:   DHC08501 Specific References (99) DATASHEET
Host species: Humanized
Isotype: VH-VH
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC08501

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

VH-VH

Clonality

Monoclonal

Target

von Willebrand antigen II, von Willebrand factor, F8VWF, vWF, VWF

Concentration

1.6 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P04275

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

20mM citric acid, 6.2% sucrose, 0.01% Tween 80

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

ALX-0081, PMP12A2h1-linker AAA-PMP12A2h1, caplacizumab-yhdp, CAS: 915810-67-2

Clone ID

Caplacizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Caplacizumab
References

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 30625070

Caplacizumab: First Global Approval, PMID: 30298461

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 26863353

Caplacizumab in adult patients with acquired thrombotic thrombocytopenic purpura, PMID: 32095224

Caplacizumab: an anti-von Willebrand factor antibody for the treatment of thrombotic thrombocytopenic purpura, PMID: 32588878

Caplacizumab: a change in the paradigm of thrombotic thrombocytopenic purpura treatment, PMID: 31359806

A regimen with caplacizumab, immunosuppression, and plasma exchange prevents unfavorable outcomes in immune-mediated TTP, PMID: 33150928

Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura, PMID: 31250841

Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura, PMID: 33280030

Real-world experience with caplacizumab in the management of acute TTP, PMID: 33150355

Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura, PMID: 32634236

Efficacy and safety of open-label caplacizumab in patients with exacerbations of acquired thrombotic thrombocytopenic purpura in the HERCULES study, PMID: 31691462

Caplacizumab, PMID: 30933455

ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP, PMID: 32634237

Clinical pharmacology of caplacizumab for the treatment of patients with acquired thrombotic thrombocytopenic purpura, PMID: 30977686

A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura, PMID: 32876503

Should all patients with immune-mediated thrombotic thrombocytopenic purpura receive caplacizumab?, PMID: 33236389

Caplacizumab (Cablivi) for iTTP, PMID: 33429409

Caplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura, PMID: 31118566

Caplacizumab: frequent local skin reactions, PMID: 32997190

Caplacizumab for relapsing thrombotic thrombocytopenic purpura, PMID: 31177334

Thrombotic thrombocytopenic purpura, PMID: 28416507

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 31042846

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 31042845

Caplacizumab for thrombotic thrombocytopenic purpura, PMID: 33664548

The Therapeutic Potential of Nanobodies, PMID: 31686399

Caplacizumab, PMID: 34251781

Caplacizumab for treatment of thrombotic thrombocytopenic purpura in a patient with anaphylaxis to fresh-frozen plasma, PMID: 32358818

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. Reply, PMID: 31042847

Clinical Efficacy and Safety Profile of Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 31576256

Caplacizumab treatment for acquired refractory thrombotic thrombocytopenic purpura, PMID: 32738052

Refractory Auto-Immune Thrombotic Thrombocytopenic Pupura Successfully Treated With Caplacizumab, PMID: 33195299

Role of caplacizumab in the treatment of acquired thrombotic thrombocytopenic purpura, PMID: 32605495

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura, PMID: 32914526

Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura (HERCULES trial), PMID: 31318128

Pharmacoeconomic Review Report: Caplacizumab (Cablivi): (Sanofi Genzyme, a division of Sanofi-Aventis Canada Inc.) [Internet], PMID: 33570888

New Therapeutic Targets and Treatment Options for Thrombotic Microangiopathy: Caplacizumab and Ravulizumab, PMID: 32715723

Counting the cost of caplacizumab, PMID: 33599760

Antibodies to watch in 2019, PMID: 30516432

Caplacizumab Therapy without Plasma Exchange for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 31269374

Correction to: Caplacizumab: First Global Approval, PMID: 30511322

Successful use of caplacizumab in a case of refractory acquired thrombotic thrombocytopenic purpura following subacute thyroiditis, PMID: 33223471

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura, PMID: 32914582

Effective and safe off-label use of caplacizumab treatment in a middle-aged obese male, PMID: 33285299

Clinical Review Report: Caplacizumab (Cablivi): (Sanofi Genzyme, a division of Sanofi-Aventis Canada Inc.) [Internet], PMID: 33600100

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura, PMID: 28445600

Shared decision making, thrombotic thrombocytopenic purpura, and caplacizumab, PMID: 31894592

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura, PMID: 27332911

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer, PMID: 31544819

Caplacizumab for Acute Thrombotic Thrombocytopenic Purpura, PMID: 34109052

Relapse and beyond: Navigating the long-term clinical impacts of immune thrombotic thrombocytopenic purpura., PMID:40505364

Thrombotic Thrombocytopenic Purpura Without Neurological Involvement: A Case Report and Review of the Diagnostic and Treatment Strategies., PMID:40486424

The TMA team and TTP pathway improved outcomes in a cohort with Thrombotic thrombocytopenic purpura., PMID:40478853

Resistant thrombotic thrombocytopenic purpura successfully treated with caplacizumab preceding acute myeloid leukemia., PMID:40444399

Immune Thrombotic Thrombocytopenic Purpura: A Review., PMID:40388146

Early caplacizumab and obinutuzumab enable successful treatment of relapsing thrombotic thrombocytopenic purpura without therapeutic plasma exchange: a case report., PMID:40356910

Cost-Effectiveness and Value of Information Analyses of Caplacizumab for the Treatment of Thrombotic Thrombocytopenic Purpura in Brazil., PMID:40272651

Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysis., PMID:40258188

Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry., PMID:40242663

Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)., PMID:40235949

Optimization of nanobody caplacizumab via computational design., PMID:40226960

Caplacizumab in acute thrombotic throbocytopenic purpura refractory to standard treatment., PMID:40210561

A Descriptive 5-Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the USA: A Multicenter Study of 390 Disease Episodes From 2017 to 2021., PMID:40145682

Challenges in managing iTTP: insights into ADAMTS13 inhibitor boosting during caplacizumab therapy., PMID:40105947

Delayed Recovery of a Disintegrin-Like and Metalloproteinase With Thrombospondin Type 1 Motif 13 (ADAMTS13) Activity in Immune Thrombotic Thrombocytopenic Purpura Treated With Caplacizumab and Rituximab., PMID:40091942

Early administration of caplacizumab combined with plasma exchange for thrombotic microangiopathy due to malignant hypertension: a case report., PMID:40029564

Cost-effectiveness of caplacizumab in immune thrombotic thrombocytopenic purpura in the United States., PMID:40021467

Immune-mediated TTP secondary to checkpoint inhibitor use in a patient with stage IV melanoma., PMID:40000048

Preventative and therapeutic effects of a novel humanized anti-glycoprotein Ibα fragment of antigen-binding region in a murine model of thrombotic thrombocytopenic purpura., PMID:39956431

Research trends in the use of nanobodies for cancer therapy., PMID:39922288

Impact of new medications on the treatment of immune TTP., PMID:39912777

Characterization of bleeding in thrombotic thrombocytopenic purpura in the precaplacizumab era: a retrospective nationwide analysis., PMID:39830971

A Rare But Fatal Toxicity: Immune Checkpoint Inhibitor-Related Acquired Thrombotic Thrombocytopenic Purpura., PMID:39811422

GC1126A, a novel ADAMTS13 mutein, evades autoantibodies in immune-mediated thrombotic thrombocytopenic purpura., PMID:39794345

Thrombotic thrombocytopenic purpura with juvenile systemic lupus erythematosus: successful treatment with caplacizumab and rituximab., PMID:39696445

Complex immunogenicity assessment in caplacizumab-treated patients with immune-mediated thrombotic thrombocytopenic purpura who have received plasma exchange., PMID:39687921

Coronavirus Disease 2019-Associated Thrombotic Microangiopathy: A Single-Center Experience., PMID:39596538

Bortezomib for rituximab-refractory immune-mediated thrombotic thrombocytopenic purpura in the caplacizumab era: an Italian multicenter study., PMID:39549837

A high-performance protein preparation approach in a single column-free step., PMID:39537535

Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination-Associated Thrombotic Microangiopathy., PMID:39534187

Real-World Data on Effectiveness and Safety of First-Line Use of Caplacizumab in Italian Centers for the Treatment of Thrombotic Thrombocytopenic Purpura: The Roscapli Study., PMID:39518700

[100 years thrombotic thrombocytopenic purpura (TTP) - lessons learned?]., PMID:39504978

Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years., PMID:39455963

Taylor A, Keogh L, Dickens E, et al. Caplacizumab in pediatric immune thrombotic thrombocytopenic purpura: the UK TTP Registry experience. Blood Adv. 2024;8(17):4563-4567., PMID:39453632

[Not Available]., PMID:39442507

Vitamin B12 Deficiency in Thrombotic Thrombocytopenic Purpura-Like Cases., PMID:39372153

A Rare Intersection: Managing Thrombotic Thrombocytopenic Purpura in the Context of Dengue Fever., PMID:39371874

Refining the standard of care in immune thrombotic thrombocytopenic purpura., PMID:39356816

An exploration into CTEPH medications: Combining natural language processing, embedding learning, in vitro models, and real-world evidence for drug repurposing., PMID:39264975

Initial US tertiary health care system experience using caplacizumab in patients with immune thrombotic thrombocytopenic purpura., PMID:39259327

Caplacizumab as an add-on therapy in a 7-year-old girl with exacerbated immune-mediated thrombotic thrombocytopenic purpura, a case report and literature review., PMID:39233868

Caplacizumab improves clinical outcomes and is well tolerated across clinically relevant subgroups of patients with immune-mediated thrombotic thrombocytopenic purpura., PMID:39221451

Clinical, biological, prognostic characteristics of patients with immune-mediated thrombotic thrombocytopenic purpura and Sjögren's disease., PMID:39209728

TTP and pregnancy., PMID:39197429

Iatrogenic hemorrhage and extensive venous thromboembolism during iTTP treatment with caplacizumab-A case report., PMID:39157617

ADAMTS13 in the New Era of TTP., PMID:39125707

Immune thrombotic thrombocytopenic purpura: pathogenesis and novel therapies: a narrative review., PMID:39100389

Frontline use of rituximab may prevent ADAMTS13 inhibitor boosting during caplacizumab treatment in patients with iTTP: post hoc analysis of a phase 2/3 study in Japan., PMID:39095866

The history of thrombotic thrombocytopenic purpura research: a narrative review., PMID:39049905

Datasheet

Document Download

Research Grade Caplacizumab.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

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Research Grade Caplacizumab [DHC08501]
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