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Research Grade Inotuzumab

Catalog #:   DHD38502 Specific References (99) DATASHEET
Host species: Humanized
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD38502

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

Sialic acid-binding Ig-like lectin 2, Siglec-2, CD22, T-cell surface antigen Leu-14, BL-CAM, SIGLEC2, B-lymphocyte cell adhesion molecule, B-cell receptor CD22

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P20273

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CMC-544, Inotuzumab Ozogamicin, CAS: 1660159-36-3

Clone ID

Inotuzumab

Data Image
  • SDS-PAGE
    SDS PAGE for Inotuzumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia, PMID: 27292104

Inotuzumab ozogamicin in combination with low-intensity chemotherapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukaemia: a single-arm, phase 2 study, PMID: 29352703

Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study, PMID: 30920645

Inotuzumab Ozogamicin: A Review in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia, PMID: 30090971

Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini-Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Phase 2 Clinical Trial, PMID: 28859185

Inotuzumab ozogamicin for acute lymphoblastic leukaemia, PMID: 31427847

Chemoimmunotherapy with inotuzumab ozogamicin combined with mini-hyper-CVD, with or without blinatumomab, is highly effective in patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first salvage, PMID: 30307611

Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia, PMID: 30267011

Role of blinatumomab, inotuzumab, and CAR T-cells: Which to choose and how to sequence for patients with relapsed disease, PMID: 33256906

Inotuzumab Ozogamicin, PMID: 31643242

Inotuzumab ozogamicin for relapsed/refractory acute lymphoblastic leukemia: outcomes by disease burden, PMID: 32769965

Inotuzumab Ozogamicin: First Global Approval, PMID: 28819740

Inotuzumab Ozogamicin, PMID: 29999985

Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis, PMID: 30985931

Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B-acute lymphoblastic leukemia, PMID: 33098744

Inotuzumab ozogamicin in the treatment of relapsed/refractory acute B cell lymphoblastic leukemia, PMID: 29713210

Efficacy of inotuzumab ozogamicin in patients with Philadelphia chromosome-positive relapsed/refractory acute lymphoblastic leukemia, PMID: 33231879

Inotuzumab: from preclinical development to success in B-cell acute lymphoblastic leukemia, PMID: 30622147

Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma, PMID: 31011424

Impact of minimal residual disease status in patients with relapsed/refractory acute lymphoblastic leukemia treated with inotuzumab ozogamicin in the phase III INO-VATE trial, PMID: 31790983

The Clinical and Cost Effectiveness of Inotuzumab Ozogamicin for the Treatment of Adult Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia: An Evidence Review Group Evaluation of a NICE Single Technology Appraisal, PMID: 30887470

Hepatic adverse event profile of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukaemia: results from the open-label, randomised, phase 3 INO-VATE study, PMID: 28687420

Hepatic veno-occlusive disease in allogeneic stem cell transplant recipients with prior exposure to gemtuzumab ozogamicin or inotuzumab ozogamicin, PMID: 32988266

A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study), PMID: 33067614

Outcomes of Allogeneic Stem Cell Transplantation after Inotuzumab Ozogamicin Treatment for Relapsed or Refractory Acute Lymphoblastic Leukemia, PMID: 31039409

Immunotherapy in pediatric acute lymphoblastic leukemia, PMID: 31811553

Inotuzumab ozogamicin in acute lymphoblastic leukaemia, PMID: 30956118

Inotuzumab ozogamicin: a CD22 mAb-drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia, PMID: 30087554

Inotuzumab ozogamicin for the treatment of acute lymphoblastic leukemia, PMID: 29092647

Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia, PMID: 28152223

Adult Acute Lymphoblastic Leukemia, PMID: 27814839

Inotuzumab ozogamicin in the management of acute lymphoblastic leukaemia, PMID: 26654587

Inotuzumab ozogamicin in the treatment of acute lymphoblastic leukemia, PMID: 24389139

Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia, PMID: 30675645

Recent advances in the treatment of acute lymphoblastic leukemia, PMID: 31092071

Blinatumomab or Inotuzumab Ozogamicin as Bridge to Allogeneic Stem Cell Transplantation for Relapsed or Refractory B-lineage Acute Lymphoblastic Leukemia: A Retrospective Single-Center Analysis, PMID: 32646833

Inotuzumab ozogamicin (Besponsa)--an antibody-drug conjugate for ALL, PMID: 29913470

Role of inotuzumab ozogamicin in the treatment of relapsed/refractory acute lymphoblastic leukemia, PMID: 26780449

Inotuzumab ozogamicin in B-cell acute lymphoblastic leukemias and non-Hodgkin's lymphomas, PMID: 25775418

Inotuzumab ozogamicin in the treatment of B-cell acute lymphoblastic leukemia, PMID: 22500551

Precision medicine in acute lymphoblastic leukemia, PMID: 33074527

Inotuzumab Ozogamicin in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia, PMID: 31186988

Inotuzumab ozogamicin as novel therapy in lymphomas, PMID: 20528256

CD22 Expression in B-Cell Acute Lymphoblastic Leukemia: Biological Significance and Implications for Inotuzumab Therapy in Adults, PMID: 32012891

Inotuzumab ozogamicin, a nonchemotherapy option for relapsed acute lymphoblastic leukemia, PMID: 31188803

Inotuzumab ozogamicin for the treatment of acute lymphoblastic leukemia, PMID: 33815734

Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies, PMID: 25304309

Inotuzumab ozogamicin for the treatment of patients with acute lymphocytic leukemia, PMID: 29517084

Inotuzumab ozogamicin compassionate use for French paediatric patients with relapsed or refractory CD22-positive B-cell acute lymphoblastic leukaemia, PMID: 32424837

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions, PMID: 32503572

Outcome of second allogeneic hematopoietic cell transplantation in adult patients with relapsed B-cell acute lymphoblastic leukemia in the era of new immunotherapeutic agents., PMID:40527981

Pharmacovigilance insights into antibody-drug conjugates: a multi-database analysis of adverse events in leukemia treatment., PMID:40522479

Comparing Outcomes of First-Line Intensive Chemotherapeutic Regimens in Adult Patients With Acute Lymphoblastic Leukemia at a Tertiary Center., PMID:40500615

Treatment of Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia., PMID:40494331

Acute Lymphoid Leukemia: Is Transplant Indicated for Philadelphia Chromosome Positive ALL?, PMID:40488828

Advances and challenges in leukemia treatment: A focus on monoclonal antibodies and emerging therapies., PMID:40486885

Recent advances in monoclonal antibody development for treatment of B-cell acute lymphoblastic leukemia., PMID:40455243

Revumenib for Relapsed or Refractory Acute Leukemia With a KMT2A Translocation., PMID:40437770

Differentiation-dependent EBF1 Activity Determines CD22 Transcription and Leukemia Sensitivity to Inotuzumab Ozogamicin., PMID:40435412

Identifying people with acute lymphoblastic leukemia who are most suitable for treatment with inotuzumab ozogamicin: a plain language summary., PMID:40394810

Inotuzumab therapy resulted in molecular remission of relapsed/resistant B-cell acute lymphoblastic leukemia with BCR::ABL1 Lys404Glu mutation., PMID:40377672

Adult Acute Lymphoblastic Leukemia: 2025 Update on Diagnosis, Therapy, and Monitoring., PMID:40377367

Safety evaluation of inotuzumab ozogamicin: a pharmacovigilance study based on the FAERS database., PMID:40359557

Treatment of Older Patients With ALL., PMID:40354595

Beyond Cellular Therapies: The Expanding Role of Antibody-Driven Immunotherapy in Pediatric Acute Lymphoblastic Leukemia., PMID:40324358

The evolving therapeutic revolution in adult acute lymphoblastic leukemia., PMID:40323723

Management of Adult Acute Lymphoblastic Leukemia: A Review., PMID:40310617

Pre-transplant blinatumomab and/or inotuzumab ozogamicin therapy for relapsed/refractory acute lymphoblastic and B/myeloid mixed phenotype acute leukemia in adults., PMID:40306011

Hepatic sinusoidal congestion associated with inotuzumab therapy in patients with B-cell acute lymphoblastic leukemia, a proposal for a new clinical entity: Calicheamicin syndrome., PMID:40296727

Bispecific antibodies in immunotherapy for acute leukemia: latest updates from the 66th annual meeting of the American society of hematology, 2024., PMID:40270605

Atypical features of hepatic veno-occlusive disease/sinusoidal obstruction syndrome after inotuzumab ozogamicin in adult patients with acute lymphoblastic leukemia., PMID:40261550

CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy., PMID:40246579

Differences in response to immunotherapy drugs including blinatumomab and inotuzumab ozogamicin in B-ALL patients., PMID:40232601

Inferior Outcomes in Acute Lymphoblastic Leukemia With Translocation (14;18)., PMID:40222876

Real-world outcomes for young adult patients receiving CD19 CAR T-cell therapy., PMID:40127395

INO-CD22: A multicenter, real-world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed/refractory acute lymphoblastic leukemia., PMID:40120068

CIBMTR Registry Data on Inotuzumab Ozogamicin Treatment in Patients with ALL Who Proceeded to Hematopoietic Stem Cell Transplant-A Podcast., PMID:40111710

Inotuzumab Ozogamicin as a Bridge to Stem Cell Transplantation in Relapsed Pediatric BCP-ALL After Tisagenlecleucel: A Case Series., PMID:40085546

Antibody-Based and Other Novel Agents in Adult B-Cell Acute Lymphoblastic Leukemia., PMID:40075627

Therapeutic Strategies for Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia in Adult Patients: Optimizing the Use of Monoclonal Antibodies., PMID:40045912

Gastrointestinal toxicity of antibody-drug conjugates: a pharmacovigilance study using the FAERS database., PMID:40033454

Five-Year Real-World Safety of Inotuzumab Ozogamicin Before Hematopoietic Stem Cell Transplantation in B-Cell Precursor Acute Lymphoblastic Leukemia., PMID:39989181

Therapeutic drug monitoring in acute lymphoblastic leukemia-a deep dive into pharmacokinetics, -dynamics, and -genetics of antileukemic drugs., PMID:39949259

Inotuzumab Ozogamicin as First-Line Therapy in Acute Lymphoblastic Leukemia., PMID:39909815

Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery., PMID:39895690

Efficacy and safety of currently approved and lower starting doses of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukemia: a phase IV study., PMID:39882642

CD58 expression does not impact response to inotuzumab ozogamicin in patients with B-cell acute lymphoblastic leukemia., PMID:39866945

Utility of ursodiol prophylaxis against sinusoidal obstruction syndrome (SOS)/ veno-occlusive disease (VOD) in acute leukemia patients receiving gemtuzumab-ozogamicin (GO) or inotuzumab-ozogamicin (InO)., PMID:39819278

Role of Allogeneic Hematopoietic Stem Cell Transplantation for Philadelphia Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia in the Contemporary Era., PMID:39796731

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia., PMID:39791601

Frontline immunotherapeutic combination strategies in adult B-cell acute lymphoblastic leukemia: reducing chemotherapy intensity and toxicity and harnessing efficacy., PMID:39791458

Characterizing the ideal patient for treatment with inotuzumab ozogamicin for relapsed/refractory acute lymphoblastic leukemia: a systematic literature review., PMID:39778191

Hyper-CVAD and Sequential Blinatumomab Without and With Inotuzumab in Young Adults With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia., PMID:39757533

Philadelphia Chromosome as a Clinically Favorable Prognostic Factor of B-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in Transplant-Ineligible Elderly Patients in the Era of Molecular-Targeted Therapy., PMID:39703243

Contributions of Pediatric Hematology/Oncology to the Diagnosis, Treatment, and Cure of Acute Lymphoblastic Leukemia-Part 2b (Numbers 16 to 20)., PMID:39652786

Inotuzumab ozogamicin for relapse prevention in a boy with Down syndrome and relapsed acute lymphoblastic leukemia., PMID:39648271

Antibody-Drug Conjugates: The Toxicities and Adverse Effects That Emergency Physicians Must Know., PMID:39641680

Blinatumomab for the treatment of acute lymphoblastic leukemia in a real-world setting: clinical vignettes., PMID:39611241

Exploring the role of PARP1 inhibition in enhancing antibody-drug conjugate therapy for acute leukemias: insights from DNA damage response pathway interactions., PMID:39587643

Datasheet

Document Download

Research Grade Inotuzumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Inotuzumab [DHD38502]
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