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Research Grade Benralizumab

Catalog #:   DHF86301 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHF86301

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R

Concentration

1.17 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q01344

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

BIW-8405, KHK4563, MEDI-563, CAS: 1044511-01-4

Clone ID

Benralizumab

Data Image
  • Bioactivity
    Detects Human CD125/IL5RA in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Benralizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma, PMID: 28530840

Benralizumab for the Prevention of COPD Exacerbations, PMID: 31112385

Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma, PMID: 32034960

Real-World Effectiveness of Benralizumab in Severe Eosinophilic Asthma, PMID: 32882249

Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome, PMID: 30943337

Benralizumab for asthma, PMID: 30410214

Benralizumab: an updated treatment of eosinophilic asthma, PMID: 32133878

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β 2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial, PMID: 27609408

Benralizumab for Chronic Spontaneous Urticaria, PMID: 32997916

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial, PMID: 27609406

Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma, PMID: 31017107

Asthma exacerbations on benralizumab are largely non-eosinophilic, PMID: 32767484

Benralizumab as a Steroid-Sparing Treatment Option in Eosinophilic Granulomatosis with Polyangiitis, PMID: 33065367

Benralizumab: First Global Approval, PMID: 29464664

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial, PMID: 30416083

Benralizumab, PMID: 31643952

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial, PMID: 33357499

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab, PMID: 32242310

Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study, PMID: 32746787

Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma, PMID: 32064642

Benralizumab, PMID: 30000011

Benralizumab after sub-optimal response to mepolizumab in severe eosinophilic asthma, PMID: 33300186

Benralizumab efficacy for patients with fixed airflow obstruction and severe, uncontrolled eosinophilic asthma, PMID: 31626906

Benralizumab for the treatment of asthma, PMID: 28379047

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia, PMID: 23866823

Ability of Serum IgE Concentration to Predict Exacerbation Risk and Benralizumab Efficacy for Patients with Severe Eosinophilic Asthma, PMID: 31836949

Benralizumab for the treatment of asthma, PMID: 29517082

Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial, PMID: 31579676

Two-year integrated steroid-sparing analysis and safety of benralizumab for severe asthma, PMID: 31859541

Benralizumab in Real Life, PMID: 32573458

Blood Eosinophil Depletion with Mepolizumab, Benralizumab, and Prednisolone in Eosinophilic Asthma, PMID: 32584603

Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a systematic review, PMID: 30309978

Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma, PMID: 30139780

Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies, PMID: 28919200

Mabs for treating asthma: omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, PMID: 32401603

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study, PMID: 25306557

Benralizumab: an anti-IL-5 receptor α monoclonal antibody in the treatment of asthma, PMID: 29359607

Benralizumab, an add-on treatment for severe eosinophilic asthma: evaluation of exacerbations, emergency department visits, lung function, and oral corticosteroid use, PMID: 30425502

Benralizumab as a potential treatment of asthma, PMID: 28406319

Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?, PMID: 31024635

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases, PMID: 30658649

The relationship between Feno and effectiveness of mepolizumab and benralizumab in severe eosinophilic asthma, PMID: 33486140

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy, PMID: 29606855

Real-life experience with benralizumab during 6 months, PMID: 32600318

Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma, PMID: 29862274

Rapid effect of benralizumab for severe asthma with chronic rhinosinusitis with nasal polyps, PMID: 33039667

Benralizumab for the add-on maintenance treatment of patients with severe asthma aged 12 years and older with an eosinophilic phenotype, PMID: 29972739

Benralizumab as initial treatment for chronic eosinophilic pneumonia, PMID: 32807690

Benralizumab strongly reduces blood basophils in severe eosinophilic asthma, PMID: 32762056

Anti-IL5 therapies for asthma, PMID: 28933516

Cost-effectiveness of mepolizumab vs anti-interleukin-5/5r biologic therapies for the treatment of adults with severe asthma with an eosinophilic phenotype: a Chilean healthcare system perspective., PMID:40528625

Corrigendum to "Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial" [Allergol Int 74 (2025) 274-82]., PMID:40517040

ICS use trajectories in severe asthma patients on benralizumab: real-life data from 3-years follow-up., PMID:40513966

Aspirin-Exacerbated Respiratory Disease in the era of biologics., PMID:40490219

Advancements in Biologic Therapies for Pediatric Asthma: Emerging Therapies and Future Directions., PMID:40486460

Benralizumab treatment and 3-dimensional bronchial tree changes in chronic eosinophilic pneumonia., PMID:40476092

Development of Eosinophilic Granulomatosis With Polyangiitis Despite Anti-Interleukin-5 Receptor Therapy: The First Case of Bilateral Central Retinal Artery Occlusion During Benralizumab Treatment., PMID:40461442

Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement., PMID:40457436

Efficacy of Benralizumab in Reducing FeNO in Severe Eosinophilic Asthma: The Role of CRSwNP., PMID:40454227

Advancing Remission in Severe Asthma With Benralizumab: Latest Findings, Current Perspectives and Future Direction., PMID:40444568

Hypereosinophilia: clinical and therapeutic approach in 2025., PMID:40396537

Benralizumab for acute thromboembolism in hypereosinophilic syndrome: a case report., PMID:40382631

Long-Term Longitudinal Analysis of Pulmonary Function Before and After Biological Therapy in Severe Asthma., PMID:40373751

Biologic Therapies for Severe Asthma: Current Insights and Future Directions., PMID:40364184

Early and Sustained Clinical Benefits of Benralizumab in Severe Eosinophilic Asthma: Findings from the ORBE II Study., PMID:40364043

Requalification of patients with severe asthma for biological therapy-Practical 'ReQuaBi' rate decision scheme based on the analytical model., PMID:40348613

High local type-2 inflammation is linked to response in severe asthma treated with anti-Interleukin-5 receptor., PMID:40345261

Reappraisal of Biologic Efficacy from Phase 3 Trials in Refractory Chronic Rhinosinusitis and Nasal Polyps., PMID:40340024

Comparative Insights on IL-5 Targeting with Mepolizumab and Benralizumab: Enhancing EGPA Treatment Strategies., PMID:40305320

Pathway to Remission in Severe Asthma: Clinical Effectiveness and Key Predictors of Success with Benralizumab Therapy: A Real-Life Study., PMID:40299478

Long-term efficacy and safety of different biologics in treatment of chronic rhinosinusitis with nasal polyps: A network meta-analysis., PMID:40286594

Biologic Agents in Idiopathic Hypereosinophilic Syndrome., PMID:40283978

New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review., PMID:40281872

Efficacy of Biologics in Reducing Exacerbations Requiring Hospitalization or an Emergency Department Visit in Patients with Moderate or Severe, Uncontrolled Asthma., PMID:40261563

XALOC-1: Clinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma., PMID:40258512

Exploring a novel approach to COPD treatment: benralizumab effect in an ex vivo 3-D model., PMID:40254172

Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma., PMID:40251899

Comparative Effectiveness of Dupilumab Versus Mepolizumab and Benralizumab in Asthma: A Multinational Retrospective Cohort Study., PMID:40250559

Effectiveness of tezepelumab in preventing relapse of eosinophilic granulomatosis with polyangiitis: A case report., PMID:40239417

Treatment of allergic bronchopulmonary aspergillosis with biologics., PMID:40226607

Utility of the Basophil Reactivity Test in the Clinical Management of People with Severe Uncontrolled Asthma., PMID:40224171

Real-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry., PMID:40217624

Combining Dual Biologics Therapy for Severe Asthma: A Series of Ten Cases., PMID:40206518

Benralizumab and the integrated management of co-morbid severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps., PMID:40200389

Dual biological treatments in immune-mediated disorders: a single center experience., PMID:40200173

Effect of benralizumab treatment on the airway microbiome in COPD., PMID:40196715

Long-term, real-world effectiveness of biologics for severe uncontrolled asthma: The PROSPECT study., PMID:40186961

Head-to-Head Effectiveness Comparison of Biological Therapies in Patients With Mixed Eosinophilic and Allergic Severe Asthma., PMID:40185202

Durability of benralizumab effectiveness in severe eosinophilic asthma patients with and without chronic rhinosinusitis with nasal polyps: a post hoc analysis from the ANANKE study., PMID:40181809

Pulmonology: What You May Have Missed in 2024., PMID:40163874

Benralizumab for the treatment of chronic spontaneous urticaria: a plain language summary of the ARROYO study., PMID:40159728

Head-To-Head Comparison of Biologic Efficacy in Asthma: What Have We Learned?, PMID:40156481

Severe Asthma and Active SARS-CoV-2 Infection: Insights into Biologics., PMID:40149651

Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study., PMID:40147217

Long-Term Clinical Remission on Benralizumab Treatment in Severe Eosinophilic Asthma: A Four-Year Real-Life Study., PMID:40142883

Clinical efficacy and mechanisms of biologics for chronic rhinosinusitis with nasal polyps., PMID:40132672

Long-Term Efficacy and Safety of Benralizumab Treatment for PDGFRA-Negative Hypereosinophilic Syndrome., PMID:40120806

Adverse effects of biologics used to treat asthma., PMID:40099886

Effect of Biologics against Interleukin-5 Administered to Patients with Eosinophilic Gastroenteritis1., PMID:40090714

Real-World Effectiveness of Biologic Therapy in Allergic Bronchopulmonary Aspergillosis., PMID:40088970

Datasheet

Document Download

Research Grade Benralizumab.pdf

 

$ 372
Product specifications
100 μg 372 1 mg 1486

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Research Grade Benralizumab [DHF86301]
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