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Research Grade Elotuzumab

Catalog #:   DHJ64001 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ64001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

SLAMF7, CRACC, Protein 19A, SLAM family member 7, CD2-like receptor-activating cytotoxic cells, Membrane protein FOAP-12, CD319, Novel Ly9, CD2 subset 1, CS1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NQ25

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

BMS-901608, PDL063, HuLuc63, CAS: 915296-00-3

Clone ID

Elotuzumab

Data Image
  • Bioactivity
    Detects Human CD319/SLAMF7 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Elotuzumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma, PMID: 30403938

Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma, PMID: 26035255

The Clinical Pharmacology of Elotuzumab, PMID: 28779463

Elotuzumab, PMID: 31644037

Elotuzumab: A Review in Relapsed and/or Refractory Multiple Myeloma, PMID: 30232695

Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma, PMID: 30455698

Elotuzumab, PMID: 29999843

Bortezomib, lenalidomide, and dexamethasone with or without elotuzumab in patients with untreated, high-risk multiple myeloma (SWOG-1211): primary analysis of a randomised, phase 2 trial, PMID: 33357482

The role of elotuzumab in the treatment of relapsed or refractory multiple myeloma, PMID: 29317395

Elotuzumab, lenalidomide, and dexamethasone in RRMM: final overall survival results from the phase 3 randomized ELOQUENT-2 study, PMID: 32887873

Elotuzumab in combination with pomalidomide and dexamethasone for the treatment of multiple myeloma, PMID: 31679403

Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 4-year follow-up and analysis of relative progression-free survival from the randomized ELOQUENT-2 trial, PMID: 30204239

Elotuzumab: First Global Approval, PMID: 26809244

Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling, PMID: 29531651

Elotuzumab as a novel anti-myeloma immunotherapy, PMID: 28604269

Elotuzumab: the first approved monoclonal antibody for multiple myeloma treatment, PMID: 27493709

Elotuzumab-based maintenance therapy following autologous stem cell transplant in multiple myeloma deepens post-transplant responses, PMID: 32745939

Development of [ 89 Zr]DFO-elotuzumab for immunoPET imaging of CS1 in multiple myeloma, PMID: 33179150

Elotuzumab for the treatment of multiple myeloma, PMID: 27417553

Update on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients' selection and perspective, PMID: 31410026

Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM, PMID: 27091875

Efficacy and safety of elotuzumab for the treatment of multiple myeloma, PMID: 28060563

Elotuzumab in multiple myeloma, PMID: 30449660

Multiple Myeloma: Diagnosis and Treatment, PMID: 26763514

Second elotuzumab triplet efficacious in MM, PMID: 30478425

Treatment of multiple myeloma with the immunostimulatory SLAMF7 antibody elotuzumab, PMID: 27695618

Spotlight on elotuzumab in the treatment of multiple myeloma: the evidence to date, PMID: 27785050

Daratumumab, Elotuzumab, and the Development of Therapeutic Monoclonal Antibodies in Multiple Myeloma, PMID: 27806428

Elotuzumab: a novel immune-stimulating therapy to treat multiple myeloma, PMID: 27322214

Elotuzumab: a novel anti-CS1 monoclonal antibody for the treatment of multiple myeloma, PMID: 24151843

Immunotherapy: A New Approach to Treating Multiple Myeloma with Daratumumab and Elotuzumab, PMID: 27083916

Update on elotuzumab, a novel anti-SLAMF7 monoclonal antibody for the treatment of multiple myeloma, PMID: 27533882

Toward further simplification of elotuzumab therapy by subcutaneous administration, PMID: 32656639

Treatment of relapsed and refractory multiple myeloma, PMID: 32719176

Model-Based Determination of Elotuzumab Pharmacokinetics in Japanese Patients With Multiple Myeloma Incorporating Time-Varying M Protein, PMID: 32656777

Treatment of relapsed multiple myeloma: Evidence-based recommendations, PMID: 31500848

Mechanisms of Action and Clinical Development of Elotuzumab, PMID: 29272564

Elotuzumab in the treatment of relapsed and refractory multiple myeloma, PMID: 33478270

Frequent occurrence of hypophosphatemia among multiple myeloma patients treated with elotuzumab: a single clinic retrospective study, PMID: 33237342

Sequence matters: elotuzumab more effective if used before daratumumab, PMID: 31845607

How to Integrate Elotuzumab and Daratumumab Into Therapy for Multiple Myeloma, PMID: 27998219

Managing Infusion Reactions to New Monoclonal Antibodies in Multiple Myeloma: Daratumumab and Elotuzumab, PMID: 29996069

Elotuzumab for the treatment of multiple myeloma, PMID: 24941981

Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma, PMID: 24053207

Emerging immunotherapies in multiple myeloma, PMID: 32958461

Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy, PMID: 30147690

Elotuzumab: The First Monoclonal Antibody for the Treatment of Multiple Myeloma, PMID: 29282429

A review discussing elotuzumab and its use in the second-line plus treatment of multiple myeloma, PMID: 29091475

Soluble SLAMF7 is a predictive biomarker for elotuzumab therapy, PMID: 32398792

Elotuzumab-induced interstitial lung disease: the first case report, PMID: 29635485

Daratumumab (anti-CD38)- and elotuzumab (anti-SLAMF7)-based treatments for refractory POEMS syndrome: a single-center case series., PMID:40528367

Global Access to Multiple Myeloma Therapies., PMID:40466014

The efficacy of new drug regimens in treating newly diagnosed high-risk cytogenetic multiple myeloma patients: a systematic literature review and meta-analysis., PMID:40432724

Real world outcomes with elotuzumab-based therapies for patients with relapsed refractory multiple myeloma: a Mayo Clinic experience., PMID:40410136

Using bispecific antibodies in a patient with peritoneal dialysis for relapsed multiple myeloma., PMID:40356496

Comparative Efficacy of Ciltacabtagene Autoleucel Versus Standard-of-Care Treatments for Patients with Previously Treated Relapsed or Refractory Multiple Myeloma: A Matching-Adjusted Indirect Comparison., PMID:40354013

Pulmonary adverse events associated with monoclonal antibodies approved for multiple myeloma: a pharmacovigilance study based on the FDA adverse event reporting system., PMID:40302414

Elotuzumab in Combination With Dose Reduced IMiDs and Dexamethasone for AL Amyloidosis Patients With Relapsed/Refractory Plasma Cell Dyscrasia and Advanced Organ Involvement., PMID:40276975

Prognostic Significance of +1q Alterations in Relapsed/Refractory Multiple Myeloma Treated With Daratumumab-, Elotuzumab-, and Carfilzomib-Based Triplet Regimens: A Multicenter Real-World Analysis of 635 Patients., PMID:40103518

Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System., PMID:40095047

Cost-effectiveness analysis of combination therapies involving novel agents for first/second-relapse patients with multiple myeloma: a Markov model approach with calibration techniques., PMID:40088315

The multifaceted role of CS1 (SLAMF7) in immunoregulation: Implications for cancer therapy and autoimmune disorders., PMID:40073958

Memory-like NK cell differentiation, inhibitory NKG2A blockade, and improved recognition via antibody or CAR engineering combine to enhance NK cell attack against multiple myeloma., PMID:40073259

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomidedexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data., PMID:40045883

Monoclonal Antibodies in Relapsed-Refractory Multiple Myeloma., PMID:40005960

Monoclonal Antibodies and Small-Molecule Inhibitors Associated Osteonecrosis of Jaw: A Retrospective Pharmacovigilance Study., PMID:39922223

Angioimmunoblastic T-cell lymphoma: Characterization of clonal T and B cells and a patient-derived xenograft study of coexisting T- and B-cell proliferation., PMID:39877932

Correction to Elotuzumab Plus Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Extended Follow-Up of a Multicenter, Retrospective Real-World Experience With 321 Cases Outside of Controlled Clinical Trials., PMID:39846436

Outcomes and prognostic indicators in daratumumab-refractory multiple myeloma: a multicenter real-world study of elotuzumab, pomalidomide, and dexamethasone in 247 patients., PMID:39778329

Advancements in the Treatment of Multiple Myeloma., PMID:39744254

Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma., PMID:39626297

Elotuzumab-mediated ADCC with Th1-like Vγ9Vδ2 T cells to disrupt myeloma-osteoclast interaction., PMID:39557586

Novel Drug Combinations and Donor Lymphocyte Infusions Allow Prolonged Disease Control in Multiple Myeloma Patients Relapsing after Allogeneic Transplantation., PMID:39505212

In vitro testing of drug response in primary multiple myeloma cells using a microwell-based technology., PMID:39486120

Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System., PMID:39458907

The Real-World Outcomes of Relapsed/Refractory Multiple Myeloma Treated with Elotuzumab, Pomalidomide, and Dexamethasone., PMID:39449301

Addition of Elotuzumab to Backbone Treatment Regimens for Multiple Myeloma: An Updated Meta-Analysis of Randomized Clinical Trials., PMID:39414558

Cardiovascular adverse events associated with targeted therapies for multiple myeloma: a pharmacovigilance study., PMID:39391316

Dexamethasone dose intensity does not impact outcomes in newly diagnosed multiple myeloma: a secondary SWOG analysis., PMID:39321347

Phase II trial of elotuzumab with pomalidomide and dexamethasone for daratumumab-refractory multiple myeloma., PMID:39237502

Disseminated Nontuberculous Mycobacterium Infection During Treatment of Multiple Myeloma: A Case Report and Review of the Literature., PMID:39231663

From Triple- to Penta-Exposed Multiple Myeloma: A Real-World Study in a Medicare Population., PMID:39097860

Post-ASCT consolidation with elotuzumab, lenalidomide, and dexamethasone or elotuzumab, pomalidomide, and dexamethasone in high-risk and ultra-high-risk multiple myeloma: a retrospective single-center study., PMID:39082756

Descriptive Analysis of Adverse Events Reported for New Multiple Myeloma Medications Using FDA Adverse Event Reporting System (FAERS) Databases from 2015 to 2022., PMID:39065666

Improvement of daratumumab- or elotuzumab-mediated NK cell activity by the bi-specific 4-1BB agonist, DARPin α-FAPx4-1BB: A preclinical study in multiple myeloma., PMID:38850654

Nivolumab, Pomalidomide, and Elotuzumab Combination Regimens for Treatment of Relapsed and Refractory Multiple Myeloma: Results from the Phase 3 CheckMate 602 Study., PMID:38849283

Elotuzumab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended follow-up of a multicenter, retrospective real-world experience with 321 cases outside of controlled clinical trials., PMID:38818978

CS1 Expression Pattern in NK Cells and Correlated Factors in Plasma Cell dyscrasias: Implications for Elotuzumab Therapy and CAR-T Efficacy., PMID:38706917

Cytomegalovirus Reactivation during Elotuzumab Therapy in Patients with Multiple Myeloma., PMID:38657575

Daratumumab‑resistant multiple myeloma with extramedullary disease successfully treated with combination elotuzumab, pomalidomide and dexamethasone: A case report., PMID:38638843

Therapeutic progress in relapsed/refractory multiple myeloma., PMID:38609727

Phase 1 study combining elotuzumab with autologous stem cell transplant and lenalidomide for multiple myeloma., PMID:38609316

Characteristics of isatuximab-derived interference in serum protein electrophoresis and immunofixation, and an absence of sustained in vivo interference due to belantamab mafodotin and denosumab., PMID:38565341

Comparative effectiveness of lenalidomide/dexamethasone-based triplet regimens for treatment of relapsed and/or refractory multiple myeloma in the United States: An analysis of real-world electronic health records data., PMID:38547609

Safety and Effectiveness of Elotuzumab in Japanese Patients with Relapsed/Refractory Multiple Myeloma: A Post-marketing Surveillance Study., PMID:38494720

Efficacy of elotuzumab for multiple myeloma deteriorates after daratumumab: a multicenter retrospective study., PMID:38492020

Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes., PMID:38444839

NK and T-lymphocyte Kinetics Predict Outcome in Myeloma Patients Treated With Elotuzumab, Lenalidomide Plus Dexamethasone., PMID:38434915

Health-related quality of life in patients with triple-class exposed relapsed and refractory multiple myeloma treated with idecabtagene vicleucel or standard regimens: patient-reported outcomes from the phase 3, randomised, open-label KarMMa-3 clinical trial., PMID:38423700

Elotuzumab: no additional effect in patients with newly diagnosed multiple myeloma., PMID:38302226

Datasheet

Document Download

Research Grade Elotuzumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Elotuzumab [DHJ64001]
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