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Research Grade Alirocumab

Catalog #:   DHJ24001 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ24001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, NARC-1, PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, NARC1, PCSK9

Concentration

2.18 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8NBP7

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

REGN727, SAR-236553, CAS: 1245916-14-6

Clone ID

Alirocumab

Data Image
  • SDS-PAGE
    SDS PAGE for Alirocumab
References

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome, PMID: 30403574

Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES, PMID: 31707788

Alirocumab for hypercholesterolaemia, PMID: 30765907

Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome, PMID: 31948641

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events, PMID: 25773378

Effect of Alirocumab on Mortality After Acute Coronary Syndromes, PMID: 31117810

Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial, PMID: 31272931

Alirocumab, PMID: 31643517

A Systematic Review of PCSK9 Inhibitors Alirocumab and Evolocumab, PMID: 27231792

Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial, PMID: 30428396

Alirocumab, PMID: 29999811

Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial, PMID: 32646561

Alirocumab for low-density lipoprotein cholesterol lowering, PMID: 30499328

Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol, PMID: 32035487

Alirocumab for the treatment of hypercholesterolemia, PMID: 28277798

Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial, PMID: 30898609

Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial, PMID: 32381160

Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial, PMID: 33051646

Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery, PMID: 31466614

Alirocumab for the treatment of hypercholesterolaemia, PMID: 28395555

An evaluation of alirocumab for the treatment of hypercholesterolemia, PMID: 26563849

Alirocumab in Polyvascular Atherosclerotic Disease, PMID: 31948655

Alirocumab: A Review in Hypercholesterolemia, PMID: 26935836

Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial, PMID: 32223446

Reply: Alirocumab in Polyvascular Atherosclerotic Disease, PMID: 31948656

Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial, PMID: 31707832

Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial, PMID: 32820320

Alirocumab for the treatment of hyperlipidemia in high-risk patients: an updated review, PMID: 29171769

Alirocumab's Price Reduction, PMID: 30354510

Alirocumab as add-on therapy to statins: current evidence and clinical potential, PMID: 29792380

Alirocumab: First Global Approval, PMID: 26370210

Alirocumab (Praluent) for Treatment of Hyperlipidemia, PMID: 27548598

Alirocumab after Acute Coronary Syndrome, PMID: 31116932

Alirocumab after Acute Coronary Syndrome, PMID: 31116931

Alirocumab after Acute Coronary Syndrome, PMID: 31116930

Alirocumab after Acute Coronary Syndrome, PMID: 31116933

Alirocumab after Acute Coronary Syndrome, PMID: 31116929

A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I, PMID: 27639753

Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial, PMID: 25687353

Alirocumab after Acute Coronary Syndrome. Reply, PMID: 31116934

Alirocumab -- Addendum to Commission A15-47 [Internet], PMID: 29144668

Scleritis With Uveal Effusion From Alirocumab, PMID: 32150753

ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia, PMID: 26330422

Alirocumab (Praluent) to lower LDL-Cholesterol, PMID: 26262881

Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial, PMID: 25440796

Alirocumab: targeting PCSK9 to treat hypercholesterolemia, PMID: 26798848

PCSK9 inhibitors: clinical evidence and implementation, PMID: 30420622

The Evolving Future of PCSK9 Inhibitors, PMID: 30012326

Efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels: a network meta-analysis, PMID: 30782243

Alirocumab therapy in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease: analysis of the ODYSSEY DM-DYSLIPIDEMIA and DM-INSULIN studies, PMID: 31706300

Alirocumab versus Evolocumab on Cardiovascular Outcomes: A Systematic Review and Meta-analysis., PMID:40511660

Statins Versus Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors for Primary Cardiovascular Prevention in High-Risk Patients: A Systematic Review., PMID:40486443

Association between novel agents targeting proprotein convertase subtilisin/kexin type 9 and cancer incidence., PMID:40447742

Improvement of retinal microvascular function after initiation of lipid-lowering therapy with PCSK9 inhibitors - An observational study., PMID:40360377

Comparative Efficacy of Non-Statin Lipid-Lowering Therapies in Patients With Hypercholesterolemia at Increased Cardiovascular Risk: An Updated Network Meta-Analysis., PMID:40358978

Effects of Alirocumab and Evolocumab on Cardiovascular Mortality and LDL-C: Stratified According to the Baseline LDL-C Levels., PMID:40351695

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: A drug-target Mendelian randomization study., PMID:40347490

Effectiveness of alirocumab and evolocumab (PCSK9i) for the treatment of hypercholesterolemia., PMID:40339450

Hypercholesterolemia and cardiovascular disease: the dilemma of effective treatment for target achievement according to guidelines and national healthcare policies and a call to action., PMID:40322779

Alirocumab in Adult Patients With Hyperlipidemia After Liver Transplantation: A Short-term Observation., PMID:40307128

Effect of Alirocumab in Atherosclerotic Plaques-Reply., PMID:40305042

Effect of Alirocumab in Atherosclerotic Plaques., PMID:40305033

Effectiveness and safety of long-term therapy with alirocumab in acute coronary syndrome patients: A single-centre retrospective real-world study., PMID:40289287

Corrigendum to "Exploring the benefits of alirocumab as lipid-lowering therapy in people with diabetes and very high cardiovascular risk" [Diabetes Res. Clin. Pract. 222 (2025) 112055]., PMID:40253258

Inadequate Response to PCSK9 Inhibitors., PMID:40250948

NT-proBNP in the Early Convalescent Phase after High-Risk Myocardial Infarction Is Associated with Adverse Cardiovascular Outcomes: the PARADISE-MI Trial., PMID:40250826

Consumption and expenditure of drugs used for the treatment of hypercholesterolemia: a governance analysis., PMID:40222896

Developing a national implementation strategy for enhancing the detection of familial hypercholesterolemia: An Australian experience., PMID:40221339

Safety and effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition: an updated review., PMID:40202526

Target-Mediated Modeling of Alirocumab in Adolescents and Children ≥8 to <12 Years of Age Using Phase II and III Data., PMID:40136083

Immunotherapy and vaccine-based approaches for atherosclerosis prevention: a systematic review study., PMID:40114074

Serum Lipids, Inflammation, and the Risk of Atrial Fibrillation: Pathophysiological Links and Clinical Evidence., PMID:40095683

Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan., PMID:40089775

Relationship of haptoglobin phenotype and levels with sight-threatening diabetic retinopathy in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in diabetes (FIELD) substudy., PMID:40081501

PCSK9 Enhances Cardiac Fibrogenesis via the Activation of Toll-like Receptor and NLRP3 Inflammasome Signaling., PMID:40076547

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial., PMID:40045751

Effects of Inclisiran, Alirocumab, Evolocumab, and Evinacumab on Lipids: A Network Meta-Analysis., PMID:40026525

Exploring the benefits of alirocumab as lipid-lowering therapy in people with diabetes and very high cardiovascular risk., PMID:40020784

Treatment with PCSK9 inhibitors influences microRNAs expression and changes of arterial wall properties: a randomized controlled trial., PMID:40001082

In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss., PMID:39979532

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis., PMID:39975967

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice., PMID:39963241

Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?, PMID:39947256

PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose., PMID:39940773

Considerations on the sustainability of hypercholesterolemia treatment in the context of new drugs on the market: data from Campania, Italy., PMID:39921732

Apolipoprotein C3 and risk of cardiovascular events and death in patients on optimized statin treatment after recent acute coronary syndrome., PMID:39921475

American Association of Clinical Endocrinology Clinical Practice Guideline on Pharmacologic Management of Adults With Dyslipidemia., PMID:39919851

Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial., PMID:39913634

Response to Letter Regarding Article, "Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab"., PMID:39906998

Letter by Natale et al Regarding Article, "Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab"., PMID:39906990

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction., PMID:39906341

Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Lipoprotein(a): A Meta-Analysis and Meta-Regression of Randomized Controlled Trials., PMID:39877671

Lipid-Lowering Efficiency and Safety of Alirocumab 300 mg Using a 2-mL Autoinjector Device in Real-World Practice: The MARS Study., PMID:39875772

Efficacy and safety of PCSK9 inhibitors in real life., PMID:39864963

Effect of Alirocumab Monotherapy vs Ezetimibe Plus Statin Therapy on LDL-C Lowering in Veterans With History of ASCVD., PMID:39839705

Cost-Effectiveness Analysis of Inclisiran for the Treatment of Primary Hypercholesterolemia or Mixed Dyslipidemia in Singapore., PMID:39818637

The Effect of PCSK9 Monoclonal Antibodies on Platelet Reactivity and Cardiovascular Events in Patients Receiving Primary Percutaneous Coronary Intervention: A Propensity Score-Matched Analysis., PMID:39813003

Emerging oral therapeutic strategies for inhibiting PCSK9., PMID:39802651

PCSK9 Inhibitors: Focus on Evolocumab and Its Impact on Atherosclerosis Progression., PMID:39770423

Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897

Datasheet

Document Download

Research Grade Alirocumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Alirocumab [DHJ24001]
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