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Research Grade Siltuximab

Catalog #:   DHC15801 Specific References (98) DATASHEET
Host species: Chimeric
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC15801

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05231

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CLLB8, CNTO 328, CAS: 541502-14-1

Clone ID

Siltuximab

Data Image
  • Bioactivity
    Detects Human IL6 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Siltuximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial, PMID: 25042199

Siltuximab, PMID: 31644237

Siltuximab, PMID: 29999789

Pharmaco-Immunomodulatory Therapy in COVID-19, PMID: 32696108

Long-term safety of siltuximab in patients with idiopathic multicentric Castleman disease: a prespecified, open-label, extension analysis of two trials, PMID: 32027862

Involvement of interleukin 6 in SARS-CoV-2 infection: siltuximab as a therapeutic option against COVID-19, PMID: 32499314

Impact of siltuximab on patient-related outcomes in multicentric Castleman's disease, PMID: 29391839

Siltuximab: A Review in Idiopathic (Human Herpesvirus-8-Negative) Multicentric Castleman Disease, PMID: 26394632

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy, PMID: 27049586

Clinical development of siltuximab, PMID: 25986720

Siltuximab and hematologic malignancies. A focus in non Hodgkin lymphoma, PMID: 28140696

Cytokine storm intervention in the early stages of COVID-19 pneumonia, PMID: 32360420

Siltuximab: first global approval, PMID: 24958337

CAR T-Cells, PMID: 32301017

Siltuximab: a new option for the management of Castleman's disease, PMID: 25685858

Siltuximab (CNTO 328): a promising option for human malignancies, PMID: 26170629

Siltuximab (Sylvant) for treatment of multicentric castleman's disease, PMID: 25555075

Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease, PMID: 26634298

FDA approval: siltuximab for the treatment of patients with multicentric Castleman disease, PMID: 25601959

Population pharmacokinetics of siltuximab: impact of disease state, PMID: 31482226

Review of siltuximab in the treatment of multicentric Castleman's disease, PMID: 27904739

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study, PMID: 32593339

Frontline Siltuximab and Rituximab in TAFRO syndrome: A case report, PMID: 32564425

The clinical, laboratory, and radiologic improvement due to siltuximab treatment in idiopathic multicentric Castleman's disease, PMID: 32088937

Treatment of Idiopathic Castleman Disease, PMID: 29157622

Interleukin-6 as a therapeutic target, PMID: 25589616

Siltuximab (Sylvant). Castleman's disease: good symptomatic efficacy in some patients, PMID: 27152394

Siltuximab in relapsed/refractory multicentric Castleman disease: Experience of the Italian NPP program, PMID: 30074630

Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Siltuximab in High-Risk Smoldering Multiple Myeloma, PMID: 30890552

Interleukin-6: A Masterplayer in the Cytokine Network, PMID: 31958792

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review, PMID: 33068263

Emerging agents and regimens for multiple myeloma, PMID: 33168044

Targeting interleukin-6 in inflammatory autoimmune diseases and cancers, PMID: 24076269

Targeting interleukin 6 signaling by monoclonal antibody siltuximab on cholangiocarcinoma, PMID: 33091158

International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease, PMID: 30181172

Diagnosis and Management of Castleman Disease, PMID: 31766018

Dose selection of siltuximab for multicentric Castleman's disease, PMID: 25784388

Emerging treatments in Castleman disease - a critical appraisal of siltuximab, PMID: 26869762

Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease, PMID: 30487129

Role of monoclonal antibody drugs in the treatment of COVID-19, PMID: 33083387

Newly diagnosed and previously treated multicentric Castleman disease respond equally to siltuximab, PMID: 33128769

Siltuximab for multicentric Castleman disease, PMID: 25110138

Renal Toxicities of Novel Agents Used for Treatment of Multiple Myeloma, PMID: 27654928

[Effects of siltuximab on the interleukin-6/Stat3 signaling pathway in ovarian cancer], PMID: 21211286

The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer, PMID: 30372844

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors), PMID: 29447987

Effect of siltuximab, omalizumab, infliximab, pembrolizumab and vedolizumab on selected haematological and biochemical parameters in a pig model, PMID: 32233286

Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities, PMID: 28707587

Interleukin-6 inhibition in the management of non-infectious uveitis and beyond, PMID: 31523783

Siltuximab in transplant-ineligible patients with myeloma, PMID: 25121174

Management strategies for CAR-T cell therapy-related toxicities: results from a survey in Greece., PMID:40520784

[Sequential treatment with siltuximab and tocilizumab for childhood idiopathic multicentric Castleman disease: a case report]., PMID:40462437

Expert Perspective: Diagnosis and Treatment of Castleman Disease., PMID:40457814

[Siltuximab as a salvage therapy in multi-refractory adult-onset Still's disease: A case series]., PMID:40413088

Case Report: Successful use of emapalumab in adult B-cell acute lymphoblastic leukemia experiencing severe neurotoxicity and hemophagocytic lymphohistiocytosis-like features after CAR-T cell therapy., PMID:40255392

LRG1, a novel serum biomarker for iMCD disease activity., PMID:40197491

Siltuximab for the treatment of early complications after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia in children, adolescents, and young adults., PMID:40176077

Real-world data of siltuximab for Chinese patients with iMCD: combination with BCD regimen as a potential approach for severe cases., PMID:40175604

Spontaneous remission of iMCD-TAFRO: a case report., PMID:40137982

Idiopathic Multicentric Castleman's Disease Presenting with Chorioretinal Undulation: A Case Report., PMID:40101154

Inhibition of inflammation by IL-6 blockade in xenotransplantation., PMID:39999679

Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy., PMID:39893129

Pericytes Promote More Vascularization than Stromal Cells via an Interleukin-6-Dependent Mechanism in Microfluidic Chips., PMID:39887579

Osteosarcoma biomarker analysis and drug targeting prediction based on pyroptosis-related genes., PMID:39833053

Multicentric Castleman's Disease presenting with bilateral panuveitis., PMID:39819875

The Value of a Pet Scan in Selecting the Best Lymph Node to Biopsy, and Confirming the Diagnosis of Idiopathic Multicentric Castleman Disease with HLH And EBV Viremia in a Previously Healthy Adult., PMID:39651386

The Enigma of Idiopathic Multicentric Castleman Disease: An Elusive Diagnosis., PMID:39650978

Cytokine testing and challenges for diagnostic and clinical monitoring use., PMID:39613111

Rapid Relapse of Idiopathic Multicentric Castleman Disease After Siltuximab Discontinuation in a Case with Complete Remission for More Than 10 Years., PMID:39501708

Siltuximab in Idiopathic Multicentric Castleman Disease: Real-World Experience., PMID:39493599

Siltuximab for chimeric antigen receptor T-cell therapy-related CRS and ICANS: a multicenter retrospective analysis., PMID:39437770

Novel use of Siltuximab in a patient with VEXAS Syndrome., PMID:39417832

Cytokine Release Syndrome Associated With Immune-Modulating Chemotherapy: Potential Mitigating Role of Intravenous Omega-3 Fatty Acid Triglycerides., PMID:39376028

Diagnostic challenges in patients with Castleman disease, a single center experience from Hungary., PMID:39252787

Unraveling the Complexities of Idiopathic Multicentric Castleman Disease and Its Multi-systemic Associations: A Case Report., PMID:39161530

IL-6 Blockade in Cytokine Storm Syndromes., PMID:39117839

Identification of critical genes and metabolic pathways in rheumatoid arthritis and osteoporosis toward drug repurposing., PMID:39079412

Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report., PMID:39044832

TAFRO Syndrome: Guidance for Managing Patients Presenting Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly., PMID:38927484

Corrigendum: Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences., PMID:38899278

Efficacy and Safety of Sintilimab Combined with Pemetrexed and Platinum Chemotherapy in Non-Small Cell Lung Cancer Patients., PMID:38870510

Idiopathic multicentric Castleman disease and connective tissue disorder successfully treated by siltuximab: a pediatric case report., PMID:38840677

Efficacy of Siltuximab and 1,927 nm Fractional Laser for the Treatment of Cutaneous Manifestations in Castleman's Disease: The Role of Dermoscopy and Reflectance Confocal Microscopy for Lesion Evaluation., PMID:38590388

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences., PMID:38510313

A case report: Castleman disease treated by the trinity of internal and external treatment of "Fuzheng, phlegm-resolving, and detoxification method"., PMID:38306555

Text Mining and Drug Discovery Analysis: A Comprehensive Approach to Investigate Diabetes-Induced Osteoporosis., PMID:38250601

Therapy of Castleman's disease with siltuximab - case report and review of literature., PMID:38195387

Castleman's disease: one disease, multiple etiologies., PMID:39970477

Lymphadenopathy in the rheumatology practice: a pragmatic approach., PMID:38109670

Idiopathic multicentric Castleman disease: An update in diagnosis and treatment advances., PMID:38087716

Expression Analysis of Long Noncoding RNA-MALAT1 and Interleukin-6 in Inflammatory Bowel Disease Patients., PMID:38085149

Long-Term Tolerance and Efficacy of Siltuximab (Anti-IL-6) in a Young Adult with Idiopathic Multicentric Castleman Disease During COVID-19., PMID:38077710

Stepwise Treatment for TAFRO Syndrome., PMID:38029058

Castleman's disease, pathophysiology, advances in diagnosis and treatment., PMID:38016855

Siltuximab administration results in spurious IL-6 elevation in peripheral blood., PMID:37867418

A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report., PMID:37854256

Molecular and Clinical Characteristics of Different Toxicity Rates in Anti-CD19 Chimeric Antigen Receptor T Cells: Real-World Experience., PMID:37686529

Treatment consistent with idiopathic multicentric Castleman disease guidelines is associated with improved outcomes., PMID:37656441

Datasheet

Document Download

Research Grade Siltuximab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Siltuximab [DHC15801]
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