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Research Grade Ramucirumab

Catalog #:   DHE16601 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHE16601

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

FLK-1, Kinase insert domain receptor, VEGFR2, Fetal liver kinase 1, CD309, Vascular endothelial growth factor receptor 2, Protein-tyrosine kinase receptor flk-1, FLK1, VEGFR-2, KDR

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P35968

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

1121B, IMC-1121B, LY3009806, CAS: 947687-13-0

Clone ID

Ramucirumab

Data Image
  • Bioactivity
    Detects Human CD309/KDR/VEGFR-2 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Ramucirumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial, PMID: 25240821

Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial, PMID: 31591063

Ramucirumab for the treatment of gastric or gastro-esophageal junction cancer, PMID: 31452409

Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial, PMID: 24933332

Ramucirumab: A Review in Hepatocellular Carcinoma, PMID: 32034692

Ramucirumab, PMID: 27340327

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial, PMID: 30665869

Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study, PMID: 25877855

Ramucirumab, PMID: 31643324

Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial, PMID: 24094768

Ramucirumab and its use in the treatment of hepatocellular carcinoma, PMID: 30644314

Ramucirumab, PMID: 29999742

The safety of ramucirumab for the treatment of colorectal cancer, PMID: 30073902

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial, PMID: 31753727

Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial, PMID: 26095784

Ramucirumab and durvalumab for previously treated, advanced non-small-cell lung cancer, gastric/gastro-oesophageal junction adenocarcinoma, or hepatocellular carcinoma: An open-label, phase Ia/b study (JVDJ), PMID: 32827847

Ramucirumab or placebo plus erlotinib in EGFR-mutated, metastatic non-small-cell lung cancer: East Asian subset of RELAY, PMID: 32954593

Ramucirumab, A Second-Line Option For Patients With Hepatocellular Carcinoma: A Review Of The Evidence, PMID: 32547208

Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial, PMID: 30718072

Ramucirumab: the long and winding road toward being an option for mCRC treatment, PMID: 30917706

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial, PMID: 28916371

Ramucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open-Label, Phase I Trial (JVDF), PMID: 29853658

Ramucirumab plus pembrolizumab in patients with previously treated advanced non-small-cell lung cancer, gastro-oesophageal cancer, or urothelial carcinomas (JVDF): a multicohort, non-randomised, open-label, phase 1a/b trial, PMID: 31301962

Ramucirumab: Boon or bane, PMID: 27025409

[Ramucirumab - a new anticancer agent], PMID: 27690622

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 + T cells in the tumor microenvironment, PMID: 30314524

Molecular therapies and precision medicine for hepatocellular carcinoma, PMID: 30061739

Gastric cancer, PMID: 27156933

A phase II study of nab-paclitaxel in combination with ramucirumab in patients with previously treated advanced gastric cancer, PMID: 29353164

Nephrotic syndrome associated with ramucirumab therapy: A single-center case series and literature review, PMID: 31277139

Ramucirumab combined with FOLFOX as front-line therapy for advanced esophageal, gastroesophageal junction, or gastric adenocarcinoma: a randomized, double-blind, multicenter Phase II trial, PMID: 27765757

Ramucirumab for gastric cancer, PMID: 25431958

Ramucirumab: first global approval, PMID: 24916147

Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer, PMID: 32719002

Ramucirumab: A Review in Advanced Gastric Cancer, PMID: 26341713

Ramucirumab as a second line therapy for advanced HCC: a significant achievement or a wasted opportunity for personalised therapy?, PMID: 30879152

The Impact of Ramucirumab Treatment on Survival and Quality of Life in Patients with Gastric Cancer, PMID: 32021422

Ramucirumab in the treatment of non-small cell lung cancer, PMID: 28395526

Ramucirumab: A vascular endothelial growth factor receptor-2 inhibitor with activity in several malignancies, PMID: 27217518

Ramucirumab: successfully targeting angiogenesis in gastric cancer, PMID: 25281695

Potential of ramucirumab in treating hepatocellular carcinoma patients with elevated baseline alpha-fetoprotein, PMID: 30464931

Osimertinib plus Ramucirumab: The Best of Both Worlds?, PMID: 33334907

A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy, PMID: 27565938

Ramucirumab Clinical Development: an Emerging Role in Gastrointestinal Tumors, PMID: 26887374

Biomarker analysis beyond angiogenesis: RAS/RAF mutation status, tumour sidedness, and second-line ramucirumab efficacy in patients with metastatic colorectal carcinoma from RAISE-a global phase III study, PMID: 30339194

Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2, PMID: 32279446

Ramucirumab for the treatment of advanced or metastatic non-small cell lung cancer, PMID: 27737562

Ramucirumab: targeting angiogenesis in the treatment of gastric cancer, PMID: 25496333

Current status of ramucirumab in gastroesophageal adenocarcinoma, PMID: 28436242

Ramucirumab for advanced gastric cancer or gastro-oesophageal junction adenocarcinoma, PMID: 26557893

Treatments and Outcomes After Platinum-Based Chemotherapy and Anti-PD-(L)1 in NSCLC., PMID:40526385

Advances in Molecular Imaging of VEGFRs: Innovations in Imaging and Therapeutics., PMID:40508182

"Attenuated" Pulmonary Tumor Thrombotic Microangiopathy on Anti-Vascular Endothelial Growth Factor Treatment: A Case Report., PMID:40475293

Association Between Baseline Neutrophil Count and Febrile Neutropenia Following Docetaxel and Ramucirumab With Prophylactic Pegfilgrastim., PMID:40468685

Final Survival Outcomes With Ramucirumab Plus Erlotinib Versus Placebo Plus Erlotinib in Patients With Untreated EGFR-Mutated Metastatic NSCLC: RELAY Japanese Subset., PMID:40458541

Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer., PMID:40454632

EXPRESS: Advanced Therapies for Stomach Cancer., PMID:40448345

Randomized Phase III Trial of Ramucirumab Beyond Progression Plus Irinotecan in Patients With Ramucirumab-Refractory Advanced Gastric Cancer: RINDBeRG Trial., PMID:40408613

Comparison of dose rounding and drug vial optimization for reducing anticancer drug waste., PMID:40398488

Enhancing hepatocellular carcinoma treatment: synergistic cytotoxicity and mechanistic insights of Ramucirumab and 5-Azacytidine combination therapy., PMID:40397219

Real-world treatment and outcomes for EGFR WT advanced/metastatic non-squamous non-small cell lung cancer: pooled analysis from project LUMINATE-101., PMID:40338221

Therapeutic management of patients with advanced thymic malignancies: A review for clinicians., PMID:40334289

Maintenance Capecitabine Plus Ramucirumab After First-Line Chemotherapy in Patients With Advanced Esophagogastric Adenocarcinoma: Results From the Randomized PLATFORM Study., PMID:40330143

Unravelling Paclitaxel Resistance in Gastric Cancer: The Role of Small Extracellular Vesicles in Epithelial Mesenchymal Transition and Extracellular Matrix Remodelling., PMID:40282535

Thromboembolic and bleeding events associated with angiogenesis inhibitors in cancer patients., PMID:40246589

A disproportionality analysis of interstitial lung disease associated with drug therapy in spontaneous adverse event reports., PMID:40232264

Toxicity Profile and Efficacy of Docetaxel Following Paclitaxel- or Pemetrexed-Platinum Chemotherapy Alone or in Combination With Immune Checkpoint Inhibitors in NSCLC Patients: A Single Institution Retrospective Analysis., PMID:40220012

[A Case of Long-Term Prognosis of Advanced Rectosigmoid Cancer with Multiple Metastases Treated with Multidisciplinary Therapy]., PMID:40189763

S2303: phase II/III trial of paclitaxel + ramucirumab ± nivolumab in gastric and esophageal adenocarcinoma (PARAMUNE)., PMID:40155326

Ramucirumab and paclitaxel in second or greater lines of therapy in patients with HER2-positive gastroesophageal cancer: a single center study., PMID:40152313

Pairwise analysis of plasma cell-free DNA before and after palliative second-line paclitaxel plus ramucirumab treatment in patients with metastatic gastric cancer., PMID:40148708

Comparison of the prognostic effect of taxane regimens combined with ramucirumab before nivolumab for advanced gastric cancer., PMID:40095335

Successful Desensitization to Ramucirumab in Signet-Cell Gastric Adenocarcinoma., PMID:40079904

Nab-paclitaxel combined with cadonilimab (AK104) as second-line treatment for advanced gastric cancer: protocol for a phase II prospective, multicenter, single-arm clinical trial., PMID:40070819

Correction: Clinical Significance of Prior Ramucirumab Use on the Effectiveness of Nivolumab as the Third-Line Regimen in Gastric Cancer: A Multicenter Retrospective Study., PMID:40067648

Complete Remission with Nivolumab Monotherapy of Advanced Gastric Neuroendocrine Carcinoma., PMID:40024686

Drug-Induced Chylothorax During Chemotherapy With Ramucirumab and Paclitaxel for Advanced Gastric Cancer., PMID:39991332

In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss., PMID:39979532

[A Case of Multiple Brain Metastasis after Resection of Gastric Cancer with Adrenal Metastasis]., PMID:39948918

Monoclonal Antibodies and Small-Molecule Inhibitors Associated Osteonecrosis of Jaw: A Retrospective Pharmacovigilance Study., PMID:39922223

Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment including fluoropyrimidine, platinum, and anti-PD-1/PD-L1 antibody (PADDLE)., PMID:39905373

A Case of Purpuric Papulopustular Eruption on the Extremities Developed During Erlotinib and Ramucirumab Combination Treatment, Resulting in Complete Regression Without Oral Prednisone or Discontinuing Chemotherapy., PMID:39881923

Efficacy of ramucirumab combined with erlotinib or osimertinib in untreated EGFR-mutated NSCLC patients with asymptomatic brain metastases: insights from molecular biomarkers in the RELAY-brain trial., PMID:39847172

A phase II study of ramucirumab and somatostatin analog therapy in patients with advanced neuroendocrine tumors., PMID:39834129

A non-interventional biomarker study in patients with adenocarcinoma of the lung treated with nintedanib plus docetaxel following progression on chemotherapy and/or immunotherapy: LUME-BioNIS., PMID:39830745

Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials., PMID:39805409

The Efficacy of FOLFIRI Plus Ramucirumab in Recurrent Colorectal Cancer Refractory to Adjuvant Chemotherapy with Oxaliplatin/Fluoropyrimidine-Including Biomarker Analyses., PMID:39796720

Immune Microenvironment and the Effect of Vascular Endothelial Growth Factor Inhibition in Hepatocellular Carcinoma., PMID:39769351

Circulating miR-23b-3p, miR-30e-3p, and miR-205-5p as Novel Predictive Biomarkers for Ramucirumab-Paclitaxel Therapy Outcomes in Advanced Gastric Cancer., PMID:39769259

Addressing the unmet need in NSCLC progression with advances in second-line therapeutics., PMID:39759220

[A Case of Pathological Complete Response after Nivolumab Therapy in Unresectable Advanced Gastric Cancer]., PMID:39721791

Alternating Administration of Osimertinib for Leptomeningitis and Docetaxel Plus Ramucirumab for Lung Adenocarcinoma Resistant to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Case Report., PMID:39721695

What is the optimal first-line regimen for advanced non-small cell lung cancer patients with epidermal growth factor receptor mutation: a systematic review and network meta-analysis., PMID:39695621

A real-world disproportionality analysis of FDA Adverse Event Reporting System (FAERS) events for ramucirumab., PMID:39656165

Advances in systemic therapy leading to conversion surgery for advanced hepatocellular carcinoma., PMID:39647858

Impact of ABCB1 single-nucleotide variants on early, extremely severe neutropenia induced by paclitaxel/nanoparticle albumin-bound paclitaxel in patients with gastric cancer., PMID:39622587

RELAY: Final Overall Survival for Erlotinib Plus Ramucirumab or Placebo in Untreated, EGFR-Mutated Metastatic NSCLC., PMID:39622410

S1701, A Randomized Phase 2 Trial of Carboplatin-Paclitaxel With and Without Ramucirumab in Patients With Locally Advanced, Recurrent, or Metastatic Thymic Carcinoma., PMID:39619274

A case of complete remission by cabozantinib as an end-line treatment for advanced hepatocellular carcinoma., PMID:39616585

Clinicopathological analysis of claudin 18.2 focusing on intratumoral heterogeneity and survival in patients with metastatic or unresectable gastric cancer., PMID:39615405

Datasheet

Document Download

Research Grade Ramucirumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Ramucirumab [DHE16601]
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