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Research Grade Raxibacumab

Catalog #:   DXX00402 Specific References (76) DATASHEET
Host species: Human
Isotype: IgG1-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DXX00402

Expression system

Mammalian Cells

Species reactivity

Bacillus anthracis

Host species

Human

Isotype

IgG1-lambda

Clonality

Monoclonal

Target

Protective antigen, PA, Anthrax toxins translocating protein, PA-83, PA83, Protective antigen PA-20, PA-20, PA20, Protective antigen PA-63, PA-63, PA63, pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P13423

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 565451-13-0

Clone ID

Raxibacumab

Data Image
  • SDS-PAGE
    SDS PAGE for Raxibacumab
References

Raxibacumab, PMID: 20068396

Raxibacumab: a panacea for anthrax disease?, PMID: 32333846

Raxibacumab for anthrax, PMID: 23545582

Raxibacumab: potential role in the treatment of inhalational anthrax, PMID: 24812521

Raxibacumab, PMID: 33886175

Effect of raxibacumab on immunogenicity of Anthrax Vaccine Adsorbed: a phase 4, open-label, parallel-group, randomised non-inferiority study, PMID: 32333847

Raxibacumab for the treatment of inhalational anthrax, PMID: 19587338

Raxibacumab for inhalational anthrax: an effective specific therapeutic approach?, PMID: 20450444

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines, PMID: 26097803

Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax, PMID: 25487792

Approval of Raxibacumab for the Treatment of Inhalation Anthrax Under the US Food and Drug Administration "Animal Rule", PMID: 26648915

Population pharmacokinetics of raxibacumab in healthy adult subjects, PMID: 33973655

Pharmacology and Anti-infective Role of Raxibacumab: A Novel Monoclonal Antibody for the Treatment of Anthrax, PMID: 28358441

Teriflunomide, PMID: 24421467

Extrapolation and dosing recommendations for raxibacumab in children from birth to age <18 years, PMID: 33974281

Anthrax Antitoxins, PMID: 31644058

Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits, PMID: 23344456

Estimation of Time Period for Effective Human Inhalational Anthrax Treatment Including Antitoxin Therapy, PMID: 28856066

Obiltoxaximab (Anthim) for inhalation anthrax, PMID: 30383733

Bacillus anthracis infections--new possibilities of treatment, PMID: 26094508

Designing inhibitors of anthrax toxin, PMID: 24447197

Pharmaceutical approval update, PMID: 23599674

Development trends for human monoclonal antibody therapeutics, PMID: 20811384

A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for B. anthracis infection: A need for more robust study designs and results, PMID: 28797061

Monoclonal Antibodies Against Infectious Microbes: So Long and Too Little!, PMID: 32164518

Antitoxin Treatment of Inhalation Anthrax: A Systematic Review, PMID: 26690378

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models, PMID: 33450877

Alternative pre-approved and novel therapies for the treatment of anthrax, PMID: 27809794

Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model, PMID: 28438974

Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax, PMID: 26426050

Pediatric anthrax clinical management: executive summary, PMID: 24777221

Protecting against future shock--inhalational anthrax, PMID: 19587345

Animal rule for drug approval creates a jungle of confusion, PMID: 23389593

Special considerations for prophylaxis for and treatment of anthrax in pregnant and postpartum women, PMID: 24457117

Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults, PMID: 24447897

New drugs 2014, part 2, PMID: 24905857

United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism., PMID:37594915

Survival of Patient With Hemorrhagic Meningitis Associated With Inhalation Anthrax., PMID:36251557

Pre- and Postlicensure Animal Efficacy Studies Comparing Anthrax Antitoxins., PMID:36251555

A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis., PMID:35369443

Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives., PMID:35099182

Monoclonal Antibodies for Protozoan Infections: A Future Reality or a Utopic Idea?, PMID:34712683

Extrapolation and dosing recommendations for raxibacumab in children from birth to age <18 years., PMID:33974281

Population pharmacokinetics of raxibacumab in healthy adult subjects., PMID:33973655

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models., PMID:33450877

Effect of raxibacumab on immunogenicity of Anthrax Vaccine Adsorbed: a phase 4, open-label, parallel-group, randomised non-inferiority study., PMID:32333847

Raxibacumab: a panacea for anthrax disease?, PMID:32333846

Monoclonal Antibodies Against Infectious Microbes: So Long and Too Little!, PMID:32164518

Obiltoxaximab (Anthim) for inhalation anthrax., PMID:30383733

Estimation of Time Period for Effective Human Inhalational Anthrax Treatment Including Antitoxin Therapy., PMID:28856066

A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for B. anthracis infection: A need for more robust study designs and results., PMID:28797061

Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model., PMID:28438974

Alternative pre-approved and novel therapies for the treatment of anthrax., PMID:27809794

Pharmacology and Anti-infective Role of Raxibacumab: A Novel Monoclonal Antibody for the Treatment of Anthrax., PMID:28358441

Antitoxin Treatment of Inhalation Anthrax: A Systematic Review., PMID:26690378

Approval of Raxibacumab for the Treatment of Inhalation Anthrax Under the US Food and Drug Administration "Animal Rule"., PMID:26648915

Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax., PMID:26426050

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines., PMID:26097803

Bacillus anthracis infections--new possibilities of treatment., PMID:26094508

Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax., PMID:25487792

New drugs 2014, part 2., PMID:24905857

Raxibacumab: potential role in the treatment of inhalational anthrax., PMID:24812521

Pediatric anthrax clinical management: executive summary., PMID:24777221

Special considerations for prophylaxis for and treatment of anthrax in pregnant and postpartum women., PMID:24457117

Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults., PMID:24447897

Designing inhibitors of anthrax toxin., PMID:24447197

Teriflunomide., PMID:24421467

Pharmaceutical approval update., PMID:23599674

Raxibacumab for anthrax., PMID:23545582

Animal rule for drug approval creates a jungle of confusion., PMID:23389593

Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits., PMID:23344456

Development trends for human monoclonal antibody therapeutics., PMID:20811384

Raxibacumab for inhalational anthrax: an effective specific therapeutic approach?, PMID:20450444

Raxibacumab., PMID:20068396

Protecting against future shock--inhalational anthrax., PMID:19587345

Raxibacumab for the treatment of inhalational anthrax., PMID:19587338

Datasheet

Document Download

Research Grade Raxibacumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Raxibacumab [DXX00402]
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