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Research Grade Denosumab

Catalog #:   DHA30301 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG2-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHA30301

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

ODF, TNF-related activation-induced cytokine, Osteoclast differentiation factor, TNFSF11, TRANCE, Osteoprotegerin ligand, RANKL, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa-B ligand, CD254, OPGL

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O14788

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG162, CAS: 615258-40-7

Clone ID

Denosumab

Data Image
  • SDS-PAGE
    SDS PAGE for Denosumab
References

Stopping Denosumab, PMID: 30659428

Denosumab: A Review in Postmenopausal Osteoporosis, PMID: 29435849

Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS, PMID: 28789921

A Review on the Role of Denosumab in Fracture Prevention, PMID: 33061307

10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension, PMID: 28546097

Denosumab: Prevention and management of hypocalcemia, osteonecrosis of the jaw and atypical fractures, PMID: 27862983

Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials, PMID: 25639776

Bone Mineral Density After Transitioning From Denosumab to Alendronate, PMID: 31665314

Denosumab: a new agent in the management of hypercalcemia of malignancy, PMID: 26403973

Effects and management of denosumab discontinuation, PMID: 29317292

Denosumab: AHFS 92:24, PMID: 29864491

Denosumab compared to bisphosphonates to treat postmenopausal osteoporosis: a meta-analysis, PMID: 30071889

Denosumab for dialysis patients with osteoporosis: A cohort study, PMID: 32051451

Comparison of Denosumab and Bisphosphonates in Patients With Osteoporosis: A Meta-Analysis of Randomized Controlled Trials, PMID: 30535289

Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis : A Population-Based Cohort Study, PMID: 32716706

Denosumab cessation, PMID: 32487553

Denosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis, PMID: 31616133

Drug holidays from bisphosphonates and denosumab in postmenopausal osteoporosis: EMAS position statement, PMID: 28539165

Denosumab in the treatment of glucocorticoid-induced osteoporosis, PMID: 30019224

Denosumab and cinacalcet for primary hyperparathyroidism (DENOCINA): a randomised, double-blind, placebo-controlled, phase 3 trial, PMID: 32333877

Treatment with Zoledronate Subsequent to Denosumab in Osteoporosis: a Randomized Trial, PMID: 32459005

Denosumab for the treatment of bone disease in solid tumors and multiple myeloma, PMID: 29052442

Denosumab treatment for giant-cell tumor of bone: a systematic review of the literature, PMID: 30877429

Efficacy and safety of denosumab vs. bisphosphonates in postmenopausal women previously treated with oral bisphosphonates, PMID: 31776637

Denosumab or romosozumab therapy and risk of cardiovascular events in patients with primary osteoporosis: Systematic review and meta- analysis, PMID: 31678488

Effects of Long-Term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis, PMID: 29672714

A comprehensive review of denosumab for bone metastasis in patients with solid tumors, PMID: 26451465

Denosumab versus risedronate in glucocorticoid-induced osteoporosis: a multicentre, randomised, double-blind, active-controlled, double-dummy, non-inferiority study, PMID: 29631782

Off-label uses of denosumab in metabolic bone diseases, PMID: 31454537

Romosozumab followed by denosumab in Japanese women with high fracture risk in the FRAME trial, PMID: 33057807

One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study, PMID: 30508316

Denosumab in osteoporosis, PMID: 24289327

Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study, PMID: 29694685

FRAME Study: The Foundation Effect of Building Bone With 1 Year of Romosozumab Leads to Continued Lower Fracture Risk After Transition to Denosumab, PMID: 29573473

Risk for Infections During Treatment With Denosumab for Osteoporosis: A Systematic Review and Meta-analysis, PMID: 31899506

Denosumab is not associated with risk of malignancy: systematic review and meta-analysis of randomized controlled trials, PMID: 33145606

Denosumab for Reducing Risk of Fractures in Postmenopausal Women, PMID: 31038897

Effects of Denosumab and Alendronate on Bone Health and Vascular Function in Hemodialysis Patients: A Randomized, Controlled Trial, PMID: 30690785

Efficacy and safety of denosumab compared to bisphosphonates in improving bone strength in postmenopausal osteoporosis: a systematic review, PMID: 30854568

Certainties and Uncertainties About Denosumab Discontinuation, PMID: 29926143

Radiological findings of denosumab treatment for giant cell tumours of bone, PMID: 32335707

Comparative Safety and Effectiveness of Denosumab Versus Zoledronic Acid in Patients With Osteoporosis: A Cohort Study, PMID: 27736041

Denosumab Versus Zoledronic Acid in Bone Disease Treatment of Newly Diagnosed Multiple Myeloma: An International, Double-Blind, Randomized Controlled Phase 3 Study-Asian Subgroup Analysis, PMID: 32524500

Hypocalcaemia following denosumab in prostate cancer: A clinical review, PMID: 32017154

Effects of Denosumab After Treatment Discontinuation : A Review of the Literature, PMID: 29720299

Denosumab in Prevention of Implant Migration, PMID: 32609393

Adjuvant denosumab in early breast-cancer, PMID: 32135108

Adjuvant denosumab in early breast-cancer, PMID: 32135107

Aneurysmal bone cyst: results of an off label treatment with Denosumab, PMID: 31630689

Denosumab: A Unique Perspective on Adherence and Cost-effectiveness Compared With Oral Bisphosphonates in Osteoporosis Patients, PMID: 29616561

Medication-Related Osteonecrosis of the Jaws in Patients on Antiresorptive Medication With Dental Implants. A Scoping Review., PMID:40531168

Improving High-Risk Osteoporosis Medication Adherence and Safety With an Automated Dashboard., PMID:40529844

Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach., PMID:40529292

Refractory Denosumab-induced Hypocalcemia in a High-risk Patient With Osteoblastic Metastatic Prostate Adenocarcinoma., PMID:40520041

Postoperative Denosumab Therapy in Aneurysmal Bone Cysts and Osteoblastomas: A Case Series and Review of Current Literature., PMID:40519436

Atypical Femoral Fracture in Patients With Metastatic Bone Tumors: An Analysis Based on the Japanese Adverse Drug Event Reaction Database (JADER)., PMID:40519387

Osteoporosis Management after the Occurrence of Medication-Related Osteonecrosis of the Jaw: A 13-Year Experience at a Tertiary Center., PMID:40509705

Denosumab-bbdz: A Review of the Interchangeable Biosimilar for the Treatment of Osteoporosis., PMID:40509651

RANKL Drives Bone Metastasis in Mammary Cancer: Protective Effects of Anti-Resorptive Treatments., PMID:40507804

Bisphosphonate beak without the bisphosphonate: atypical femoral fracture with denosumab., PMID:40506101

Dental implant failure and medication-related osteonecrosis of the jaw (MRONJ) related to dental implants in patients taking antiresorptive therapy for osteoporosis: a systematic review and meta-analysis., PMID:40505730

Patterns of adjuvant bone modifying agent use in patients with early-stage breast cancer in the United States., PMID:40500761

Prolonged hypercalcemia induced by teriparatide: a case report and literature review., PMID:40500389

Delayed-onset hypocalcaemia and hypophosphataemia induced by iron infusion in the context of denosumab therapy., PMID:40499946

Severe immunotherapy-related thrombocytopenia in metastatic bone cancer: a multicenter retrospective case series highlighting early recognition and management., PMID:40496609

Denosumab in patients with osteogenesis imperfecta and a historical control study with alendronate., PMID:40496553

The prevention of osteoporotic vertebral fractures in eastern and in western countries., PMID:40495909

Fragility of Evidence for the Efficacy of Anti-fracture Medications., PMID:40488289

Moderate-to-severe hypercalcemia secondary to primary hyperparathyroidism refractory to conventional treatment (therapeutic management with denosumab): case report and literature review., PMID:40486005

30 YEARS OF BONE GIANT CELL TUMOR IN THE KNEE: A BRAZILIAN PERSPECTIVE., PMID:40475359

Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis., PMID:40469971

Diagnosis of skeletal fragility due to Loeys-Dietz syndrome and treatment with romosozumab followed by denosumab., PMID:40469084

Primary Hyperparathyroidism with Severe Vitamin D Deficiency in Chronic Kidney Disease., PMID:40467506

Asia-Pacific consensus for the management of osteoporosis in men., PMID:40464984

Novel approach to central giant cell granuloma of the Jaw: Low-dose intralesional denosumab treatment in a case series of nine patients., PMID:40461338

Impact of denosumab on muscle health in older adults in long-term care., PMID:40460961

Enzalutamide plus radium-223 in metastatic castration-resistant prostate cancer: results of the EORTC 1333/PEACE-3 trial., PMID:40450503

Atypical femoral fracture associated with sequential zoledronic acid and denosumab therapy: a case report., PMID:40459674

A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget's disease of bone., PMID:40458045

Treatment of Osteoporosis in Patients with Chronic Kidney Disease., PMID:40457078

The link between osteoporosis and cardiovascular diseases: a review of shared mechanisms, risk factors, and therapeutic approaches., PMID:40455217

Long-term effectiveness and safety of denosumab for osteoporosis in patients with rheumatic diseases., PMID:40451270

Use of Low-Value Cancer Treatments in Medicare Advantage Versus Traditional Medicare., PMID:40448575

Characteristics and treatment options of 272,152 geriatric patients with very high and high fracture risk., PMID:40445411

Comparison of Type 2 Diabetes Risk in Osteoporosis Patients Treated with Denosumab or Alendronate: A Nationwide Cohort Study., PMID:40445395

EXPRESS: Osteoblasts inhibit NK cell killing function via RANK/RANKL in multiple myeloma., PMID:40444878

A practical use of bone turnover markers in management of patients with skeletal fragility., PMID:40439877

Understanding and Managing Fracture Risk in Patients With Cancer: A Literature Review., PMID:40438830

Five-Year Sales Trends of Osteoporosis Medications in Korea: A Market Analysis Based on IMS Health Sales Audit Data (2018-2023)., PMID:40428763

Supra-Physiological Levels of Magnesium Counteract the Inhibitory Effect of Zoledronate on RANKL-Dependent Osteoclastogenesis., PMID:40427722

Comprehensive Evaluation of Treatment Patterns in Postmenopausal Patients with Osteoporosis without Fractures: Insights from Tertiary Care Institutions and Nationwide OMOP-CDM Data., PMID:40426310

Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling., PMID:40425548

Comparative analysis of Denosumab and Zoledronic acid in advanced breast cancer patients receiving CDK4/6 inhibitors., PMID:40424680

Denosumab and Fracture Prevention in Primary Care Practice., PMID:40423959

Symptomatic hypocalcaemia after administration of denosumab and iron infusion in patients with normal and impaired renal function., PMID:40423532

Role of denosumab in lipid metabolism disorders: clinical significance and potential mechanisms., PMID:40418391

No overshoot of bone turnover after withdrawal of denosumab treatment of adults with Langerhans cell histiocytosis: a prospective clinical trial., PMID:40418338

Evaluation of Anti-SARS-CoV-2 IgG Responses in a Clinical Study of a Biosimilar Candidate to Denosumab Using Singlicate Analysis., PMID:40408051

Effect of denosumab on semen quality in infertile men selected by serum level of antimüllerian hormone: a randomized controlled trial., PMID:40403914

Denosumab treatment of giant cell tumors in the spine induces woven bone formation., PMID:40390810

Datasheet

Document Download

Research Grade Denosumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Denosumab [DHA30301]
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