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Research Grade Eculizumab

Catalog #:   DHB90002 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG2-G4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB90002

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-G4-kappa

Clonality

Monoclonal

Target

CPAMD4, C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5

Concentration

3.38 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01031

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

5G1.1, h5G1.1HuG2/G4, CAS: 219685-50-4

Clone ID

Eculizumab

Data Image
  • Bioactivity
    Detects Human C5 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Eculizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use, PMID: 30402748

Eculizumab: A Review in Generalized Myasthenia Gravis, PMID: 29435915

Eculizumab: A Review in Neuromyelitis Optica Spectrum Disorder, PMID: 32266705

Eculizumab and Beyond: The Past, Present, and Future of Complement Therapeutics, PMID: 31703946

When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies, PMID: 30110670

Eculizumab in secondary atypical haemolytic uraemic syndrome, PMID: 28339660

Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome, PMID: 23738544

Eculizumab in pregnancy: a narrative overview, PMID: 30159857

Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial, PMID: 29685815

Infections associated with the use of eculizumab: recommendations for prevention and prophylaxis, PMID: 27257797

[Eculizumab Treatment for Refractory Generalized Myasthenia Gravis], PMID: 31171753

Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis, PMID: 30768680

Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience, PMID: 32329881

Eculizumab for the treatment of myasthenia gravis, PMID: 32602752

Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature, PMID: 30598332

Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study, PMID: 23623397

Use of Eculizumab for Active Antibody-mediated Rejection That Occurs Early Post-kidney Transplantation: A Consecutive Series of 15 Cases, PMID: 30801549

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria, PMID: 16990386

Eculizumab is Efficacious But Often Not Accessible, PMID: 29746439

Eculizumab use in kidney transplantation, PMID: 26536427

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria, PMID: 31949012

Eculizumab, PMID: 18714106

Eculizumab, PMID: 19740388

High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine, PMID: 28704351

Eculizumab, PMID: 17715500

Eculizumab for catastrophic antiphospholipid syndrome-a case report and literature review, PMID: 30101319

Eculizumab for treatment of asthma, PMID: 22413827

Eculizumab as a treatment for atypical hemolytic syndrome secondary to carfilzomib, PMID: 29716757

Eculizumab: a review of its use in paroxysmal nocturnal haemoglobinuria, PMID: 22085388

Is eculizumab indicated in patients with atypical hemolytic uremic syndrome already on prolonged dialysis? A case report and review of the literature, PMID: 31520126

Eculizumab in renal transplantation, PMID: 23747093

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria, PMID: 18055865

A randomized, double-blind, placebo-controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis, PMID: 23512355

Eculizumab deposits in vessel walls in thrombotic microangiopathy, PMID: 31345584

Eculizumab: another breakthrough, PMID: 28232621

Eculizumab in Renal Transplantation: A 2017 Update, PMID: 28894081

Treating C3 glomerulopathy with eculizumab, PMID: 29329521

Eculizumab: a review of its use in atypical haemolytic uraemic syndrome, PMID: 24249647

[C5: eculizumab], PMID: 25296873

[Paroxysmal nocturnal hemoglobinuria and thrombosis in the era of eculizumab], PMID: 30185704

Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence, PMID: 29288280

C3-mediated extravascular hemolysis in PNH on eculizumab: Mechanism and clinical implications, PMID: 30032749

Eculizumab in the treatment of membranoproliferative glomerulonephritis, PMID: 25402185

[Myasthenia gravis], PMID: 31538208

Eculizumab: A Complementary addition to existing long-term therapies for myasthenia gravis, PMID: 31074870

The use of eculizumab in renal transplantation, PMID: 23516966

Eculizumab in the treatment of atypical haemolytic uraemic syndrome and other complement-mediated renal diseases, PMID: 23486421

Atypical Hemolytic Uremic Syndrome, PMID: 29803280

Eculizumab in Acute Motor Axonal Neuropathy: An Ethical Application of an Off-Label Indication, PMID: 32833730

Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria, PMID: 25356860

Short-Term Efficacy of Eculizumab Therapy in Atypical Hemolytic Uremic Syndrome., PMID:40531252

Thrombotic Microangiopathy After Kidney Pancreas Transplant Managed With Eculizumab and a Calcineurin Inhibitor-free Basiliximab/Belatacept Maintenance Regimen: Between a Rock and a Hard Place., PMID:40519672

Patient-reported outcomes in patients with paroxysmal nocturnal hemoglobinuria treated with crovalimab and approved C5 inhibitors in the phase III COMMODORE 2 and 1 studies., PMID:40515823

Effectiveness and safety of ravulizumab for Japanese patients with atypical hemolytic uremic syndrome switched from eculizumab: an analysis of a post-marketing surveillance., PMID:40515788

DAGLA autoantibody experience at Mayo Clinic., PMID:40512252

Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica., PMID:40506785

Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders., PMID:40506618

Emergent role of complement inhibitors in myasthenic crisis: Understanding why, when and how., PMID:40505554

[A case of paroxysmal nocturnal hemoglobinuria treated with eculizumab in unintended pregnancy]., PMID:40484825

[Diagnosis, treatment, and genetic analysis of five cases of primary atypical hemolytic uremic syndrome]., PMID:40484823

An updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote., PMID:40472799

Complement inhibitor therapy as a steroid-sparing strategy in generalized myasthenia gravis., PMID:40453104

From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis., PMID:40447786

Oral iptacopan monotherapy in paroxysmal nocturnal haemoglobinuria: final 48-week results from the open-label, randomised, phase 3 APPLY-PNH trial in anti-C5-treated patients and the open-label, single-arm, phase 3 APPOINT-PNH trial in patients previously untreated with complement inhibitors., PMID:40447351

Case Report: Hematopoietic Stem Cell Transplantation to Treat Severe Acquired Aplastic Anemia in a Pediatric Kidney Transplant Recipient., PMID:40445946

Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis., PMID:40438181

Atypical Haemolytic Uraemic Syndrome., PMID:40436118

Hypertensive Emergency and Atypical Hemolytic Uremic Syndrome Associated with Cocaine Use: A Diagnostic and Therapeutic Challenge., PMID:40422585

The Role of Complement in the Pathogenesis and Treatment of Myasthenia Gravis., PMID:40422242

Perioperative Management of Atypical Hemolytic Uremic Syndrome in a Patient on Maintenance Eculizumab Therapy: A Case Report and Review of the Literature., PMID:40414204

Validation for soluble C5b-9 detection and comparative analysis of three quantification methods., PMID:40412754

Translating biomarker insights into practice: a path forward in TA-TMA management., PMID:40406401

Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Long-term Follow-up and Therapeutic Challenges in a Treatment-Resistant Case., PMID:40398846

Therapeutics controversies in antineutrophilic cytoplasmic antibody-associated vasculitis., PMID:40392453

Atypical hemolytic uremic syndrome: a rare complication of postendoscopic retrograde cholangiopancreatography pancreatitis., PMID:40386314

Kidney transplant in patients with C3 glomerulopathy., PMID:40385590

PLASMIC score to aid diagnosis of aHUS: an analysis of C5 inhibitor clinical trials and the PINC AI™ healthcare database., PMID:40375186

Incidence of infection associated with eculizumab: a meta-analysis of 9 randomized controlled trials., PMID:40356951

Advancements in Complement Inhibition for PNH and Primary Complement Mediated Thrombotic Microangiopathy., PMID:40354320

Comparative efficacy and acceptability of novel biologics in the treatment of myasthenia gravis: systematic review and network meta-analysis of randomized trials., PMID:40346603

Eculizumab in severe pediatric STEC-HUS and its impact on neurological prognosis-a systematic review and meta-analysis., PMID:40341411

Drug-Induced Thrombotic Microangiopathy Arising During the Treatment of Anal Carcinoma After the Use of Mitomycin C., PMID:40330382

Rapid response of eculizumab: a rescue therapy for ventilator-dependent refractory myasthenic crisis., PMID:40327031

Interferon Causes Endothelial Injury in Humans., PMID:40326264

Clinical Features and Factors Associated With Outcome in Late Adult-Onset Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease., PMID:40324120

Utility of spinal cord axial-T2 sequence in a population-based cohort of multiple sclerosis., PMID:40301133

Complement dysregulation at lymphatics., PMID:40300720

Correction: A real-life experience with eculizumab and efgartigimod in generalized myasthenia gravis patients., PMID:40299078

Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report., PMID:40297820

Eculizumab as Treatment in Refractory Impeding and Myasthenic Crisis: A Case Series., PMID:40295418

Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics., PMID:40292035

Anchored Indirect Treatment Comparison Finds Comparable Effects of Pegcetacoplan and Iptacopan in Paroxysmal Nocturnal Haemoglobinuria., PMID:40285403

Complement in Antibody-Mediated Rejection of the Kidney Graft: From Pathophysiology to Clinical Practice., PMID:40283639

Dose Adjustments of Pegcetacoplan in a Patient With Paroxysmal Nocturnal Hemoglobinuria Undergoing Surgery: A Case Report., PMID:40276419

Characterizing clinically significant extravascular hemolysis in adults with PNH on ravulizumab or eculizumab treatment., PMID:40273330

Neuromyelitis optica spectrum disorder in Latin America: a global data share initiative., PMID:40267692

Treatment of atypical hemolytic uremic syndrome with eculizumab in a patient presenting with neuropsychiatric prodrome: a case report., PMID:40264782

Late Relapse After Autologous Hematopoietic Stem Cell Transplantation in AQP4-IgG-Positive NMOSD., PMID:40257801

The Advancing Landscape of Paroxysmal Nocturnal Hemoglobinuria Treatment., PMID:40257298

Eculizumab is efficacious and safe in pediatric patients with various forms of hemolytic uremic syndrome: a retrospective clinical experience of a tertiary center., PMID:40255570

Datasheet

Document Download

Research Grade Eculizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Eculizumab [DHB90002]
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