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Research Grade Daclizumab

Catalog #:   DHB95801 Specific References (97) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB95801

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

IL2-RA, IL-2R subunit alpha, TAC antigen, IL-2-RA, p55, IL2RA, IL-2 receptor subunit alpha, Interleukin-2 receptor subunit alpha, CD25

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01589

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

BIIB019, DAC HYP, CAS: 152923-56-3

Clone ID

Daclizumab

Data Image
  • Bioactivity
    Detects Human CD25/IL2RA in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Daclizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Daclizumab Therapy for Multiple Sclerosis, PMID: 29661806

Daclizumab in multiple sclerosis, PMID: 29645071

▼ Daclizumab for MS, PMID: 28183723

Daclizumab, PMID: 17916050

Daclizumab: A Review in Relapsing Multiple Sclerosis, PMID: 28211007

Daclizumab for the treatment of multiple sclerosis, PMID: 28849702

Daclizumab for the treatment of adults with relapsing forms of multiple sclerosis, PMID: 28803486

Daclizumab therapy for multiple sclerosis, PMID: 23055048

Daclizumab-induced encephalitis in multiple sclerosis, PMID: 31549941

Daclizumab: Development, Clinical Trials, and Practical Aspects of Use in Multiple Sclerosis, PMID: 28707278

Daclizumab and its use in multiple sclerosis treatment, PMID: 28387383

Daclizumab for relapsing remitting multiple sclerosis, PMID: 22513956

Pharmacokinetic drug evaluation of daclizumab for the treatment of relapsing-remitting multiple sclerosis, PMID: 29363337

Daclizumab for relapsing remitting multiple sclerosis, PMID: 24363032

Daclizumab for relapsing remitting multiple sclerosis, PMID: 20556791

Daclizumab (anti-CD25) in multiple sclerosis, PMID: 24768797

Daclizumab: a review of its use in the management of organ transplantation, PMID: 11707149

Daclizumab: a potential asthma therapy?, PMID: 20804450

Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma, PMID: 17530023

Daclizumab: a review of its use in the prevention of acute rejection in renal transplant recipients, PMID: 10651389

Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis, PMID: 23732529

Characterization of the Impact of Daclizumab Beta on Circulating Natural Killer Cells by Mass Cytometry, PMID: 32391016

Immune-mediated encephalitis with daclizumab: The final nail, PMID: 30073908

End of the road for daclizumab in multiple sclerosis, PMID: 29565004

Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis, PMID: 30657420

A critical appraisal of daclizumab use as emerging therapy in multiple sclerosis, PMID: 25826609

Review of daclizumab and its therapeutic potential in the treatment of relapsing-remitting multiple sclerosis, PMID: 24143075

Long-term safety and efficacy of daclizumab beta in relapsing-remitting multiple sclerosis: 6-year results from the SELECTED open-label extension study, PMID: 32451615

Anti-CD25 (daclizumab) monoclonal antibody therapy in relapsing-remitting multiple sclerosis, PMID: 22284868

Daclizumab for the treatment of relapsing-remitting multiple sclerosis, PMID: 28286970

Daclizumab to prevent rejection after cardiac transplantation, PMID: 15987919

90 Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma, PMID: 32275165

Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis, PMID: 26444729

A fatal case of daclizumab-induced liver failure in a patient with MS, PMID: 30800722

Daclizumab (Zinbryta) for multiple sclerosis, PMID: 27603962

The development of sarcoidosis in patients receiving daclizumab: A case series from multiple clinical trials, PMID: 30885425

Disease modifying therapies for relapsing multiple sclerosis, PMID: 27549763

Anti-interleukin-2 receptor antibodies: basiliximab and daclizumab, PMID: 11522853

Daclizumab use in patients with pediatric multiple sclerosis, PMID: 22232346

Rash developing after cessation of Daclizumab for relapsing remitting MS; a case series, PMID: 31421627

Daclizumab-induced adverse events in multiple organ systems in multiple sclerosis, PMID: 24532277

Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial, PMID: 23562009

Severe cutaneous adverse event in a daclizumab-treated multiple sclerosis patient, PMID: 31228714

Delayed onset hypophysitis after therapy with daclizumab for multiple sclerosis - A report of two cases, PMID: 33387829

Daclizumab induction therapy in liver transplant recipients with renal insufficiency, PMID: 20659283

Daclizumab for treatment of birdshot chorioretinopathy, PMID: 18268208

[Off-label use of biologic agents in the treatment of dermatosis, part 2: etanercept, efalizumab, alefacept, rituximab, daclizumab, basiliximab, omalizumab, and cetuximab], PMID: 18206084

Spotlight on anti-CD25: daclizumab in MS, PMID: 18808743

Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECTION): a multicentre, randomised, double-blind extension trial, PMID: 24656609

A case of immune-mediated encephalitis related to daclizumab therapy, PMID: 30073905

Induction With Antithymocyte Globulin Is Associated With Decreased Mortality and PTLD in Pediatric Liver Transplantation: A UNOS Data Analysis., PMID:40490923

A peek into the pipeline: Expert views on emerging therapies., PMID:40239631

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis., PMID:40107244

Evolving Patterns of Initial RRMS Treatment in Finland (2013-2022): Insights From a Nationwide Multiple Sclerosis Register., PMID:39935206

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT., PMID:39814869

Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation., PMID:39735417

Intrathecal immune reactivity against Measles-, Rubella-, and Varicella Zoster viruses is associated with cerebrospinal fluid inflammation in multiple sclerosis., PMID:39377663

Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis., PMID:39254048

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases., PMID:39226901

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Alterations of Thymus-Derived Tregs in Multiple Sclerosis., PMID:38838284

Induction therapy in heart transplantation: A systematic review and network meta-analysis for developing evidence-based recommendations., PMID:38716786

Interleukin inhibitors and the associated risk of candidiasis., PMID:38605952

Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries., PMID:38547883

The Effect of Induction Therapy on Antibody-Mediated Rejection in Kidney Transplantation: A Network Meta-Analysis Using Recent Data., PMID:38490831

Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis., PMID:38321317

Non-IL-2-blocking anti-CD25 antibody inhibits tumor growth by depleting Tregs and has synergistic effects with anti-CTLA-4 therapy., PMID:38180065

Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis., PMID:38174776

Outcomes of kidney transplantation in patients with IgA nephropathy based on induction: A UNOS data analysis., PMID:38127110

Adverse effects of immunotherapies for multiple sclerosis: a network meta-analysis., PMID:38032059

Network meta-analysis on efficacy and safety of different biologics for ulcerative colitis., PMID:37803294

"No association between disease modifying treatment and fatigue in multiple sclerosis"., PMID:37708819

A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology., PMID:37596262

A Real-World Disproportionality Analysis of Drug-Induced Immune Hemolytic Anemia in the FDA Adverse Event Reporting System., PMID:37522435

Treatment with Biologic Drugs in Pediatric Behçet's Disease: A Comprehensive Analysis of the Published Data., PMID:37382804

Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma., PMID:37198490

A first case of successful using of ibrutinib in treating paraneoplastic pemphigus related bronchiolitis obliterans concurrent with CLL., PMID:37007770

Seizure risk in multiple sclerosis patients treated with disease-modifying therapy: A systematic review and network meta-analysis., PMID:36802988

Dynamics of Inflammatory and Neurodegenerative Biomarkers after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis., PMID:36142860

What Have Failed, Interrupted, and Withdrawn Antibody Therapies in Multiple Sclerosis Taught Us?, PMID:35794296

Novel multiple sclerosis agents-associated cardiotoxicity: A real-world pharmacovigilance study., PMID:35643216

Long-term efficacy and safety of siponimod in patients with secondary progressive multiple sclerosis: Analysis of EXPAND core and extension data up to >5 years., PMID:35380078

The Shared Mechanism and Candidate Drugs of Multiple Sclerosis and Sjögren's Syndrome Analyzed by Bioinformatics Based on GWAS and Transcriptome Data., PMID:35356004

Decreased Intrathecal Concentrations of Free Light Chains Kappa in Multiple Sclerosis Patients Taking Very High Effective Disease-Modifying Treatment., PMID:35328273

Current Knowledge of Biologics in Treatment of Noninfectious Uveitis., PMID:35133890

Trends in the use of disease-modifying therapies among reproductive-aged women with multiple sclerosis in the United States from 2010 to 2019., PMID:35088492

Mechanistic and Biomarker Studies to Demonstrate Immune Tolerance in Multiple Sclerosis., PMID:35069562

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis., PMID:34975899

Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display., PMID:34764369

Meta-Analysis of Interleukin-2 Receptor Antagonists as the Treatment for Steroid-Refractory Acute Graft-Versus-Host Disease., PMID:34621279

Biologic Therapies and Small Molecules for the Management of Non-Infectious Scleritis: A Narrative Review., PMID:34476773

Correction: Bortezomib for anti-NMDAR encephalitis following daclizumab treatment in a patient with multiple sclerosis., PMID:34396130

Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report., PMID:34307578

Bortezomib for anti-NMDAR encephalitis following daclizumab treatment in a patient with multiple sclerosis., PMID:34079936

Impact of Interferons and Biological Drug Inhibitors of IL-2 and IL-6 on Small-Molecule Drug Metabolism Through the Cytochrome P450 System., PMID:34078115

A Network Meta-Analysis of Induction Immunosuppression for Simultaneous Pancreas-Kidney Transplant From Randomized Clinical Trials., PMID:34053419

Multiple sclerosis: doubling down on MHC., PMID:34006391

Datasheet

Document Download

Research Grade Daclizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Daclizumab [DHB95801]
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