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Research Grade Nebacumab

Catalog #:   DXX02201 Specific References (100) DATASHEET
Host species: Human
Isotype: IgM-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DXX02201

Expression system

Mammalian Cells

Species reactivity

Gram negative bacteria

Host species

Human

Isotype

IgM-kappa

Clonality

Monoclonal

Target

Endotoxin (Lipid A)

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

HA-1A, centoxin, septomonab, CAS: 138661-01-5

Clone ID

Nebacumab

Data Image
References

Sepsis management and antiendotoxin therapy after nebacumab. A reappraisal, PMID: 7521827

Centoxin, PMID: 8435673

Marketed therapeutic antibodies compendium, PMID: 22531442

The birth pangs of monoclonal antibody therapeutics: the failure and legacy of Centoxin, PMID: 22531443

Biotechnology and clinical trials, PMID: 11865440

Update on monoclonal antibody therapy in the gram-negative sepsis syndrome, PMID: 1429060

Antiendotoxin monoclonal antibodies. What future now?, PMID: 7848542

Assessment of biotechnology drugs: what are the issues?, PMID: 10538922

Monoclonal antibodies to endotoxin in the management of sepsis, PMID: 8317126

Issues in the adjunct therapy of severe sepsis, PMID: 8877531

Anti-endotoxin monoclonal antibodies, PMID: 1552929

Anti-endotoxin monoclonal antibodies, PMID: 1552919

Monoclonal antibody therapy for gram-negative sepsis: principles, applications, and controversies, PMID: 8469619

Looking back on HA-1A, PMID: 7979833

Advances in the therapy for sepsis in children, PMID: 9057790

Sepsis therapy still shocking, PMID: 9219250

P & T Committee response to evolving technologies: preparing for the launch of high-tech, high-cost products. Roundtable discussion, PMID: 10117768

Single-dose pharmacokinetics and safety of HA-1A, a human IgM anti-lipid-A monoclonal antibody, in pediatric patients with sepsis syndrome, PMID: 8501580

Antiendotoxin antibodies: a dead end?, PMID: 8198349

Anti-endotoxin monoclonal antibodies--a second look, PMID: 1552918

Economic assessment of drugs in Spain, PMID: 10146905

Management of generalized faecal peritonitis, PMID: 1294127

Perspectives for the future, PMID: 8227736

New treatments for sepsis, PMID: 8365201

[Immunotherapy in sepsis syndrome], PMID: 1603159

New drugs on the horizon, PMID: 1534032

The economics of gene therapy and of pharmacogenetics, PMID: 11873384

Gram-negative sepsis, the sepsis syndrome, and the role of antiendotoxin monoclonal antibodies, PMID: 1611812

The search for a magic bullet to fight sepsis, PMID: 8474207

Immunotherapy of sepsis, PMID: 8474114

Lessons learned from clinical trials on monoclonal anti-endotoxin antibody, PMID: 8203986

Management of pre-eclampsia, PMID: 8679381

New treatments for septic shock, PMID: 1741367

Monoclonal antiendotoxin agent HA-1A (Centoxin), PMID: 8093933

[Septomonab (Centoxin) in the treatment of gram-negative septicemia], PMID: 8497944

Anti-endotoxin therapy in primate bacteremia with HA-1A and BPI, PMID: 8024362

Thoughts on drug development, PMID: 1634635

Antiendotoxin therapy in sepsis, PMID: 8398040

[Introduction of immunotherapeutic agents in clinical practice; current status concerning anti-endotoxin antibody HA-1A in the control of sepsis], PMID: 8437630

Anatomy of an antibody, and related misadventures in developing an effective treatment for septic shock, PMID: 8361858

Challenges to the economic evaluation of new biotechnological interventions in healthcare, PMID: 10539393

HA-1A. A human monoclonal antibody for the treatment of gram-negative sepsis, PMID: 1578120

Clinical trials of immunotherapy for sepsis, PMID: 1597020

Human monoclonal antibodies in sepsis, PMID: 1791872

Anti-lipid A monoclonal antibody centoxin (HA-1A) binds to a wide variety of hydrophobic ligands, PMID: 9453659

Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide, PMID: 8418211

Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5, PMID: 8143464

Cost-effectiveness of monoclonal antibodies to gram-negative endotoxin in the treatment of gram-negative sepsis in ICU patients, PMID: 8417245

A controlled trial of HA-1A in a canine model of gram-negative septic shock, PMID: 8474201

Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels, PMID: 1431255

The birth pangs of monoclonal antibody therapeutics: the failure and legacy of Centoxin., PMID:22531443

Marketed therapeutic antibodies compendium., PMID:22531442

The economics of gene therapy and of pharmacogenetics., PMID:11873384

Biotechnology and clinical trials., PMID:11865440

Randomized, placebo-controlled trial of HA-1A, a human monoclonal antibody to endotoxin, in children with meningococcal septic shock. European Pediatric Meningococcal Septic Shock Trial Study Group., PMID:10825037

Challenges to the economic evaluation of new biotechnological interventions in healthcare., PMID:10539393

Assessment of biotechnology drugs: what are the issues?, PMID:10538922

Anti-lipid A monoclonal antibody centoxin (HA-1A) binds to a wide variety of hydrophobic ligands., PMID:9453659

Sepsis therapy still shocking., PMID:9219250

Influence of alterations in foregoing life-sustaining treatment practices on a clinical sepsis trial. The HA-1A Sepsis Study Group., PMID:9118650

Advances in the therapy for sepsis in children., PMID:9057790

Issues in the adjunct therapy of severe sepsis., PMID:8877531

Management of pre-eclampsia., PMID:8679381

The influence of clinical study design on cost-effectiveness projections for the treatment of gram-negative sepsis with human anti-endotoxin antibody., PMID:8924965

Anti-endotoxin human monoclonal antibody A6H4C5 (HA-1A) utilizes the VH4.21 gene., PMID:8845451

The relevance of searching for effects under a clinical-trial lamppost: a key issue., PMID:8544678

Effect of HA-1A monoclonal IgM antibody on endotoxin-induced proliferation of cultured rat middle ear epithelium., PMID:7872606

In vitro effects of HA-1A (Centoxin) on cytokine production in whole blood from intensive care unit patients., PMID:7880671

The French National Registry of HA-1A (Centoxin) in septic shock. A cohort study of 600 patients. The National Committee for the Evaluation of Centoxin., PMID:7979845

Looking back on HA-1A., PMID:7979833

Antiendotoxin monoclonal antibodies. What future now?, PMID:7848542

An evaluation of the hemodynamic effects of HA-1A human monoclonal antibody., PMID:8045141

Antiendotoxin antibodies: a dead end?, PMID:8198349

Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group., PMID:8198341

Anti-endotoxin therapy in primate bacteremia with HA-1A and BPI., PMID:8024362

Projected impact of monoclonal anti-endotoxin antibody therapy., PMID:8203991

Lessons learned from clinical trials on monoclonal anti-endotoxin antibody., PMID:8203986

Sepsis management and antiendotoxin therapy after nebacumab. A reappraisal., PMID:7521827

HA-1A in septic patients with ARDS: results from the pivotal trial., PMID:7930026

The HA-1A saga: the scientific and ethical dilemma of innovative and costly therapies., PMID:7930023

Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5., PMID:8143464

Economic assessment of drugs in Spain., PMID:10146905

Cost-effectiveness of HA-1A treatment for patients with sepsis., PMID:7831376

[A cost-effectiveness analysis of treatment with antiendotoxin monoclonal antibodies in gram-negative sepsis]., PMID:8289526

[Is it possible to treat infections with non-antimicrobial agents?]., PMID:8142499

[Initial experience with monoclonal antibodies in therapy of life threatening nosocomial infections in the neonatal period]., PMID:8114779

New treatments for sepsis., PMID:8365201

Introduction of new technology into critical care practice: a history of HA-1A human monoclonal antibody against endotoxin., PMID:8339592

Monoclonal antibodies, new technologies, and critical care medicine., PMID:8339573

Anatomy of an antibody, and related misadventures in developing an effective treatment for septic shock., PMID:8361858

Single-dose pharmacokinetics and safety of HA-1A, a human IgM anti-lipid-A monoclonal antibody, in pediatric patients with sepsis syndrome., PMID:8501580

Antiendotoxin therapy in sepsis., PMID:8398040

The search for a magic bullet to fight sepsis., PMID:8474207

A controlled trial of HA-1A in a canine model of gram-negative septic shock., PMID:8474201

Survival in selected patients with gram-negative sepsis after adjunctive therapy with HA-1A., PMID:8096292

Centoxin: the full story of its withdrawal., PMID:8490694

Centoxin: the full story of its withdrawal., PMID:8490693

[Septomonab (Centoxin) in the treatment of gram-negative septicemia]., PMID:8497944

[Preventive interruption of the administration of HA-1A monoclonal antibody against endotoxin]., PMID:8479241

Immunotherapy of sepsis., PMID:8474114

Datasheet

Document Download

Research Grade Nebacumab.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

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Research Grade Nebacumab [DXX02201]
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