Catalog No.
YHJ91801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly1023-Ala1304
Predicted molecular weight
33.91 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6Q9
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RAC-3, Class E basic helix-loop-helix protein 42, NCoA-3, Steroid receptor coactivator protein 3, bHLHe42, TRAM-1, ACTR, Receptor-associated coactivator 3, TRAM1, RAC3, BHLHE42, SRC-3, pCIP, Amplified in breast cancer 1 protein, AIB-1, Thyroid hormone receptor activator molecule 1, CBP-interacting protein, AIB1, NCOA3, Nuclear receptor coactivator 3
Note
For research use only.
Mullerian adenosarcoma: clinicopathologic and molecular characterization highlighting recurrent BAP1 loss and distinctive features of high-grade tumors., PMID:36138078
SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment., PMID:36263184
Circ_0001667 Promotes Adriamycin Resistance and Malignant Progression via Targeting the miR-193a-5p/Rap2A Molecular Axis in Breast Cancer., PMID:36289041
Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment., PMID:36316775
Nuclear receptor coactivator 3 transactivates proinflammatory cytokines in collagen-induced arthritis., PMID:36323191
NCOA1/2/3 rearrangements in uterine tumor resembling ovarian sex cord tumor: A clinicopathological and molecular study of 18 cases., PMID:36646185
Two target gene activation pathways for orphan ERR nuclear receptors., PMID:36646760
Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis., PMID:36658474
Estrogen-dependent activation of NCOA3 couples with p300 and NF-κB to mediate antiapoptotic genes in ER-positive breast cancer cells., PMID:36853387
Clinicopathologic and genetic characterization of angiofibroma of soft tissue: a study of 12 cases including two cases with AHRR::NCOA3 gene fusion., PMID:36860189
NCoA3 upregulation in breast cancer‑associated adipocytes elicits an inflammatory profile., PMID:37026525
Uterine Tumor Resembling Ovarian Sex Cord Tumors: 23 Cases Indicating Molecular Heterogeneity With Variable Biological Behavior., PMID:37132508
Cellular myofibromas with SRF fusions: clinicopathological and molecular study of 3 cases of a rare entity and a potential mimic of sarcoma., PMID:37245628
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study., PMID:37327205
Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma., PMID:37335673
Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer., PMID:37363949
USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice., PMID:37415159
KAT6A::EP300 fusion in congenital myeloid sarcoma: Yet another novel molecular marker indicating spontaneous remission?: A case report., PMID:37505185
Intrinsically Disordered Flanking Regions Increase the Affinity of a Transcriptional Coactivator Interaction across Vertebrates., PMID:37647499
AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer., PMID:37711895
Novel NCOA2/3-rearranged low-grade fibroblastic spindle cell tumors: A report of five cases., PMID:37724942
Immune cell-specific and common molecular signatures in rheumatoid arthritis through molecular network approaches., PMID:37852410
A case of spindle cell rhabdomyosarcoma with a ZFP64::NCOA3 fusion., PMID:37905771
Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy., PMID:37957697
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts., PMID:37978056
Clinicopathological features and molecular genetic changes in 17 cases of uterine tumor resembling ovarian sex cord tumor., PMID:38000680
Pediatric NCOA3-rearranged low-grade fibroblastic tumor with nuclear beta-catenin immunoreactivity., PMID:38340030
Whole genome sequencing of a family with autosomal dominant features within the oculoauriculovertebral spectrum., PMID:38370836
GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases., PMID:38379791
Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy., PMID:38483947
The Molecular Evolution of Melanoma Distant Metastases., PMID:38582370
Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis., PMID:38614406
Evaluation of the diagnostic utility of NCOA3, Maspin and VHL protein expression in pancreatic ductal adenocarcinoma: An immunohistochemical study., PMID:38901088
Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress., PMID:38969334
Key target genes related to anti-breast cancer activity of ATRA: A network pharmacology, molecular docking and experimental investigation., PMID:39108872
Unraveling the Molecular Landscape of Uterine Tumor Resembling Ovarian Sex Cord Tumor: Insights From A Clinicopathological, Morphologic, Immunohistochemical, and Molecular Analysis of 35 Cases., PMID:39265954
Differential proteins from EVs identification based on tandem mass tags analysis and effect of Treg-derived EVs on T-lymphocytes in COPD patients., PMID:39342213
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts., PMID:39487265
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2)., PMID:39593108
FOXF2 expression triggered by endocrine therapy orchestrates therapeutic resistance through reorganization of chromatin architecture in breast cancer., PMID:39828125
Case Report: ESR1::CITED2 Fusion in a Malignant Uterine Tumor Resembling Ovarian Sex Cord Tumor., PMID:39869077
Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer., PMID:39921753
PFKFB4 promotes endometrial cancer by regulating glycolysis through SRC‑3 phosphorylation., PMID:40116122
Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression., PMID:40186033
NCOA3 impairs the efficacy of anti-PD-L1 therapy via HSP90α/EZH2/CXCL9 axis in colon cancer., PMID:40215778
Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis., PMID:40241612
Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR-23a-3p-Mediated NCOA3 Expression., PMID:40331881
Structural proteomics defines a sequential priming mechanism for the progesterone receptor., PMID:40355435
Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer., PMID:40434408
Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein-Mediated N6-Methyladenosine Modification of Nuclear Receptor Coactivator 3., PMID:40491173
For research use only. Not for human or drug use.
