Catalog No.
YHJ83301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn300
Predicted molecular weight
35.91 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UQB8
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BAI-associated protein 2, Insulin receptor substrate p53, IRS-58, BAI1-associated protein 2, IRSp53, Insulin receptor substrate p53/p58, Fas ligand-associated factor 3, BAIAP2, FLAF3, Insulin receptor substrate protein of 53 kDa, Brain-specific angiogenesis inhibitor 1-associated protein 2, Protein BAP2, IRSp53/58
Note
For research use only.
Superresolution microscopy reveals distinct localisation of full length IRSp53 and its I-BAR domain protein within filopodia., PMID:30792430
IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration., PMID:30893014
Disruption of Robo2-Baiap2 integrated signaling drives cystic disease., PMID:31534052
Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination., PMID:31717665
Quantitative investigation of negative membrane curvature sensing and generation by I-BARs in filopodia of living cells., PMID:31728468
[Identification of a 17q25.3 duplication in a Chinese patient with global developmental delay and multiple congenital anomalies]., PMID:31922597
IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes., PMID:32116566
Light-Inducible Generation of Membrane Curvature in Live Cells with Engineered BAR Domain Proteins., PMID:32212723
Physiological Tau Interactome in Brain and Its Link to Tauopathies., PMID:32357304
BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study., PMID:32388796
IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells., PMID:32535200
Hyperactive ACC-MDT Pathway Suppresses Prepulse Inhibition in Mice., PMID:32621612
IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules., PMID:32665580
Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio)., PMID:32692463
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme., PMID:32975518
Identification of four differentially expressed genes associated with acute and chronic spinal cord injury based on bioinformatics data., PMID:33229721
Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-κB and Impaired Mobility of HUVECs., PMID:33506012
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion., PMID:33609460
Screening of tumor grade-related mRNAs and lncRNAs for Esophagus Squamous Cell Carcinoma., PMID:33960436
The WAVE complex associates with sites of saddle membrane curvature., PMID:34096975
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53., PMID:34114563
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease., PMID:34523824
E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis., PMID:34616498
Scaffolding proteins in pediatric glioma., PMID:34705668
Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin., PMID:34839189
Expression of actin- and oxidative phosphorylation-related transcripts across the cortical visuospatial working memory network in unaffected comparison and schizophrenia subjects., PMID:35034100
Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis., PMID:35159257
IRSp53 promotes postsynaptic density formation and actin filament bundling., PMID:35819332
De novo DNA methylation induced by circulating extracellular vesicles from acute coronary syndrome patients., PMID:35830762
Identification of TRAPPC9 and BAIAP2 Gene Polymorphisms and Their Association With Fat Deposition-Related Traits in Hu Sheep., PMID:35865874
Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice., PMID:35982261
Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice., PMID:36317872
HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression., PMID:36520027
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation., PMID:36626552
Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers., PMID:36698307
Poor Prognostic Biomarker KIAA1522 Is Associated with Immune Infiltrates in Hepatocellular Carcinoma., PMID:36761433
Association of Plant-Based and High-Protein Diets with a Lower Obesity Risk Defined by Fat Mass in Middle-Aged and Elderly Persons with a High Genetic Risk of Obesity., PMID:36839421
Negatively curved cellular membranes promote BAIAP2 signaling hub assembly., PMID:36943331
Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment., PMID:37211381
Hippocampal BAIAP2 prevents chronic mild stress-induced depression-like behaviors in mice., PMID:37234209
Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in Actin-Based Force Generation., PMID:37685917
The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice., PMID:37730842
Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis., PMID:37762215
A lissencephaly-associated BAIAP2 variant causes defects in neuronal migration during brain development., PMID:38149472
Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation., PMID:38162289
DNA methylation and chromatin accessibility predict age in the domestic dog., PMID:38263575
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation., PMID:38724689
Nano-mechanical Immunoengineering: Nanoparticle Elasticity Reprograms Tumor-Associated Macrophages via Piezo1., PMID:39079080
BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology., PMID:39093051
ADAMTS5 Modulates Breast Cancer Development as a Diagnostic Biomarker and Potential Tumour Suppressor, Regulated by BAIAP2-AS1, CRNDE and hsa-miR-135b-3p: Integrated Systems Biology and Experimental Approach., PMID:40472834
For research use only. Not for human or drug use.
