Catalog No.
YHJ75501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser124
Predicted molecular weight
15.93 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHA4
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, Mitogen-activated protein kinase kinase 1-interacting protein 1, Ragulator complex protein LAMTOR3, LAMTOR3, MAP2K1IP1, MAPKSP1, MEK-binding partner 1, Mitogen-activated protein kinase scaffold protein 1, Mp1
Note
For research use only.
Organization and regulation of mitogen-activated protein kinase signaling pathways., PMID:10209154
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties., PMID:10823939
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment., PMID:11266467
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction., PMID:12479806
Regulation of MAP kinase signaling modules by scaffold proteins in mammals., PMID:14570565
The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling., PMID:15016825
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals., PMID:15923628
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis., PMID:17178906
Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer., PMID:17254543
MEK-ERK is involved in SUMO-1 foci formation on apoptosis., PMID:17284251
Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development., PMID:18823331
Protein scaffolds in MAP kinase signalling., PMID:19091303
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes., PMID:19177150
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids., PMID:20381137
Interactions between kinase scaffold MP1/p14 and its endosomal anchoring protein p18., PMID:21452851
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation., PMID:22143885
Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk., PMID:23341997
Gastrin-induced proliferation involves MEK partner 1 (MP1)., PMID:23408059
Stability of the endosomal scaffold protein LAMTOR3 depends on heterodimer assembly and proteasomal degradation., PMID:23653355
PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis., PMID:24209743
p18/LAMTOR1: a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway., PMID:24377928
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration., PMID:24841562
A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk., PMID:25661340
Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex., PMID:28334111
BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer., PMID:28606806
Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice., PMID:28821221
Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii., PMID:28830458
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex., PMID:29107538
Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane., PMID:29285400
Gene Expression and Localization of LAMTOR3 in the Skin Cells of Liaoning Cashmere Goats., PMID:29564941
Dysregulated mitogen-activated protein kinase pathway mediated cell cycle disruption in sporadic parathyroid tumors., PMID:31535356
[Expression and Clinical Significance of Late Endosomal/Lysosomal Adaptor,Mitogen-activated Protein Kinase and Mammalian Target of Rapamycin Activator 3 in Bladder Carcinoma]., PMID:31699189
The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas., PMID:31834371
P38-β/SAPK-inhibiting and apoptosis-inducing activities of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene) amino)phenol., PMID:32394730
Identification and Validation of Potential miRNAs, as Biomarkers for Sepsis and Associated Lung Injury: A Network-Based Approach., PMID:33182754
Circ_0075829 facilitates the progression of pancreatic carcinoma by sponging miR-1287-5p and activating LAMTOR3 signalling., PMID:33184989
MiR-20a suppresses proliferation and facilitates apoptosis of breast cancer cells via the MTOR signaling pathway., PMID:33275232
Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1., PMID:35608036
Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis., PMID:35959437
LAMTOR3 is a prognostic biomarker in kidney renal clear cell carcinoma., PMID:36082464
Alterations in gene expressions of Caco-2 cell responses to LPS and ploy(I:C) stimulation., PMID:37304876
Identifying key pathogenic mechanisms and potential intervention targets for recurrence after laryngeal cancer treatment through bioinformatics screening., PMID:39145096
For research use only. Not for human or drug use.
