Catalog No.
YHJ62901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly44-Leu353
Predicted molecular weight
37.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NPC4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gb3 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, CD77 synthase, Alpha-1,4-N-acetylglucosaminyltransferase, Lactosylceramide 4-alpha-galactosyltransferase, Alpha4Gal-T1, Alpha-1,4-galactosyltransferase, A4GALT1, A4GALT, Globotriaosylceramide synthase, P1/Pk synthase, A14GALT
[Study of the types of mutations of Thalassemia in Shanghai area]., PMID:38565501
Lectin-anticancer peptide fusion demonstrates a significant cancer-cell-selective cytotoxic effect and inspires the production of "clickable" anticancer peptide in Escherichia coli., PMID:37916438
One of the two N-glycans on the human Gb3/CD77 synthase is essential for its activity and allosterically regulates its function., PMID:35671609
Shiga Toxins as Antitumor Tools., PMID:34678982
Two Paralogous Gb3/CD77 Synthases in Birds Show Different Preferences for Their Glycoprotein and Glycosphingolipid Substrates., PMID:34575935
Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable., PMID:33978735
Shiga Toxins: An Update on Host Factors and Biomedical Applications., PMID:33803852
Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry., PMID:33460651
The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection., PMID:32507026
Verotoxin-1-Induced ER Stress Triggers Apoptotic or Survival Pathways in Burkitt Lymphoma Cells., PMID:32403276
Verotoxin Receptor-Based Pathology and Therapies., PMID:32296648
Fabry Disease With Concomitant Lewy Body Disease., PMID:32016321
Designing and Analyzing the Structure of DT-STXB Fusion Protein as an Anti-tumor Agent: An in Silico Approach., PMID:31754360
Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury., PMID:31101366
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome., PMID:30404007
Acquired Resistance to Shiga Toxin-Induced Apoptosis by Loss of CD77 Expression in Human Myelogenous Leukemia Cell Line, THP-1., PMID:30175782
Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells., PMID:30122443
Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system., PMID:29709005
Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells., PMID:29440708
Intracellular drug delivery: Potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy., PMID:29432805
Streptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium., PMID:28407026
oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages., PMID:27870891
Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase., PMID:27538840
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies., PMID:26883028
Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit., PMID:26826119
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens., PMID:26773500
The cell-surface proteome of cultured adipose stromal cells., PMID:25929697
Bovine macrophages sense Escherichia coli Shiga toxin 1., PMID:25907071
Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle., PMID:25889651
Interfering parameters in the determination of urinary globotriaosylceramide (Gb3) in patients with chronic kidney disease., PMID:25857295
Upregulation of Shiga toxin receptor CD77/Gb3 and interleukin-1β expression in the brain of EHEC patients with hemolytic uremic syndrome and neurologic symptoms., PMID:24989888
Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure., PMID:24909663
Shiga toxin 1, as DNA repair inhibitor, synergistically potentiates the activity of the anticancer drug, mafosfamide, on raji cells., PMID:23430607
An innovative method to identify autoantigens expressed on the endothelial cell surface: serological identification system for autoantigens using a retroviral vector and flow cytometry (SARF)., PMID:23401699
Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas., PMID:23243310
Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro., PMID:23242319
Hypercalcemia induces a proinflammatory phenotype in rat leukocytes and endothelial cells., PMID:23011779
Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation., PMID:22944681
Facing glycosphingolipid-Shiga toxin interaction: dire straits for endothelial cells of the human vasculature., PMID:22766973
Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis., PMID:21914445
Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor., PMID:21908601
Establishment of recombinant hybrid-IgG/IgA immunoglobulin specific for Shiga toxin., PMID:21883352
Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase., PMID:21660412
Biochemical, pathological and oncological relevance of Gb3Cer receptor., PMID:21069478
Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups., PMID:20971946
On the structural diversity of Shiga toxin glycosphingolipid receptors in lymphoid and myeloid cells determined by nanoelectrospray ionization tandem mass spectrometry., PMID:20623712
Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect., PMID:19948172
Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells., PMID:19895884
IL-21 and IL-10 have redundant roles but differential capacities at different stages of Plasma Cell generation from human Germinal Center B cells., PMID:19762555
CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells., PMID:19494283
For research use only. Not for human or drug use.
