Catalog No.
YHJ56001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu241-Glu399
Predicted molecular weight
20.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H2X3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DC-SIGNR, DC-SIGN2, CLEC4M, DC-SIGN-related protein, C-type lectin domain family 4 member M, CD299, L-SIGN, CD209L, Liver/lymph node-specific ICAM-3-grabbing non-integrin, CD209L1, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, CD209 antigen-like protein 1
MCP-1 Reduction by L-SIGN Expression in Dengue Virus-Infected Liver Endothelial Cells., PMID:40143272
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D., PMID:39791910
Simultaneous Blockade of CD209 and CD209L by Monoclonal Antibody Does Not Provide Sufficient Protection Against Multiple Viral Infections In Vivo., PMID:39783143
Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever., PMID:38791534
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels., PMID:38320121
Levels of APE1 Repair Gene and CLEC4M in Lung Cancer Patients Receiving Cisplatin Chemotherapy., PMID:38028841
Comprehensive analysis of SARS-CoV-2 receptor proteins in human respiratory tissues identifies alveolar macrophages as potential virus entry site., PMID:36700825
SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues., PMID:34502134
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies., PMID:34464958
L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus., PMID:34291736
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist., PMID:34015061
ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection., PMID:33880537
Identifying epitopes for cluster of differentiation and design of new peptides inhibitors against human SARS-CoV-2 spike RBD by an in-silico approach., PMID:33364503
An investigation into the molecular basis of cancer comorbidities in coronavirus infection., PMID:32970391
Immunohistochemical Study of SARS-CoV-2 Viral Entry Factors in the Cornea and Ocular Surface., PMID:32826650
[Comparative analysis of structural characteristics and epitopes in S proteins between SARS-CoV-2 and SARS-CoV]., PMID:32762171
Common Genetic Variants in ABO and CLEC4M Modulate the Pharmacokinetics of Recombinant FVIII in Severe Hemophilia A Patients., PMID:32726853
CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma., PMID:32705212
DC/L-SIGNs of hope in the COVID-19 pandemic., PMID:32374430
Efficient functional screening of a cellular cDNA library to identify severe fever with thrombocytopenia syndrome virus entry factors., PMID:32265454
Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis., PMID:30944176
The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner., PMID:30740857
Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors., PMID:29894153
Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients., PMID:29389944
DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users., PMID:29140443
Dissecting Multivalent Lectin-Carbohydrate Recognition Using Polyvalent Multifunctional Glycan-Quantum Dots., PMID:28786666
Overexpression of Ebola virus envelope GP1 protein., PMID:28458053
DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis., PMID:28403883
Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis., PMID:28109307
Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences., PMID:27859859
DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans., PMID:27334579
Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran., PMID:27309478
Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis., PMID:26990254
Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus., PMID:26984731
Association of DC-SIGNR Expression in Peripheral Blood Mononuclear Cells with DC-SIGNR Genotypes in HIV-1 Infection., PMID:26313015
Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells., PMID:26150177
CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease., PMID:25832887
Association of CD209L tandem repeats polymorphism with susceptibility to human immunodeficiency virus-1 infection, disease progression, and treatment outcomes: a Moroccan cohort study., PMID:25656622
Characterization of the duplicate L-SIGN and DC-SIGN genes in miiuy croaker and evolutionary analysis of L-SIGN in fishes., PMID:25596146
The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer., PMID:25504222
NMR evidence for oligosaccharide release from the dendritic-cell specific intercellular adhesion molecule 3-grabbing non-integrin-related (CLEC4M) carbohydrate recognition domain at low pH., PMID:24976257
CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection., PMID:24965233
Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population., PMID:24874302
Role of N-linked glycans in the interactions of recombinant HCV envelope glycoproteins with cellular receptors., PMID:24766301
Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin., PMID:24623090
The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads., PMID:24283933
Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus., PMID:24183720
DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection., PMID:24156700
Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulin., PMID:23859015
Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments., PMID:23788638
For research use only. Not for human or drug use.
