Catalog No.
YHJ26401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser223-His410
Predicted molecular weight
22.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NHL6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIR1, Immunoglobulin-like transcript 2, MIR7, CD85 antigen-like family member J, Monocyte/macrophage immunoglobulin-like receptor 7, ILT-2, Leukocyte immunoglobulin-like receptor subfamily B member 1, LIR-1, CD85j, ILT2, LILRB1, MIR-7, Leukocyte immunoglobulin-like receptor 1
LILRB1-directed CAR-T cells for the treatment of hematological malignancies., PMID:40186066
Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB+ T-cell functions to combat MHC-II-expressing tumors., PMID:40169283
Peripheral monocyte subsets are altered during gestation in oocyte donation pregnancy complicated with pre-eclampsia., PMID:39920890
HLA-G can be transfered via trogocytosis from leukemic cells to T cells in chronic lymphocytic leukemia., PMID:39541623
Novel Compound Heterozygous Variants in the FAS Gene Lead to Fetal Onset of Autoimmune Lymphoproliferative Syndrome (ALPS)., PMID:39384643
LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis., PMID:39030302
Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis., PMID:38982045
MHC1/LILRB1 axis as an innate immune checkpoint for cancer therapy., PMID:38911856
Alterations in exhausted and classical memory B cells in lupus nephritis - Relationship with disease relapse., PMID:38878808
ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms., PMID:38393969
Clinicopathologic features of relapsed CD19(-) B-ALL in CD19-targeted immunotherapy: Biological insights into relapse and LILRB1 as a novel B-cell marker for CD19(-) B lymphoblasts., PMID:38177979
Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer., PMID:37781391
HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease., PMID:37686397
Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma., PMID:37142967
A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia., PMID:37057942
Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients., PMID:36925435
Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo., PMID:36831297
TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients., PMID:36812290
Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure., PMID:36713400
Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages., PMID:36389667
The predictive value of NKG2C+NK cells and LILRB1+NK cells in recurrent spontaneous abortion., PMID:36150086
A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases., PMID:36104364
Different classes of genomic inserts contribute to human antibody diversity., PMID:36037353
Natural killer cell profiles in recurrent pregnancy loss: Increased expression and positive associations with TACTILE and LILRB1., PMID:36004818
Increased ILT2 expression contributes to dysfunction of CD56dimCD16+NK cells in chronic hepatitis B virus infection., PMID:35917968
Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample., PMID:35754199
Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells., PMID:35600048
Natural LILRB1 D1-D2 variants show frequency differences in populations and bind to HLA class I with various avidities., PMID:35562487
Changes in the natural killer cell repertoire and function induced by the cancer immune adjuvant candidate IMMUNEPOTENT-CRP., PMID:35381435
Analysis of the expression and prognosis for leukocyte immunoglobulin-like receptor subfamily B in human liver cancer., PMID:35321724
HLA-G-ILT2 interaction contributes to suppression of bone marrow B cell proliferation in acquired aplastic anemia., PMID:35041051
mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation., PMID:34725108
B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor., PMID:34659215
Tumor infiltrating and peripheral CD4+ILT2+ T cells are a cytotoxic subset selectively inhibited by HLA-G in clear cell renal cell carcinoma patients., PMID:34186161
LILRB1: A Novel Diagnostic B-Cell Marker to Distinguish Neoplastic B Lymphoblasts From Hematogones., PMID:34160005
Transcriptomics of type 2 diabetic and healthy human neutrophils., PMID:34134627
Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma., PMID:34098344
Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer., PMID:34054869
Differences in the Expression of KIR, ILT Inhibitory Receptors, and VEGF Production in the Induced Decidual NK Cell Cultures of Fertile and RPL Women., PMID:33997038
Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity., PMID:33861802
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G., PMID:33737343
HLA-G/LILRBs: A Cancer Immunotherapy Challenge., PMID:33563576
ANGPTL2 Induces Synovial Inflammation via LILRB2., PMID:33538932
Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC., PMID:33505397
The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?, PMID:33213057
Soluble HLA-G and HLA-G Bearing Extracellular Vesicles Affect ILT-2 Positive and ILT-2 Negative CD8 T Cells Complementary., PMID:32973812
Decidualization Process Induces Maternal Monocytes to Tolerogenic IL-10-Producing Dendritic Cells (DC-10)., PMID:32973738
Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation., PMID:32918786
RIFINing Plasmodium-NK Cell Interaction., PMID:32800428
Leukocyte immunoglobulin-like receptor subfamily B member 1 potentially acts as a diagnostic and prognostic target in certain subtypes of adenocarcinoma., PMID:32534335
For research use only. Not for human or drug use.
