Catalog No.
YHJ18601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His410
Predicted molecular weight
48.63 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IWB7
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FENS-1, Zinc finger FYVE domain-containing protein 17, WD40- and FYVE domain-containing protein 1, FYVE domain-containing protein localized to endosomes 1, KIAA1435, ZFYVE17, WDFY1, FENS1, WD repeat and FYVE domain-containing protein 1, Phosphoinositide-binding protein 1, WDF1
Note
For research use only.
Alternative splicing and bioinformatic analysis of human U12-type introns., PMID:17332017
Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice., PMID:19228596
Membrane insertion of the FYVE domain is modulated by pH., PMID:19296456
Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance., PMID:23149913
Angiogenic growth factor axis in autophagy regulation., PMID:23388383
Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis., PMID:23845568
Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue., PMID:24659297
WDFY1 mediates TLR3/4 signaling by recruiting TRIF., PMID:25736436
Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway., PMID:25736437
Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells., PMID:26208102
Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology., PMID:26560516
NRP2 transcriptionally regulates its downstream effector WDFY1., PMID:27026195
Cyclosporin A induces autophagy in cardiac fibroblasts through the NRP-2/WDFY-1 axis., PMID:29501733
PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal., PMID:30097850
Hes1 attenuates type I IFN responses via VEGF-C and WDFY1., PMID:31015298
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer., PMID:32123095
Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob/ob Mice., PMID:32296847
Wdfy1 deficiency impairs Tlr3-mediated immune responses in vivo., PMID:32398807
Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1., PMID:32477064
Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer's disease., PMID:33059746
p39-associated Cdk5 activity regulates dendritic morphogenesis., PMID:33127972
RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis., PMID:34394104
miR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1., PMID:35011620
WDFY1, a WD40 repeat protein, is not essential for spermatogenesis and male fertility in mice., PMID:35121371
Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy., PMID:36103833
Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse., PMID:36241655
ANKRD22 is a potential novel target for reversing the immunosuppressive effects of PMN-MDSCs in ovarian cancer., PMID:36822671
CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids., PMID:37541258
Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice., PMID:37645711
Lowering Hippocampal miR-29a Expression Slows Cognitive Decline and Reduces Beta-Amyloid Deposition in 5×FAD Mice., PMID:37989983
Hypothalamic and hippocampal transcriptome changes in AppNL-G-F mice as a function of metabolic and inflammatory dysfunction., PMID:39002757
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival., PMID:39744815
Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1., PMID:39839352
WDFY1-expressing follicular dendritic cells play a critical role in lupus development in cGVHD mouse model., PMID:40169152
Regulation of WDFY1 Expression by miRNAs, Transcription Factors, and IL-6 in Murine Mesangial Cells., PMID:40497974
For research use only. Not for human or drug use.
