Catalog No.
YHJ18201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln443-Gln685
Predicted molecular weight
28.77 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IUC6
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRVTIRB, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, TICAM-1, TICAM1, TRIF, TIR domain-containing adapter protein inducing IFN-beta, TIR domain-containing adapter molecule 1, Proline-rich, vinculin and TIR domain-containing protein B, MyD88-3
Note
For research use only.
A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response to Mycobacterium tuberculosis and Co-Infection with HIV., PMID:32858917
Integration of innate immune signalling by caspase-8 cleavage of N4BP1., PMID:32971525
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling., PMID:33057840
Polysaccharides extract from Vaccaria segetalis seeds inhibits kidney infection by regulating cathelicidin expression., PMID:33141055
Cutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway., PMID:33178195
SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway., PMID:33718825
Toll-like receptor 4-mediated necroptosis in the development of necrotizing enterocolitis., PMID:33731807
Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages., PMID:33858242
Evaluation of Toll-like receptor 3 (TLR3) signaling pathway genes and its genetic polymorphisms in ectopic and eutopic endometrium of women with endometriosis., PMID:33892179
Lipopolysaccharide from biofilm-forming Pseudomonas aeruginosa PAO1 induces macrophage hyperinflammatory responses., PMID:33909550
SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways., PMID:33913550
Whole‑genome identification and systematic analysis of lncRNA‑mRNA co‑expression profiles in patients with cutaneous basal cell carcinoma., PMID:34278484
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses., PMID:34414698
SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon., PMID:34437657
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor-mediated inflammatory responses., PMID:34819358
Immunotherapeutic role of cabazitaxel treatment in the activation of TLR3 signalling in metastatic castration-resistant prostate cancer in vitro., PMID:34826050
Heterologous Expression and Assembly of Human TLR Signaling Components in Saccharomyces cerevisiae., PMID:34827735
Multifaceted roles of TAX1BP1 in autophagy., PMID:35470757
Anti-Inflammatory Activity of Glabralactone, a Coumarin Compound from Angelica sinensis, via Suppression of TRIF-Dependent IRF-3 Signaling and NF-κB Pathways., PMID:35586367
Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling., PMID:35812397
Downregulated TICAM1 is a prognostic biomarker and associated with immune tolerance of Wilms tumor patients., PMID:35933370
A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins., PMID:36056415
Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes., PMID:36056542
Necroptosis at a glance., PMID:36098620
Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer., PMID:36588538
Hypoxia Attenuates Colonic Innate Immune Response and Inhibits TLR4/NF-κB Signaling Pathway in Lipopolysaccharide-Induced Colonic Epithelial Injury Mice., PMID:36603105
Protective effect of Buddha's Temple extract against tert-butyl hydroperoxide stimulation-induced oxidative stress in DF-1 cells., PMID:36915926
Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis., PMID:36978183
HIV-1 Tat Upregulates TREM1 Expression in Human Microglia., PMID:37326481
Integrated approaches for the recognition of small molecule inhibitors for Toll-like receptor 4., PMID:37576745
[Association of gene polymorphisms of MyD88 and TICAM1 and their interactions with community-acquired pneumonia in children]., PMID:37668025
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay., PMID:37811950
Regional modulation of toll-like receptor signaling pathway genes in acute epididymitis in mice., PMID:38497291
Key roles for phosphorylation and the Coiled-coil domain in TRIM56-mediated positive regulation of TLR3-TRIF-dependent innate immunity., PMID:38556084
Functional mechanism of baicalein in alleviating severe acute pancreatitis-acute lung injury by blocking the TLR4/MyD88/TRIF signaling pathway., PMID:38557861
Toll-like receptor signaling pathway involved in pathogenesis of thromboangiitis obliterans through activating of NF-κB., PMID:38640750
Evaluation of Toll-like Receptor 4 (TLR4) Involvement in Human Atrial Fibrillation: A Computational Study., PMID:38790263
Structural insights into the role of deleterious mutations at the dimeric interface of Toll-like receptor interferon-β related adaptor protein., PMID:38814166
TLR4 inhibitors through inhibiting (MYD88-TRIF) pathway, protect against experimentally-induced intestinal (I/R) injury., PMID:38850786
Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil., PMID:38864429
Programming Bordetella pertussis lipid A to promote adjuvanticity., PMID:39272136
Suppression of intestinal Ticam1 ameliorated MASH via Akkermansia muciniphila QAA37749.1 mediated betaine transformation., PMID:39536991
Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM., PMID:39786929
Toll-like receptor 4 pathway evolutionary trajectory and functional emergence., PMID:39902049
Interventional Effects of Edible Bird's Nest and Free Sialic Acids on LPS-Induced Brain Inflammation in Mice., PMID:39940389
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells., PMID:40029556
Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice., PMID:40068794
ARNAX is an ideal adjuvant for COVID-19 vaccines to enhance antigen-specific CD4+ and CD8+ T-cell responses and neutralizing antibody induction., PMID:40231823
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
Poly-IC Alleviates Nitroglycerin-Induced Migraine by Inhibiting Neuroinflammation via TLR3/TRIF Signaling Pathway., PMID:40406905
For research use only. Not for human or drug use.
