Catalog No.
YHH09501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe62-Tyr321
Predicted molecular weight
32.08 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15418
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p90-RSK 1, Ribosomal S6 kinase 1, RSK1, p90RSK1, RPS6KA1, MAPKAP kinase 1a, MAPK-activated protein kinase 1a, RSK-1, MAPKAPK1A, MAP kinase-activated protein kinase 1a, MAPKAPK-1a, S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase alpha-1, p90S6K
Note
For research use only.
Knockdown of AMPKα2 impairs epithelial‑mesenchymal transition in rat renal tubular epithelial cells by downregulating ETS1 and RPS6KA1., PMID:33173986
Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal., PMID:33228180
TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways., PMID:33260349
Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice., PMID:33813082
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype., PMID:33911076
Dynamic Control of Signaling by Phosphorylation of PDZ Binding Motifs., PMID:34014523
Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer., PMID:34021083
MicroRNA-486-5p Suppresses Lung Cancer via Downregulating mTOR Signaling In Vitro and In Vivo., PMID:34094949
Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice., PMID:34099716
Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression., PMID:34101546
In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1., PMID:34191518
A role for translational regulation by S6 kinase and a downstream target in inflammatory pain., PMID:34355805
Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer., PMID:34373442
Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling., PMID:34504181
Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis., PMID:34506767
The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line., PMID:34638542
ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway., PMID:34861246
RSK1 SUMOylation is required for KSHV lytic replication., PMID:34871326
Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways., PMID:34872976
RSK-Mediated Non-canonical Activation of EphA2 by Tamoxifen., PMID:35110502
Altered gene expression and PTSD symptom dimensions in World Trade Center responders., PMID:35177824
Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma., PMID:35417913
Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study., PMID:35442150
DNA methylation mediates the genetic variants on ticagrelor major metabolite elimination and platelet function recovery after ticagrelor discontinuation., PMID:35574651
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis., PMID:35737463
A novel gene signature derived from the CXC subfamily of chemokine receptors predicts the prognosis and immune infiltration of patients with lung adenocarcinoma., PMID:36254009
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity., PMID:36398408
Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach., PMID:36497123
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma., PMID:36803362
The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia., PMID:37414921
Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses., PMID:37462338
Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells., PMID:38008592
Discovery of potential RSK1 inhibitors for cancer therapy using virtual screening, molecular docking, molecular dynamics simulation, and MM/GBSA calculations., PMID:38084766
S6K1 deficiency in tumor stroma impairs lung metastasis of melanoma in mice., PMID:38194806
Identification of RSK substrates using an analog-sensitive kinase approach., PMID:38342435
Inhibition of the RPS6KA1/FoxO1 signaling axis by hydroxycitric acid attenuates HFD-induced obesity through MCE suppression., PMID:38569293
PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway., PMID:38604253
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy., PMID:39137120
Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation of Mammary Epithelial Cells through the GPR37-mTOR-S6K1 Signaling., PMID:39177123
Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome., PMID:39210150
PPP1R14B-mediated phosphorylation enhances protein stability of RPS6KA1 to promote hepatocellular carcinoma tumorigenesis., PMID:39216602
Breast cancer promotes the expression of neurotransmitter receptor related gene groups and image simulation of prognosis model., PMID:39218304
RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin., PMID:39333927
Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis., PMID:39436906
RSK1 dependency in FLT3-ITD acute myeloid leukemia., PMID:39592591
RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data., PMID:39632509
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia., PMID:39820365
Overexpressed RPS6KA1 and its potential diagnostic value in head and neck squamous cell carcinoma., PMID:39827419
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression., PMID:40519166
For research use only. Not for human or drug use.
