Catalog No.
YHG67901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val219-Val404
Predicted molecular weight
22.80 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13950
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AML3, OSF2, RUNX2, Core-binding factor subunit alpha-1, PEA2-alpha A, CBF-alpha-1, Osteoblast-specific transcription factor 2, Oncogene AML-3, CBFA1, Runt-related transcription factor 2, PEBP2A, OSF-2, SL3-3 enhancer factor 1 alpha A subunit, PEBP2-alpha A, Acute myeloid leukemia 3 protein, Polyomavirus enhancer-binding protein 2 alpha A subunit, SL3/AKV core-binding factor alpha A subunit
Note
For research use only.
Dysregulation of miR-106a-5p/PTEN axis associated with progression and diagnostic of postmenopausal osteoporosis., PMID:40355896
Naringin Mitigates Chondrocyte Apoptosis in Osteoarthritis by Suppressing the miR-29a-3p-Bax Pathway., PMID:40358971
Gestational Exposure to Phenanthrene Induces Superfluous Fibrosis and Calcification and Metabolic Imbalance of the Placenta in Mice., PMID:40359265
BDNF alleviates senescence and enhances osteogenic differentiation in bone marrow mesenchymal stem cells via the TrkB/PI3K/AKT pathway., PMID:40367890
Stem cell-mediated bone regeneration of marine-derived fibrinolytic compound (FGFC-1) loaded carboxymethyl chitosan hydrogels., PMID:40373628
SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loop., PMID:40374976
Yoda1-Loaded Microfibrous Scaffolds Accelerate Osteogenesis through Piezo1-F-Actin Pathway-Mediated YAP Nuclear Localization and Functionalization., PMID:40377908
Ameliorative effect of GLP1 agonist on vascular calcification in normoglycemic aged rat aorta via miR34a/SIRT6/NRF2/HO-1 signalling pathway., PMID:40383222
Ellagic acid suppresses the human renal carcinoma cell migration and invasion by targeting the RUNX2/MMP1 expression., PMID:40386045
3D printed PHB-dextran-whitlockite porous construct coated with sildenafil-loaded nanofibers: a hybrid scaffold for craniofacial reconstruction., PMID:40389012
Zinc valproic acid complex promotes osteoblast differentiation and exhibits anti-osteoporotic potential., PMID:40391193
Compressive Force Inhibits Osteogenic Differentiation of Dental Follicle Stem Cells Through Biglycan/Bone Morphogenetic Protein2/Smad1 Signaling Pathway., PMID:40395190
Anti-osteoporotic effect of sitagliptin in an osteoporosis model of ovariectomized rats: role of RUNX2 and RANKL/OPG ratio., PMID:40397119
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway., PMID:40404584
A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)., PMID:40406460
Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation., PMID:40410897
Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations., PMID:40411668
7-Hydroxyflavone Mitigates Osteoporosis Via Key Signaling Pathways in a Dexamethasone-induced Rat Model., PMID:40415321
Metformin-Enhanced Secretome from Periodontal Ligament Stem Cells Promotes Functional Recovery in an Inflamed Periodontal Model: In Vitro Study., PMID:40422841
Capsaicin counteracts dexamethasone-induced osteoporosis and metabolic disturbances in rats: role of AMPK/SIRT1/β-catenin/RUNX2 pathway., PMID:40425907
Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone., PMID:40427572
Investigating the Associations Between Hmga2 Overexpression, R-Loop Reduction, and Bone Loss in Aging Mice., PMID:40428778
Incorporation of Zinc Oxide Nanoparticles Biosynthesized from Epimedium brevicornum Maxim. into PCL Nanofibers to Enhance Osteogenic Differentiation of Periodontal Ligament Stem Cells., PMID:40429032
In Silico Screening and Identification of Functional Peptides from Yak Bone Collagen Hydrolysates: Antioxidant and Osteoblastic Activities., PMID:40429715
GDF11 Alleviates Vascular Calcification in VitD3-Overloaded Mice Through Inhibition of Inflammatory NF-κB Signal., PMID:40432427
Fibroblast growth factor 2 stimulates differentiation of mechanically-stressed human periodontal ligament fibroblasts into cementoblasts., PMID:40434329
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis., PMID:40435818
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway., PMID:40436074
The people behind the papers - Brian Eames., PMID:40440100
Chondrocyte maturation bridges two cross-inhibitory subnetworks of the skeletal cell gene regulatory network., PMID:40440101
RUNX2 is essential for maintaining synchondrosis chondrocytes and cranial base growth., PMID:40442075
Geraniin Promotes Osteoblast Proliferation, Bone Formation, and Autophagy by Regulating the PI3K/Akt/mTOR Cascade to Improve Glucocorticoid-Induced Osteoporosis., PMID:40442527
A-485 alleviates postmenopausal osteoporosis by activating GLUD1 deacetylation through the SENP1-Sirt3 signal pathway., PMID:40442713
Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis., PMID:40442730
Phytochemical Properties of (-)-Epicatechin Promotes Bone Regeneration Inducing Osteogenic Markers Expression BMP2, SPARC, and RUNX2 in Mesenchymal Stem Cells In Vitro., PMID:40444298
Targeting casein kinase 2 and ubiquitin-specific protease 7 to modulate RUNX2-mediated osteogenesis in chronic kidney disease., PMID:40447997
FTVI promotes osteogenic differentiation of bone marrow mesenchymal stem cells through LncRNA HIF1A-AS2., PMID:40448168
Isorhamnetin ameliorates ovariectomy-induced osteoporosis in female rats by regulating the receptor activator of nuclear factor kappa B ligand, osteoprotegerin, bone morphogenetic protein 2 and runt-related transcription factor 2 signaling pathway., PMID:40451839
Porphyromonas gingivalis induced DNA oxidative stress damage by iron overload to deplete CTCF expression and prevent osteogenic differentiation of periodontal ligament stem cells., PMID:40455363
Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation., PMID:40461558
Expression of Osteogenic Genes in Dental Pulp and Their Correlations in Patients with Clinically Diagnosed Irreversible Pulpitis., PMID:40464527
A comparative study of three liquid platelet concentrates on human primary osteoblast activity: an in vitro study., PMID:40465952
Knockout of the Staphylococcus aureus virulence gene sdrC promotes Myh7 expression to inhibit the progression of osteomyelitis., PMID:40471432
Activation of GLP-1 receptors enhances the osteogenic differentiation process of STRO-1-positive BMSCs., PMID:40478323
LncRNA CA13/EFTUD2/CA13 caused crossed beak by regulating the mandibular calcification in chicken., PMID:40480132
CircRNA_1809 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells through miR-370-3p., PMID:40481048
Jatrorrhizine Alleviates Calcific Aortic Valve Disease via Interfering With Glycolysis Targeting ALDOA K42 Lactylation., PMID:40485074
Gold-doped wollastonite nanohybrids enhance bone regeneration via the bone morphogenetic protein-2, SMAD1, and Runt-related transcription factor-2 signalling pathway., PMID:40487310
RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma., PMID:40498062
Repetitive Compressive Loading Downregulates Mitochondria Function and Upregulates the Cartilage Matrix Degrading Enzyme MMP-13 Through the Coactivation of NAD-Dependent Sirtuin 1 and Runx2 in Osteoarthritic Chondrocytes., PMID:40507779
For research use only. Not for human or drug use.
