Catalog No.
YHE20601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg310
Predicted molecular weight
36.83 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P37058
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.01% SKL, 5% Trehalose.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Estradiol 17-beta-dehydrogenase 2, 17-beta-hydroxysteroid dehydrogenase type 3, Testicular 17-beta-hydroxysteroid dehydrogenase, Testosterone 17-beta-dehydrogenase 3, EDH17B3, 17-beta-HSD 3, HSD17B3, Short chain dehydrogenase/reductase family 12C member 2, SDR12C2
Note
For research use only.
Expression of G-Protein-Coupled Estrogen Receptor (GPER) in Whole Testicular Tissue and Laser-Capture Microdissected Testicular Compartments of Men with Normal and Aberrant Spermatogenesis., PMID:35336747
Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis., PMID:35427877
Tributyltin inhibits development of pubertal Leydig cells in rats., PMID:35430282
Establishment of a pure culture of immature Sertoli cells by PDGFRA staining and cell sorting., PMID:35478364
Sex-dependent host-microbiome dynamics in zebrafish: Implications for toxicology and gastrointestinal physiology., PMID:35533547
Maternal cypermethrin exposure during perinatal period dysregulates gonadal steroidogenesis, gametogenesis and sperm epigenome in F1 rat offspring., PMID:35605701
In utero bisphenol AF exposure causes fetal Leydig cell dysfunction and induces multinucleated gonocytes by generating oxidative stress and reducing the SIRT1/PGC1α signals., PMID:35605789
Per1/Per2 Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice., PMID:35806403
Parental High-Fat High-Sugar Diet Intake Programming Inflammatory and Oxidative Parameters of Reproductive Health in Male Offspring., PMID:35832794
Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues., PMID:36047744
In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress., PMID:36198370
The protective effect of L-carnitine on testosterone synthesis pathway, and spermatogenesis in monosodium glutamate-induced rats., PMID:36229797
Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis., PMID:36386800
Single-cell and microarray chip analysis revealed the underlying pathogenesis of ulcerative colitis and validated model genes in diagnosis and drug response., PMID:36445533
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway., PMID:36541330
Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population., PMID:36563763
Comprehensive molecular analysis identifies eight novel variants in XY females with disorders of sex development., PMID:36617173
Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases., PMID:36768194
Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model., PMID:36922476
Edaravone alleviates methotrexate-induced testicular injury in rats: Implications on inflammation, steroidogenesis, and Akt/p53 signaling., PMID:37012866
Molecular insights underlying the adverse effects of bisphenol A on gonadal somatic cells' steroidogenic activity., PMID:37084542
Steroidogenic enzyme gene expression and testosterone production are developmentally modulated by bone morphogenetic protein receptor-1B in mouse testis., PMID:37455641
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time., PMID:37468957
Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells., PMID:37531013
Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis., PMID:37640196
Role of Long Non-coding RNA HSD17B3-AS1 in Trauma for COVID-19., PMID:37767677
Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice., PMID:37866035
Sea cucumber peptides positively regulate sexual hormones in male mice with acute exhaustive swimming: possibly through the Ca2+/PKA signaling pathway., PMID:37909356
l-valine supplementation disturbs vital molecular pathways and induces apoptosis in mouse testes., PMID:38000127
The mitochondrial protease PARL is required for spermatogenesis., PMID:38182793
Chlorothalonil as a potential endocrine disruptor in male zebrafish (Danio rerio): Impact on the hypothalamus-pituitary-gonad axis and sperm quality., PMID:38340991
Nine-Gene Prognostic Signature Related to Gut Microflora for Predicting the Survival in Gastric Cancer Patients., PMID:38454241
Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression., PMID:38590960
The corrective role of superparamagnetic iron oxide nanoparticles for the genes controlling hypothalamus-pituitary-testis-axis in male obesity-associated secondary hypogonadism., PMID:38633156
Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center., PMID:38637882
Protective effects of L-theanine and dihydromyricetin on reproductive function in male mice under heat stress., PMID:38873879
Dynamics of HSD17B3 expression in human fetal testis: implications for the role of Sertoli cells in fetal testosterone biosynthesis., PMID:39139451
Efficacy of propolis and royal jelly in attenuating cadmium-induced spermatogenesis and steroidogenesis dysregulation, causing infertility in rats., PMID:39172338
Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb., PMID:39252136
Gonadal Development and Differentiation of Hybrid F1 Line of Ctenopharyngodon idella (♀) × Squaliobarbus curriculus (♂)., PMID:39408892
Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes., PMID:39556387
Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications., PMID:39919587
Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2/Keap1/HO-1 and PPARγ signaling., PMID:40009171
Biological and therapeutic implications of sex hormone-related gene clustering in testicular cancer., PMID:40011822
Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring., PMID:40118943
Characterization of a direct role of GnRHs in the control of spermiogenesis and steroidogenesis in the small-spotted catshark Scyliorhinus canicula., PMID:40254036
Integrated lncRNA and mRNA Transcriptome Analyses of IGF1 and IGF2 Stimulated Ovaries Reveal Genes and Pathways Potentially Associated with Ovarian Development and Oocyte Maturation in Golden Pompano (Trachinotus ovatus)., PMID:40281968
Identification of fatty acid metabolism hub genes in endometriosis using integrative bioinformatics analysis., PMID:40313549
Functional Analysis of HSD17B3-Deficient Male Mice Reveals Roles for HSD17B7 and HSD17B12 in Testosterone Biosynthesis., PMID:40336300
Bisphenol Z inhibits the function of Leydig cells via upregulation of METTL3 expression in adult male rats., PMID:40398521
For research use only. Not for human or drug use.
