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Recombinant Human CD147/BSG Protein, C-His

Catalog #:   EHE14001 Specific References (100) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: Mammalian Cells
Accession: NP_940991.1
Protein length: Met1-His205
Overview

Catalog No.

EHE14001

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Met1-His205

Predicted molecular weight

23.09 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

NP_940991.1

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Hepatoma-associated antigen, BSG, HAb18G, 5F7, TCSF, OK blood group antigen, Collagenase stimulatory factor, CD147, Leukocyte activation antigen M6, Basigin, Extracellular matrix metalloproteinase inducer, EMMPRIN, Tumor cell-derived collagenase stimulatory factor

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human CD147 / BSG
  • Bioactivity
    Detects Meplazumab in indirect ELISAs.
  • Bioactivity
    Detects Gavilimomab in indirect ELISAs.
  • Bioactivity
    Detects Human CD147/BSG Antibody (4A5) in indirect ELISAs.
References

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. PMID: 32968061

The CD147-HYALURONAN Axis in Cancer. PMID: 31090215

Role of CD147 (EMMPRIN/Basigin) in Tissue Remodeling. PMID: 30768865

Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147). PMID: 32920757

[CD147: role and therapeutic targeting of a promising molecule in the treatment of cancers]. PMID: 33052094

CD147 and glioma: a meta-analysis. PMID: 28560663

CD147 in ovarian and other cancers. PMID: 23221648

CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-kappaB-Mediated Pyroptosis. PMID: 32714980

The roles of CyPA and CD147 in cardiac remodelling. PMID: 29772453

Targeted degradation of CD147 proteins in melanoma. PMID: 33197849

Repressing CD147 is a novel therapeutic strategy for malignant melanoma. PMID: 28445958

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD. PMID: 32149134

The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues. PMID: 33008593

CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma. PMID: 32727598

EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke. PMID: 32191628

The roles of CD147 in the progression of gliomas. PMID: 26414447

CD147-mediated reprogrammed glycolytic metabolism potentially induces immune escape in the tumor microenvironment (Review). PMID: 30864716

CD147 in cardiovascular disease and thrombosis. PMID: 25280014

CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. PMID: 28386553

Clinical Significance of CD147 in Children with Inflammatory Bowel Disease. PMID: 33015178

CD147: a novel modulator of inflammatory and immune disorders. PMID: 24372217

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis. PMID: 27608940

Structural insights on druggable hotspots in CD147: A bull's eye view. PMID: 30904494

Cancer-related issues of CD147. PMID: 20551248

CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. PMID: 25248362

CD147 increases mucus secretion induced by cigarette smoke in COPD. PMID: 30727993

Function of CD147 in atherosclerosis and atherothrombosis. PMID: 25604960

Hepatic CD147 knockout modulates liver steatosis and up-regulates autophagy in high-fat-diet-induced NAFLD mice. PMID: 32063360

Importance of N-glycosylation on CD147 for its biological functions. PMID: 24739808

Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease. PMID: 29419744

CD147 is a Novel Interaction Partner of Integrin alphaMbeta2 Mediating Leukocyte and Platelet Adhesion. PMID: 32252487

Downregulation of CyclophilinA/CD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness. PMID: 32775435

Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. PMID: 20345978

CD147/basigin promotes progression of malignant melanoma and other cancers. PMID: 20060267

CD147 Expressed on Memory CD4(+) T Cells Limits Th17 Responses in Patients With Rheumatoid Arthritis. PMID: 33193313

Dealing with the family: CD147 interactions with cyclophilins. PMID: 16476049

CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis. PMID: 29642635

CD147 self-regulates matrix metalloproteinase-2 release in gingival fibroblasts after coculturing with U937 monocytic cells. PMID: 31557319

Role of CD147 in regulating the RSK2/Slug/EMT pathway in diabetic foot ulcer healing. PMID: 33053534

CD147 in regulatory T cells. PMID: 23665204

CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance. PMID: 25081536

The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis. PMID: 32291412

CD147 is critical for cancer stem cell chemoresistance: what does this mean for the clinic? PMID: 23992413

CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury. PMID: 31291257

CD147 as an alternative binding site for the spike protein on the surface of SARS-CoV-2. PMID: 33336782

The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis. PMID: 33054815

CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway. PMID: 30600459

Tumor-stroma interaction increases CD147 expression in neoplastic B lymphocytes in chronic lymphocytic leukemia. PMID: 32007924

CD147 immunoglobulin superfamily receptor function and role in pathology. PMID: 17945211

Correlation between serum CD147 and carotid intraplaque hemorrhage. PMID: 30440140

Transmembrane Protease Serine 11B Modulates Lactate Transport Through SLC16A1 in Pancreatic Ductal Adenocarcinoma-A Functional Link to Phenotype Heterogeneity., PMID:40508207

Correlation between ultrasound measurements and the expression of Her-2 and CD147 in breast cancer., PMID:40385050

Serum EMMPRIN/CD147 promotes the lung pre-metastatic niche in a D2A1 mammary carcinoma mouse model., PMID:40370456

CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway., PMID:40319830

CD147 regulates the Rap1 signaling pathway to promote proliferation, migration, and invasion, and inhibit apoptosis in colorectal cancer cells., PMID:40254691

Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial., PMID:40222976

Phillyrin from Forsythia suspensa suppresses the proliferation, angiogenesis, and metastasis of colorectal cancer via targeting CD147., PMID:40210179

CD147-CAR-NK cell therapy shows minimal toxicities in human CD147 transgenic mouse model with solid tumors., PMID:40160933

EMMPRIN Correlated with β-CATENIN in Various t Stages of Colorectal Adenocarcinoma., PMID:40156418

Urinary Basigin/CD147 is a useful marker of acute T cell-mediated rejection in kidney transplant recipients., PMID:40125925

CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells., PMID:40104175

3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways., PMID:40099866

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II., PMID:40075856

An Anti-CD147 Antibody-Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey., PMID:39985225

Cyclophilin-CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8., PMID:39963132

iPSC-derived human cortical organoids display profound alterations of cellular homeostasis following SARS-CoV-2 infection and Spike protein exposure., PMID:39950320

In vitro expression of genes encoding HIF1α, VEGFA, PGE2 synthases, and PGE2 receptors in feline oral squamous cell carcinoma., PMID:39930728

PPIA enhances cell growth and metastasis through CD147 in oral cancer., PMID:39921142

Early Use of Liraglutide for the Treatment of Acute COVID-19 Infection: An Open-Label Single-Center Phase II Safety Study with Biomarker Profiling., PMID:39846709

CD147 mitochondria translocation induced airway remodeling in asthmatic mouse models by regulating M2 macrophage polarization via ANT1-mediated mitophagy., PMID:39740799

Basigin in cerebrovascular diseases: Roles, mechanisms, and therapeutic target potential., PMID:39734038

RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147., PMID:39716463

The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal., PMID:39714986

Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions., PMID:39658753

Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway., PMID:39627812

[Analysis of Endogenous Metabolite Transporters for the Development of Novel Pharmaceutical Therapies and Drug Targets]., PMID:39617467

Disruption of the Physical Interaction Between Carbonic Anhydrase IX and the Monocarboxylate Transporter 4 Impacts Lactate Transport in Breast Cancer Cells., PMID:39596062

Galectin-3 disrupts tight junctions of airway epithelial cell monolayers by inducing expression and release of matrix metalloproteinases upon influenza A infection., PMID:39569730

CD147 expression as a clinicopathological and prognostic indicator in breast cancer: a meta-analysis and bioinformatics analysis., PMID:39567919

Radioiodinated Nanobody immunoPET probe for in vivo detection of CD147 in pan-cancer., PMID:39549046

Adhesin RadD: the secret weapon of Fusobacterium nucleatum., PMID:39520704

Cyclophilin A knockdown inhibits the proliferation and metastatic ability of AGS gastric cancer stem cells by downregulating CD147/STAT3/AKT/ERK and epithelial‑mesenchymal transition., PMID:39513611

Cyclophilin A: promising target in cancer therapy., PMID:39513594

Monocarboxylate transporter dependent mechanism is involved in proliferation, migration, and invasion of human glioblastoma cell lines via activation of PI3K/Akt signaling pathway., PMID:39475905

DMF-Bimol: Counting mRNA and Protein Molecules in Single Cells with Digital Microfluidics., PMID:39428609

Expression of nuclear receptors and glucose metabolic pathway proteins in sebaceous carcinoma: Androgen receptor and monocarboxylate transporter 1 have a key role in disease progression., PMID:39421321

Engineering affinity of humanized ScFv targeting CD147 antibody: A combined approach of mCSM-AB2 and molecular dynamics simulations., PMID:39405982

Cellular and extracellular proteomic profiling of paradoxical low-flow low-gradient aortic stenosis myocardium., PMID:39355352

Effects of atorvastatin and ezetimibe on CD147, HIF-1, MMP-2 and VEGF in carotid atherosclerotic plaque under the guidance of IVUS., PMID:39348642

The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19., PMID:39273582

Metabolic Function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview., PMID:39273126

Detection of SARS-CoV-2 binding receptors and miscellaneous targets as well as mucosal surface area of the human lacrimal drainage system., PMID:39218301

The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis., PMID:39169124

Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects., PMID:39126095

Scalable process development of NK and CAR-NK expansion in a closed bioreactor., PMID:39114666

The binding of extracellular cyclophilin A to ACE2 and CD147 triggers psoriasis-like inflammation., PMID:39096717

Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues., PMID:39088116

Emergence of SARS-CoV-2 omicron variant JN.1 in Tamil Nadu, India - Clinical characteristics and novel mutations., PMID:39080396

Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide., PMID:39078594

Rabenosyn-5 suppresses non-small cell lung cancer metastasis via inhibiting CDC42 activity., PMID:39075137

Datasheet
$ 480
Product specifications
100 μg 480 1 mg 2880

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For research use only. Not for human or drug use.

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Recombinant Human CD147/BSG Protein, C-His [EHE14001]
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