Catalog No.
YHD02501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu26-Asn102
Predicted molecular weight
35.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13987
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MSK21, MAC-inhibitory protein, MEM43 antigen, MAC-IP, MIN2, MIRL, HRF20, Protectin, 1F5 antigen, MIC11, MIN3, Membrane inhibitor of reactive lysis, MACIF, 20 kDa homologous restriction factor, CD59, MIN1, CD59 glycoprotein, HRF-20, Membrane attack complex inhibition factor
Rapid Depletion of Renal Macrophages using Human CD59/Intermedilysin Cell Ablation Tool., PMID:40418671
Influence of a Very High-Molecular Weight Fucoidan from Laminaria hyperborea on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models., PMID:40137287
SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins., PMID:39945674
Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer's disease., PMID:39773760
Plasma Glycated CD59 and Gestational Diabetes Mellitus: A Systematic Review., PMID:39548720
Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study., PMID:39523332
Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59., PMID:39485618
Enhancing the Cytotoxicity and Apoptotic Efficacy of Parasporin-2-Derived Variants (Mpp46Aa1) on Cancer Cell Lines., PMID:39453191
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis., PMID:39435487
Super-resolution microscopy unveils the nanoscale organization and self-limiting clustering of CD47 in human erythrocytes., PMID:39367479
Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy., PMID:39357054
Glycated CD59 is a potential biomarker for gestational diabetes mellitus., PMID:39351537
Navigating the Complement Pathway to Optimize PNH Treatment with Pegcetacoplan and Other Currently Approved Complement Inhibitors., PMID:39273426
Downregulation of miRNA-26a by HIV-1 Enhances CD59 Expression and Packaging, Impacting Virus Susceptibility to Antibody-Dependent Complement-Mediated Lysis., PMID:39066239
Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes., PMID:38964432
Membrane topography and the overestimation of protein clustering in single molecule localisation microscopy - identification and correction., PMID:38951588
CD59 gene: 143 haplotypes of 22,718 nucleotides length by computational phasing in 113 individuals from different ethnicities., PMID:38817044
A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course., PMID:38528725
CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells., PMID:38361357
Functionalized Graphene Quantum Dots (GQDs) based Label-Free Optical Fluorescence Sensor for CD59 Antigen Detection and Cellular Bioimaging., PMID:37976023
Characterization of tigurilysin, a novel human CD59-specific cholesterol-dependent cytolysin, reveals a role for host specificity in augmenting toxin activity., PMID:37702594
The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer., PMID:37522198
Dynamics and Molecular Interactions of GPI-Anchored CD59., PMID:37505699
Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation., PMID:37239905
The utility of plasma glycated CD59 in predicting postpartum glucose intolerance: A prospective study of women diagnosed with GDM during a period of universal GDM screening., PMID:37078256
Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection., PMID:37050931
Inherited CD59 deficiency, where neurology and genetics intertwine., PMID:37045466
Structural basis for membrane attack complex inhibition by CD59., PMID:36797260
CD59 Expression in Skeletal Muscles and Its Role in Myasthenia Gravis., PMID:36396448
Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59., PMID:36359760
Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade., PMID:36271172
CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity., PMID:36206575
Optic neuritis in CD59 deficiency: an extremely rare presentation., PMID:36082655
The utility of first trimester plasma glycated CD59 (pGCD59) in predicting gestational diabetes mellitus: A prospective study of non-diabetic pregnant women in Ireland., PMID:35907507
A Splice Site Mutation Associated with Congenital CD59 Deficiency., PMID:35735736
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets., PMID:35666870
NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59., PMID:35606403
Plasma-glycated CD59 as an early biomarker for gestational diabetes mellitus: prospective cohort study protocol., PMID:35443950
HPLC-free method of synthesis of isotopically labeled deoxyfructosylated peptides., PMID:35316349
Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal Nocturnal Hemoglobinuria Explained by Proximal Complement Activation., PMID:35173033
Recurrent Blistering Skin Lesions and Reversible Monocular Abducens Paralysis in a Patient with CD59 Deficiency., PMID:35098522
The expression and clinical significance of CD59 and FLAER in Chinese adult AML patients., PMID:34935195
Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes., PMID:34524975
New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source., PMID:34440921
Levels of lymphocyte-associated regulators of complement system CD55 and CD59 are changed in schizophrenia patients., PMID:34154502
Ceramide structure dictates glycosphingolipid nanodomain assembly and function., PMID:34135326
Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals., PMID:33838053
Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition., PMID:33577603
The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa., PMID:33555391
The expression of membrane-bound complement regulatory proteins CD46, CD55 and CD59 in oral lichen planus., PMID:33529836
For research use only. Not for human or drug use.
