Catalog No.
EHA30301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly136-Asp317
Predicted molecular weight
48.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14788
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ODF, TNF-related activation-induced cytokine, Osteoclast differentiation factor, TNFSF11, TRANCE, Osteoprotegerin ligand, RANKL, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa-B ligand, CD254, OPGL
Target tolerance improvement of the immunogenicity assay developed for analysing samples from clinical trials of RGB-14, a proposed biosimilar to Prolia/Xgeva., PMID:40368321
Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial., PMID:40350430
Pamidronate regulates the osteogenic differentiation of periosteal-derived mesenchymal stem cells in congenital tibial pseudarthrosis via OPG/RANKL., PMID:40318381
MiRNA-mRNA network in osteoporotic fractures proposes the functional mechanism of hsa-miR-32-3p/TNFSF11 axis., PMID:40301936
Inhibition of RANKL is critical for accurate assessment of anti-drug antibody incidence to denosumab in clinical studies., PMID:40220951
Effect of A. paeoniifolius extracts on bone growth and osteoporosis via inhibiting RANKL-mediated pathway., PMID:40194567
The Expression Profile of the RANK/RANKL/OPG Pathway in Breast Cancer Stem Cells Isolated From Breast Cancer Cell Lines., PMID:40159409
Visualization and quantification of RANK-RANKL binding for application to disease investigations and drug discovery., PMID:40147673
Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation., PMID:40073838
Enhanced osteogenic differentiation of human periodontal ligament cells by mature osteoclasts., PMID:39993474
Alterations of bone proteins in medication-related osteonecrosis of the jaw., PMID:39972547
RANK/RANKL Signaling Pathway in Breast Development and Cancer., PMID:39821032
Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study., PMID:39809256
Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis., PMID:39804865
Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women., PMID:39787500
Sclerostin and OPG/RANK-L system take part in bone remodeling in patients with acromegaly., PMID:39741885
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment., PMID:39739069
The role of bone inflammation in the pathogenesis of maxillary sinus cyst formation., PMID:39715124
Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 versus reference denosumab in healthy males: A randomized phase I study., PMID:39700054
Causal effects of the RANK-RANKL-OPG system and scoliosis: A bidirectional 2-sample Mendelian randomization study., PMID:39686424
Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?, PMID:39684440
RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors., PMID:39662745
Biological Markers in the Gingival Crevicular Fluid Associated with External Invasive Resorption: A Split-Mouth Cross-Sectional Study., PMID:39617293
A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma., PMID:39605211
Gene Expression Modulation of Markers Involved in Bone Formation and Resorption by Bisphenol A, Bisphenol F, Bisphenol S, and Bisphenol AF., PMID:39596653
Effects of COVID-19 on bone fragility: a new perspective from osteoimmunological biomarkers., PMID:39582872
In silicon desinging of RANKL-targeting vaccine for protection of osteoporosis based on the epitope of Denosumab., PMID:39580862
The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis., PMID:39578819
Elucidating common biomarkers and pathways of osteoporosis and aortic valve calcification: insights into new therapeutic targets., PMID:39537712
The Effect of Osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) on Aortic Valve Calcified., PMID:39537225
PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein., PMID:39536935
The effect of cold atmospheric plasma on viability of osteoblasts and expression of RANKL and OPG genes in medium with bisphosphonates., PMID:39506017
Interaction between polymorphisms in TNF-⍺ and RANKL genes is associated with the development of persistent apical periodontitis, in Brazilian subjects., PMID:39426312
Interactions of the Osteokines, Glucose/Insulin System and Vascular Risk Networks in Patients With Newly Diagnosed Type 2 Diabetes (VNDS 15)., PMID:39393014
A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression., PMID:39389988
Aberrant NSUN2-mediated m5C modification of exosomal LncRNA MALAT1 induced RANKL-mediated bone destruction in multiple myeloma., PMID:39358426
Vertebral marrow fat fraction is associated with circulating RANKL in postmenopausal females., PMID:39351524
Potential of combined red and near-infrared photobiomodulation to mitigate pro-osteoclastic and inflammatory gene expression in human mandibular osteogenic cells., PMID:39349883
HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin., PMID:39338991
Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe COVID-19., PMID:39333916
Integrated bioinformatic analysis of protein landscape in gingival crevicular fluid unveils sequential bioprocess in orthodontic tooth movement., PMID:39307846
Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells., PMID:39289624
RANK-RANKL-OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives., PMID:39273141
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients., PMID:39240628
PTHrP participates in the bone destruction of middle ear cholesteatoma via promoting macrophage differentiation into osteoclasts induced by RANKL., PMID:39174879
α-IRAK-4 Suppresses the Activation of RANK/RANKL Pathway on Macrophages Exposed to Endodontic Microorganisms., PMID:39126003
Targeting BRD4 to attenuate RANKL-induced osteoclast activation and bone erosion in rheumatoid arthritis., PMID:39110281
The Role of Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Ratio in Synovial Fluid as a Potential Marker for Periprosthetic Osteolysis Following Total Ankle Arthroplasty., PMID:39092303
Genetic Variants of the Receptor Activator Nuclear of κB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case-Control Study., PMID:39062686
Interleukin-18 binding protein regulates mast cell activation and mast cell induced osteoclastogenesis of rheumatoid arthritis., PMID:39058477
For research use only. Not for human or drug use.
