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Research Grade Zolbetuximab

Catalog #:   DHF19801 Specific References (65) DATASHEET
Host species: Chimeric
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHF19801

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Claudin-18, CLDN18

Concentration

3.3 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P56856

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Claudin 18.2, GC-182, IMAB-362, IMAB362, Claudiximab, CAS: 1496553-00-4

Clone ID

Zolbetuximab

Data Image
  • SDS-PAGE
    SDS PAGE for Zolbetuximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

1,Characterization of zolbetuximab in pancreatic cancer models,OncoImmunology,Volume 8, 2019 - Issue 1 , https://doi.org/10.1080/2162402X.2018.1523096

2,Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer, J Hematol Oncol. 2017 May 12;10(1):105. doi: 10.1186/s13045-017-0473-4.

3,Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma,https://doi.org/10.1093/jjco/hyz068

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study, PMID: 31240302

Characterization of zolbetuximab in pancreatic cancer models, PMID: 30546962

A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer, PMID: 29936063

Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer, PMID: 32410803

Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer, PMID: 28494772

Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma, PMID: 31087075

Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms, PMID: 23900716

FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma, PMID: 33610734

Patient-reported outcomes from the phase II FAST trial of zolbetuximab plus EOX compared to EOX alone as first-line treatment of patients with metastatic CLDN18.2+ gastroesophageal adenocarcinoma, PMID: 33755863

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation, PMID: 32499871

Claudin 18.2-a FAST-moving target in gastric cancer?, PMID: 33677015

Colitis-associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: implications for claudin 18.2 monoclonal antibody therapy, PMID: 33590909

Antibody Improves Survival in Gastric Cancer, PMID: 27297550

Peptide microarrays enable rapid mimotope optimization for pharmacokinetic analysis of the novel therapeutic antibody IMAB362, PMID: 24497417

Navigating the clinical challenges of zolbetuximab in patients with claudin positive advanced gastric cancer., PMID:40466467

Guidelines of Onkopedia: What is new? Esophageal Cancer., PMID:40451170

Zolbetuximab-clzb: Targeting Claudin 18.2 in Advanced Gastric and Gastroesophageal Adenocarcinoma., PMID:40426305

Biomarker-Driven Approach to the Treatment of Metastatic Gastric or Gastroesophageal Adenocarcinoma., PMID:40341124

Claudin 18.2 Expression in Gastric Tumors and Other Tumor Types With Gastric Epithelium-like Differentiation., PMID:40295026

[Zolbetuximab in combination with chemotherapy in HER2-negative and CLDN 18.2-positive locally advanced unresectable or metastatic gastric or esogastric junction adenocarcinomas]., PMID:40280797

Computer-Aided Diagnostics Helps Accurately Determine Different Expression Levels of Claudin-18.2 in Gastric Cancer., PMID:40267901

Treatment Selection for Patients with HER2-Negative Metastatic Gastric Cancer Expressing Claudin 18.2 and PD-L1., PMID:40227631

CLDN18.2: a potential nanotherapeutic target for cholangiocarcinoma., PMID:40206086

Targeted Radionuclide Therapy of CLDN18.2-Positive Gastric Cancer with [131I]I-Zolbetuximab: An In Vitro and In Vivo Study., PMID:40200396

Two cases of protein-losing enteropathy induced by zolbetuximab in patients with unresectable advanced gastric cancer., PMID:40194315

Zolbetuximab-related gastritis: a case report of the patient with prolonged gastrointestinal symptoms., PMID:40178693

Future Landscape of Anti-Claudin 18.2 Antibodies in Gastric Adenocarcinoma., PMID:40136475

Advances and challenges in gastric cancer testing: the role of biomarkers., PMID:40126094

Claudin 18 (43-14A clone) expression in pancreatic ductal adenocarcinoma: Assessment of a potential clinical biomarker for zolbetuximab therapy., PMID:40117781

Expression of Claudin18.2 in metastatic lesions in peritoneum of gastric cancer., PMID:40115911

Evaluating the pharmacokinetics of zolbetuximab in gastric adenocarcinoma., PMID:40015974

Safety and Feasibility of Outpatient Zolbetuximab Administration in Community Cancer Care: A Mixed-methods Analysis., PMID:40010971

Monoclonal Antibodies in Metastatic Gastro-Esophageal Cancers: An Overview of the Latest Therapeutic Advances., PMID:39940858

Contemporary management of advanced gastric and gastroesophageal adenocarcinomas., PMID:39918299

Claudin 18.2: An attractive marker in pancreatic ductal adenocarcinoma., PMID:39850722

Claudin 18.2 Expression in 1404 Digestive Tract Adenocarcinomas Including 1175 Colorectal Carcinomas: Distinct Colorectal Carcinoma Subtypes Are Claudin 18.2 Positive., PMID:39826799

Zolbetuximab for Unresectable and Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma: A Review of Literature., PMID:39759684

Zolbetuximab (Vyloy) for gastric and gastroesophageal carcinoma., PMID:39752728

Claudins in vulvar cancer - from epithelial barrier to potential tumor-agnostic cancer therapy., PMID:39722127

Efficacy and Safety of Zolbetuximab in Gastric Cancer., PMID:39699854

[A New Molecular Targeted Agent for Gastric Cancer-The Anti-Claudin 18.2 Antibody, Zolbetuximab]., PMID:39648123

Emerging targets in gastric and pancreatic cancer: Focus on claudin 18.2., PMID:39637967

First-line treatment with zolbetuximab plus CAPOX for ClDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a cost-effectiveness analysis., PMID:39582898

[Claudine 18.2: A new therapeutic target in digestive cancers]., PMID:39516118

Immune checkpoint inhibitors in advanced gastroesophageal adenocarcinoma: a series of patient-level meta-analyses in different programmed death-ligand 1 subgroups., PMID:39426081

Expression of claudin 18.2 in poorly cohesive carcinoma and its association with clinicopathologic parameters in East Asian patients., PMID:39368365

Targeted and combination immunotherapies using biologics for gastric cancer: the state-of-the-art., PMID:39315517

Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets., PMID:39313274

Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review)., PMID:39301632

NEJM at ESMO - Zolbetuximab in Gastric or Gastroesophageal Junction Adenocarcinoma., PMID:39282947

Zolbetuximab in Gastric or Gastroesophageal Junction Adenocarcinoma., PMID:39282934

Targeting Claudin-18.2 for cancer therapy: updates from 2024 ASCO annual meeting., PMID:39183320

Variability in morphology and immunohistochemistry of Crohn's disease-associated small bowel neoplasms: implications of Claudin 18 and Cadherin 17 expression for tumor-targeted immunotherapies., PMID:39164422

[What's new in gastric cancer?]., PMID:39146748

Health-related quality of life in patients with CLDN18.2-positive, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma: results from the SPOTLIGHT and GLOW clinical trials., PMID:39146670

A novel highly sensitive inner filter effect-based fluorescence immunoassay with quantum dots for bioanalysis of zolbetuximab, a monoclonal antibody used for immunotherapy of gastric and gastroesophageal junction adenocarcinoma., PMID:39114008

Claudin-18.2 Immunohistochemical Evaluation in Gastric and Gastroesophageal Junction Adenocarcinomas to Direct Targeted Therapy: A Practical Approach., PMID:39098518

The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer., PMID:39095563

Zolbetuximab on the SPOTLIGHT-a light spot?, PMID:38988087

Zolbetuximab: First Approval., PMID:38967717

Global prevalence of claudin 18 isoform 2 in tumors of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma., PMID:38954176

Preparation of Radiolabeled Zolbetuximab Targeting CLDN18.2 and Its Preliminary Evaluation for Potential Clinical Applications., PMID:38949095

Datasheet

Document Download

Research Grade Zolbetuximab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Zolbetuximab [DHF19801]
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