Catalog No.
YHJ97201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser273-Ser477
Predicted molecular weight
26.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NY61
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHE1, AATF, DED, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, Protein AATF
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma., PMID:40436899
Molecular insights unlocking therapeutic potential for multiple myeloma and bone disease management., PMID:39695699
CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma., PMID:39428382
Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor., PMID:39408701
Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers., PMID:39325823
TACE inhibition: a promising therapeutic intervention against AATF-mediated steatohepatitis to hepatocarcinogenesis., PMID:38558505
Putting the Ducks in a Row: Development of a Duck-assisted Green Care Intervention for Persons with Traumatic Brain Injury., PMID:38232125
Prenatal diagnosis and perinatal findings of 17q12 microdeletion encompassing HNF1B in a fetus with bilateral hyperechogenic kidneys on fetal ultrasound and mild renal abnormality after birth, and a review of the literature of prenatal diagnosis of 17q12 microdeletion., PMID:38216274
Apoptosis antagonizing transcription factor-mediated liver damage and inflammation to cancer: Therapeutic intervention by curcumin in experimental metabolic dysfunction associated steatohepatitis-hepatocellular carcinoma., PMID:37942831
HAX1 is a novel binding partner of Che-1/AATF. Implications in oxidative stress cell response., PMID:37742722
AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation., PMID:37435061
Topical Delivery of Atraric Acid Derived from Stereocaulon japonicum with Enhanced Skin Permeation and Hair Regrowth Activity for Androgenic Alopecia., PMID:36839662
Exome and Sputum Microbiota as Predictive Markers of Frequent Exacerbations in Chronic Obstructive Pulmonary Disease., PMID:36291689
The Oncogenic and Immunological Roles of Apoptosis Antagonistic Transcription Factors in Human Tumors: A Pan-Cancer Analysis., PMID:36275893
NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma., PMID:36183976
AATF Competitively Interacts with Nuclear AIF and Inhibits Parthanatos of Neurons in dMCAO/R and OGD/R Models., PMID:36058992
AATF/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma., PMID:35929179
FIP-fve Stimulates Cell Proliferation and Enhances IL-2 Release by Activating MAP2K3/p38α (MAPK14) Signaling Pathway in Jurkat E6-1 Cells., PMID:35614983
AATF is Overexpressed in Human Bladder Cancer and Regulates Chemo-Sensitivity Through Survivin., PMID:35002255
AATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling., PMID:34785906
STING nuclear partners contribute to innate immune signaling responses., PMID:34541469
CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity., PMID:34266450
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner., PMID:33420414
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma., PMID:33186461
Emerging roles of AATF: Checkpoint signaling and beyond., PMID:33145763
Genetic determinants of ammonia-induced acute lung injury in mice., PMID:33050709
AATF/Che-1-An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis., PMID:32587828
Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development., PMID:32579612
Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription., PMID:32421830
AATF and SMARCA2 are associated with thyroid volume in Hashimoto's thyroiditis patients., PMID:32019955
Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma., PMID:31545418
A protein-RNA interaction atlas of the ribosome biogenesis factor AATF., PMID:31363146
Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide., PMID:31152681
Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis., PMID:30770218
MicroRNA-663 antagonizes apoptosis antagonizing transcription factor to induce apoptosis in epithelial cells., PMID:30610504
A Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma., PMID:30394550
Tumorigenic PVT-1 gene locus is governed by miR-2909 RNomics., PMID:30318596
Human cellular mitochondrial remodelling is governed by miR-2909 RNomics., PMID:30252847
Identification of the RNA polymerase I-RNA interactome., PMID:30169671
Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress., PMID:30165671
Che-1 inhibits oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis associated with inhibition of the p53-mediated proapoptotic signaling pathway., PMID:30001227
A new baby in the c-Myc-directed transcriptional machinery: Che-1/AATF., PMID:29943642
Identification of potential genes and miRNAs associated with sepsis based on microarray analysis., PMID:29512785
Che-1 attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by upregulation of Nrf2 signaling., PMID:29509260
Che-1 is targeted by c-Myc to sustain proliferation in pre-B-cell acute lymphoblastic leukemia., PMID:29367285
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer., PMID:29321668
Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes., PMID:29232376
Transcriptional correlates of memory maintenance following long-term sensitization of Aplysia californica., PMID:28916625
miR-2909 regulates ISGylation system via STAT1 signalling through negative regulation of SOCS3 in prostate cancer., PMID:28622443
Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization., PMID:28214471
For research use only. Not for human or drug use.
