Catalog No.
YHJ96901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro559-Leu747
Predicted molecular weight
23.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92800
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone-lysine N-methyltransferase EZH1, ENX-2, Enhancer of zeste homolog 1, KIAA0388, EZH1
EZH1 deficiency promotes ferroptosis resistance by activating NRF2 in sepsis-associated liver injury., PMID:40490833
H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma., PMID:40287708
Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirs ex vivo., PMID:40276229
Pharmacokinetics, metabolism, and excretion of [14C]-valemetostat in healthy male participants, and in vitro plasma protein binding., PMID:40208327
Epigenetic enhancement of adoptive T cell immunotherapy., PMID:40068593
Genome-wide association analysis identified the involvement of MRPS22 in the regulation of Muscovy duck broodiness., PMID:40068571
Toll-Interacting Protein Down-Regulation by Cigarette Smoke Exposure Impairs Human Lung Defense against Influenza A Virus Infection., PMID:40056974
Polycomb repressive complex 2 (PRC2) pathway's role in cancer cell plasticity and drug resistance., PMID:40048009
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models., PMID:39983725
EZH1-DNMT1 axis inhibits the expression of TFPI2 to promote osteogenic differentiation of periosteum-derived stem cells and accelerate fracture repair., PMID:39892329
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells., PMID:39825205
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells., PMID:39799569
Oncogenic activation of PI K3 CA in cancers: Emerging targeted therapies in precision oncology., PMID:39717717
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice., PMID:39511641
Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors., PMID:39495444
Valemetostat monotherapy in patients with relapsed or refractory non-Hodgkin lymphoma: a first-in-human, multicentre, open-label, single-arm, phase 1 study., PMID:39486432
PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability., PMID:39433902
Epigenetic therapies targeting histone lysine methylation: complex mechanisms and clinical challenges., PMID:39403928
A novel EZH1/2 dual inhibitor inhibits GCB DLBCL through cell cycle regulation and M2 tumor-associated macrophage polarization., PMID:39303914
Epigenetics enters the stage in vascular malformations., PMID:39087470
Dual-target EZH2 inhibitor: latest advances in medicinal chemistry., PMID:39082677
A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer., PMID:38940666
Whole-exome Sequencing of Atypical Parathyroid Tumors Detects Novel and Common Genes Linked to Parathyroid Tumorigenesis., PMID:38940486
Biallelic loss-of-function variants of EZH1 cause a novel developmental disorder with central precocious puberty., PMID:38814056
Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models., PMID:38781032
H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation., PMID:38698061
Unlocking adult T-cell leukemia/lymphoma's epigenetic secrets: delving into the mechanism and impact of EZH1/2 inhibition., PMID:38606590
Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium., PMID:38580969
Clinical Significance of Upregulation of EZH1 Expression in Hepatocellular Carcinoma Tissues., PMID:38554427
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells., PMID:38534772
Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos., PMID:38529784
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression., PMID:38439966
MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors., PMID:38433910
Mechanisms of action and resistance in histone methylation-targeted therapy., PMID:38383791
The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma., PMID:38309675
Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma., PMID:38201285
FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia., PMID:38182819
EZH1/2 alteration as a potential biomarker for immune checkpoint inhibitors across multiple cancer types., PMID:38102713
MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de‑methylases., PMID:37921060
EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes., PMID:37747726
Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects., PMID:37705321
WSB1 Involvement in Prostate Cancer Progression., PMID:37628609
Epigenetic Regulation of the Expression of T Cell Stimulatory and Inhibitory Factors by Histone H3 Lysine Modification Enzymes and Its Prognostic Roles in Glioblastoma., PMID:37605497
Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation., PMID:37593409
A Combination of BRAF and EZH1/SPOP/ZNF148 Three-Gene Mutational Classifier Improves Benign Call Rate in Indeterminate Thyroid Nodules., PMID:37572175
[EZH inhibitors in lymphoma therapy]., PMID:37544728
Targeting EZH2 in SMARCB1-deficient sarcomas: Advances and opportunities to potentiate the efficacy of EZH2 inhibitors., PMID:37541451
Histone bivalency regulates the timing of cerebellar granule cell development., PMID:37491148
Ezh2-dependent methylation in oral epithelia promotes secondary palatogenesis., PMID:37435868
Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders., PMID:37433783
For research use only. Not for human or drug use.
