Catalog No.
YMJ95901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Asn423-Arg565
Predicted molecular weight
19.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q80XJ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RING-type E3 ubiquitin transferase RNF168, RNF168, E3 ubiquitin-protein ligase RNF168, hRNF168, RING finger protein 168
Dynamics of chromatin factors RSF1, CENPS and CENPX at DNA damage sites., PMID:40450933
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance., PMID:40229270
The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease., PMID:39996778
Translational regulation of SND1 governs endothelial homeostasis during stress., PMID:39895626
LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1., PMID:39695078
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling., PMID:39445802
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168., PMID:39394267
A Site-Specific Click Chemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168., PMID:39377639
Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63-Polyubiquitylated Linker Histone H1., PMID:39363740
USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency., PMID:39261935
H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition., PMID:39253432
Phosphorylation of the DNA damage repair factor 53BP1 by ATM kinase controls neurodevelopmental programs in cortical brain organoids., PMID:39226322
RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells., PMID:39004272
Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers., PMID:38990837
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease., PMID:38985307
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair., PMID:38968116
A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells., PMID:38943334
UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168., PMID:38866770
Evolved histone tail regulates 53BP1 recruitment at damaged chromatin., PMID:38821984
Topology of Ubiquitin Chains in the Chromatosomal Environment of the E3 Ubiquitin Ligase RNF168., PMID:38462450
The role of TAOK3 in cancer progression and development as a prognostic marker: A pan-cancer analysis study., PMID:38318319
Mechanisms of RNF168 nucleosome recognition and ubiquitylation., PMID:38242129
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress., PMID:38232606
RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy., PMID:37760968
KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function., PMID:37712615
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair., PMID:37503842
UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair., PMID:37451480
SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer., PMID:37350666
Ubiquitin E3 ligases in cancer: somatic mutation and amplification., PMID:37081755
Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis., PMID:36944318
RAS and PP2A activities converge on epigenetic gene regulation., PMID:36858798
Emerging Roles of RNF168 in Tumor Progression., PMID:36771081
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon., PMID:36720220
DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation., PMID:36642815
A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62., PMID:36331508
Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer., PMID:35797901
Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease., PMID:35224690
MRE11 and UBR5 Co-Operate to Suppress RNF168-Mediated Fusion of Dysfunctional Telomeres., PMID:34881184
RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination., PMID:34873829
Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites., PMID:34726323
RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair., PMID:34706224
Enrichment of rare variants in E3 ubiquitin ligase genes in Early onset Parkinson's disease., PMID:34544586
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining., PMID:34481157
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage., PMID:34408138
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination., PMID:34321663
A simple microscopy setup for visualizing cellular responses to DNA damage at particle accelerator facilities., PMID:34267233
Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance., PMID:34188037
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461., PMID:33963218
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms., PMID:33867526
RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression., PMID:33865221
For research use only. Not for human or drug use.
