Catalog No.
YHJ91701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr76-Pro317
Predicted molecular weight
28.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6Q6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Osteoclast differentiation factor receptor, Receptor activator of NF-KB, TNFRSF11A, ODFR, Tumor necrosis factor receptor superfamily member 11A, CD265, RANK
[Clinical and genetic characteristics of osteopetrosis in children]., PMID:40462430
Duplications within exon 1 of TNFRSF11A encoding receptor activator of nuclear factor-kappa B (RANK) are associated with tendon avulsion., PMID:40222603
The Expression Profile of the RANK/RANKL/OPG Pathway in Breast Cancer Stem Cells Isolated From Breast Cancer Cell Lines., PMID:40159409
RANK/RANKL Signaling Pathway in Breast Development and Cancer., PMID:39821032
Causal effects of the RANK-RANKL-OPG system and scoliosis: A bidirectional 2-sample Mendelian randomization study., PMID:39686424
RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors., PMID:39662745
The Effect of Osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) on Aortic Valve Calcified., PMID:39537225
RANK-RANKL-OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives., PMID:39273141
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients., PMID:39240628
B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation., PMID:39198400
α-IRAK-4 Suppresses the Activation of RANK/RANKL Pathway on Macrophages Exposed to Endodontic Microorganisms., PMID:39126003
RANKL/RANK signaling recruits Tregs via the CCL20-CCR6 pathway and promotes stemness and metastasis in colorectal cancer., PMID:38902257
Correlation of RANK and RANKL with mammographic density in primary breast cancer patients., PMID:38836929
Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients., PMID:38230588
Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer., PMID:37451269
Denosumab Attenuates Glucolipotoxicity-Induced β-Cell Dysfunction and Apoptosis by Attenuating RANK/RANKL Signals., PMID:37373436
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death., PMID:36801923
Early identification of a 12-bp tandem duplication in TNFRSF11A encoding receptor activator of nuclear factor-kappa B (RANK): Clinical characterization and response to bisphosphonate therapy., PMID:36740137
ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption., PMID:36634847
The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies., PMID:36589815
Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial., PMID:36535121
Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27)., PMID:36520195
RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages., PMID:35463988
Association Between Serum Selenium Concentration and OPG/RANKL/RANK Axis in Patients with Arterial Hypertension., PMID:35412194
The relationship between chemerin, bone metabolism, the RANKL/RANK/OPG system, and bone mineral density in girls with anorexia nervosa., PMID:35119086
Molecular Mechanisms Leading from Periodontal Disease to Cancer., PMID:35055157
Vertebral osteomyelitis is characterised by increased RANK/OPG and RANKL/OPG expression ratios in vertebral bodies and intervertebral discs., PMID:34846723
The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders., PMID:34830256
RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)., PMID:34828291
The RANKL/RANK system in female reproductive organ tumors: A preclinical and clinical overview., PMID:34435475
The Relationship between Serum and Gene Expression Levels of RANK, RANKL and Osteoprotegerin Inflammatory Pathway with Unstable Angina: A Case-control Study., PMID:34418901
Genetic variations in tumor ecrosis factor related apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt., PMID:34275891
A novel mutation in TNFRSF11A gene causes pediatric osteopetrosis: case report., PMID:34049530
Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer., PMID:33962883
RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis., PMID:33795653
RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer., PMID:33785053
OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men., PMID:33773583
Immunoexpression of RANK, RANKL and OPG in sporadic odontogenic keratocysts and their potential association with recurrence., PMID:33768738
Insertion Mutation in Tnfrsf11a Causes a Paget's Disease-Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice., PMID:33724536
Human apoptosis antibody array-membranes studying the apoptotic effect of marine bacterial exopolysaccharides in HepG2 cells., PMID:33723130
Bone anti-resorptive effects of coumarins on RANKL downstream cellular signaling: a systematic review of the literature., PMID:33556550
RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells., PMID:33552088
Expanding the phenotypic spectrum of TNFRSF11A-associated dysosteosclerosis: a case with intracranial extramedullary hematopoiesis., PMID:33402699
Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women., PMID:33376557
TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients., PMID:33269432
The Non-Bone-Related Role of RANK/RANKL Signaling in Cancer., PMID:33119864
Structure of a DNA G-Quadruplex Related to Osteoporosis with a G-A Bulge Forming a Pseudo-loop., PMID:33096904
Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia., PMID:33075129
The third case of TNFRSF11A-associated dysosteosclerosis with a mutation producing elongating proteins., PMID:33037392
Association of a single nucleotide polymorphism of RANK gene with blood pressure in Spanish women., PMID:33019425
For research use only. Not for human or drug use.
