Catalog No.
YHJ90901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys253
Predicted molecular weight
31.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y696
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Chloride intracellular channel protein 4, CLIC4, Intracellular chloride ion channel protein p64H1
A framework for studying multi-omic risk factors and their interplay: application to coronary artery disease., PMID:40236413
Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities., PMID:40235733
Biophysical characterization of anion channels in mitochondrion-endoplasmic-reticulum contact sites., PMID:40188360
A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression., PMID:40114969
Mendelian randomization analysis and molecular mechanism study of childhood asthma and obstructive sleep apnea., PMID:40029375
Functional insight into East Asian-specific genetic risk loci for Alzheimer's disease., PMID:39991798
Proteome signature for differential diagnosis of patients with bilateral lung infiltrates., PMID:39963163
Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities., PMID:39896666
PCLAF-DREAM drives alveolar cell plasticity for lung regeneration., PMID:39448571
Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer's disease: CLIC4 protein expression and tau protein hyperphosphorylation., PMID:39181373
Chloride intracellular channel 4 participates in the regulation of lipopolysaccharide-induced inflammatory responses in human bronchial epithelial cells., PMID:39029565
CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions., PMID:38727794
Retrograde AAV-mediated gene modulation reveals chloride intracellular channel proteins as potent regulators of retinal ganglion cell death., PMID:38714284
Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways., PMID:38609844
RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4., PMID:38390782
The cross talk between type II diabetic microenvironment and the regenerative capacities of human adipose tissue-derived pericytes: a promising cell therapy., PMID:38331889
In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins., PMID:37759794
Deciphering the implications of mitophagy-related signatures in clinical outcomes and microenvironment heterogeneity of clear cell renal cell carcinoma., PMID:37689589
Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis., PMID:37458329
CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA., PMID:37317855
Transcriptome Profiling of Prostate Cancer, Considering Risk Groups and the TMPRSS2-ERG Molecular Subtype., PMID:37298233
Application of transcriptomics and proteomics in pulmonary arterial hypertension., PMID:37195212
The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma., PMID:37026609
Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein., PMID:36659928
Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma., PMID:36291816
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection., PMID:36269835
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension., PMID:36264759
Chloride Intracellular Channel Proteins (CLICs) and Malignant Tumor Progression: A Focus on the Preventive Role of CLIC2 in Invasion and Metastasis., PMID:36230813
Nuclear localisation sequences of chloride intracellular channels 1 and 4 facilitate nuclear import via interactions with import mediator importin-α: An empirical and theoretical perspective., PMID:36175369
The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells., PMID:35863434
Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol., PMID:35732323
Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence., PMID:35727842
N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability., PMID:35397614
Neutrophil-derived extracellular vesicles induce endothelial inflammation and damage through the transfer of miRNAs., PMID:35378380
Bovine Peripheral Blood Derived Lymphocyte Proteome and Secretome Show Divergent Reaction of Bovine Immune Phenotypes after Stimulation with Pokeweed Mitogen., PMID:35225986
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation., PMID:35159339
Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis., PMID:35081862
Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function., PMID:35078024
Targeted proteomic analysis dataset of archival core human kidney biopsies to investigate the biology of hypertensive nephropathy., PMID:35071703
Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration., PMID:35042858
Comparative kinetic analysis of ascorbate (Vitamin-C) recycling dehydroascorbate reductases from plants and humans., PMID:35007834
Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol., PMID:34839533
Detection of Cells Displaying High Expression of CLIC4 in Tumor Tissue of Patients With Colorectal Cancer., PMID:34697147
Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats., PMID:34363182
Circ-USP9X Inhibition Reduces Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury via the microRNA 599/Chloride Intracellular Channel 4 Axis., PMID:34269702
Transcriptome analysis of chloride intracellular channel knockdown in Drosophila identifies oxidation-reduction function as possible mechanism of altered sensitivity to ethanol sedation., PMID:34228751
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function., PMID:33879602
Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis., PMID:33822672
Effects of CLIC4 on Fucoxanthinol-Induced Apoptosis in Human Colorectal Cancer Cells., PMID:33703973
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis., PMID:33585442
For research use only. Not for human or drug use.
