Catalog No.
YHJ90501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe64-Leu249
Predicted molecular weight
22.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y624
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PAM-1, JAM1, Platelet F11 receptor, JCAM, JAM-A, F11R, Junctional adhesion molecule A, Junctional adhesion molecule 1, CD321, Platelet adhesion molecule 1, JAM-1
Upstream transcription factor 1 suppresses laryngeal squamous cell carcinoma progression through transcriptional activation of junctional adhesion molecule 3., PMID:40071730
High-adhesion ovarian cancer cell resistance to ferroptosis: The activation of NRF2/FSP1 pathway by junctional adhesion molecule JAM3., PMID:39706500
SLC37A4, gene responsible for glycogen storage disease type 1b, regulates gingival epithelial barrier function via JAM1 expression., PMID:39433915
Multilayered proteomics reveals that JAM-A promotes breast cancer progression via regulation of amino acid transporter LAT1., PMID:38943512
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?, PMID:37246517
JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells., PMID:37060532
Human seminal plasma stimulates the migration of CD11c+ mononuclear phagocytes to the apical side of the colonic epithelium without altering the junctional complexes in an ex vivo human intestinal model., PMID:37033941
The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple-negative breast cancers., PMID:36782375
Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2hi osteoclast progenitors., PMID:36591261
HOXD11 upregulates JAM-A and exerts oncogenic properties via NF-κB signaling pathway in esophageal squamous cell carcinoma., PMID:36214988
LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-β., PMID:36162632
Long non-coding RNA DEPDC1-AS1 promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway., PMID:35466755
A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer., PMID:35203384
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells., PMID:34930929
The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression., PMID:34533648
MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer., PMID:34226680
Targeting the tetraspanin CD81 reduces cancer invasion and metastasis., PMID:34099563
Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation., PMID:34000305
Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients., PMID:33780157
Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury., PMID:33737554
Effect of roasted peanut allergen Ara h 3 protein on the sensitization of Caco-2 cells., PMID:33650104
HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63‑mediated tight junction molecules and p21‑mediated growth arrest., PMID:33649777
LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A., PMID:33400379
Integrative Approach to Assessing the Complex of Correlations between Indicators of Physiological Functions., PMID:33263845
Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155., PMID:33185939
Generation of Genetically RGD σ1-Modified Oncolytic Reovirus That Enhances JAM-A-Independent Infection of Tumor Cells., PMID:32907973
Tongxinluo attenuates oxygen-glucose-serum deprivation/restoration-induced endothelial barrier breakdown via peroxisome proliferator activated receptor-α/angiopoietin-like 4 pathway in high glucose-incubated human cardiac microvascular endothelial cells., PMID:32846824
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function., PMID:32673519
Effect of Rewarming on Leukocyte-Endothelial Interaction After Deep Hypothermic Preservation., PMID:32080161
Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1., PMID:31697789
Functional inhibition of F11 receptor (F11R/junctional adhesion molecule-A/JAM-A) activity by a F11R-derived peptide in breast cancer and its microenvironment., PMID:31650345
Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients., PMID:31625931
miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A., PMID:31428943
Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis., PMID:31167130
Joint detection of claudin-1 and junctional adhesion molecule-A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma., PMID:31161679
APOC3 promotes TNF-α-induced expression of JAM-1 in endothelial cell via PI3K-IKK2-p65 pathway., PMID:31004933
Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes., PMID:30948775
Alterations of Human Plasma Proteome Profile on Adaptation to High-Altitude Hypobaric Hypoxia., PMID:30908922
Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization., PMID:30874584
Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways., PMID:30834573
Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice., PMID:30745566
Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings., PMID:30458861
Natural compound Tetrocarcin-A downregulates Junctional Adhesion Molecule-A in conjunction with HER2 and inhibitor of apoptosis proteins and inhibits tumor cell growth., PMID:30312728
The Intercellular Tight Junction and Spontaneous Coronary Artery Dissection., PMID:30261968
JAM-A knockdown accelerates the proliferation and migration of human keratinocytes, and improves wound healing in rats via FAK/Erk signaling., PMID:30154481
Immunoreactivity patterns of tight junction proteins are useful for differential diagnosis of human salivary gland tumors., PMID:29955965
The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells., PMID:29751293
Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products., PMID:29102636
Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders., PMID:29066542
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF., PMID:29034528
For research use only. Not for human or drug use.
