Catalog No.
YHJ88701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His132
Predicted molecular weight
17.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y572
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RIPK3, RIP-like protein kinase 3, RIP3, Receptor-interacting serine/threonine-protein kinase 3, RIP-3, Receptor-interacting protein 3
Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis., PMID:40513868
Polymorphisms in Necroptosis Pathway Genes: Novel Prognostic Markers for Multiple Myeloma Treatment Outcomes., PMID:40508046
Distinct Types of Regulated Cell Death in Melanoma., PMID:40497999
CYPD limits HR+ mammary carcinogenesis in mice., PMID:40494873
From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases., PMID:40493155
Receptor interacting protein kinase 1 activation and triggering mesangial cells necroptosis in MRL/lpr mice model of lupus nephritis., PMID:40492666
PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis., PMID:40489618
Keratinocyte necroptosis promotes the progression of radiation-induced oral mucositis., PMID:40483488
Anti-inflammatory mechanism of the MLKL inhibitor necrosulfonamide in LPS- or poly(I:C)-induced neuroinflammation and necroptosis., PMID:40473224
Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species., PMID:40437958
Phosphoglycerate Mutase 5 Is Important Mediator for Instigating Arterial Lipid Accumulation and Aggravating Atherosclerosis., PMID:40436527
Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates., PMID:40434815
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis., PMID:40430799
Circulating RIPK3 level predicts all-cause mortality in patients on maintenance hemodialysis: a 4-year prospective cohort study., PMID:40426084
A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis., PMID:40424123
PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity., PMID:40422233
Circular RNA-OGDH Promotes PANoptosis in Diabetic Cardiomyopathy: A Novel Mechanistic Insight., PMID:40412523
Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction., PMID:40412245
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation., PMID:40408995
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway., PMID:40407231
Discovery of quinazoline derivatives as RIPK3 inhibitors that switch cell death from necroptosis to apoptosis for psoriasis treatment., PMID:40398153
Receptor-interacting protein kinase 3: A macromolecule with multiple cellular actions and its perspective in the diagnosis and treatment of heart disease., PMID:40389003
Exploring the Anticancer Potential of Lamivudine-Loaded Polymeric Nanoparticles: In Vitro Cytotoxicity, Tissue Deposition, Biochemical Impact In Vivo, and Molecular Simulations Analysis., PMID:40384113
TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling., PMID:40350054
Zn2+ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury., PMID:40348119
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal ganglion cell loss in rats., PMID:40345829
Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy., PMID:40345706
Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro., PMID:40341069
Epigenetic Inactivation of RIPK3-Dependent Necroptosis Augments Cisplatin Chemoresistance in Human Osteosarcoma., PMID:40332549
Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro., PMID:40328155
Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis., PMID:40327971
[Disulfiram alleviates cardiac hypertrophic injury by inhibiting TAK1-mediated PANoptosis]., PMID:40326066
Lactoferrin Alleviates LPS-Induced Oxidative Stress and Necroptosis in Liver by Promoting Mitophagy., PMID:40323104
Theaflavin suppresses necroptosis by attenuating RIPK1-RIPK3-MLKL signaling and mitigates cisplatin-induced kidney injury in mice., PMID:40318271
Nano-selenium alleviates tetrabromobisphenol A induced PANoptosis in carp gill tissue by inhibiting TLR4/MyD88/NF-κB pathway., PMID:40311953
The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis., PMID:40311590
Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins., PMID:40307003
RIPK1/RIPK3/MLKL Necrosome Contributes to the Sepsis-Induced Cardiorenal Necroptotic Inflammatory Injury and Mortality., PMID:40296630
Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart., PMID:40295682
Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection., PMID:40281523
Roles of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatics analysis and animal experiment verification., PMID:40274384
ZBP1 senses splicing aberration through Z-RNA to promote cell death., PMID:40267920
Neuregulin-1 prevents death from a normally lethal respiratory viral infection., PMID:40267147
Caspase-independent cell death in lung cancer: from mechanisms to clinical applications., PMID:40257494
Enhancement of reactive oxygen species metabolism by antioxidant enzyme Cu/Zn-SOD can block betanodavirus-induced necroptosis and suppress viral replication in fish cells., PMID:40254084
The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure., PMID:40249973
Oligomerised RIPK1 is the main core component of the CD95 necrosome., PMID:40240880
MLKL Inhibitor Reduces Oxidative Stress, Inflammation, and Dopaminergic Neuronal Cell Death in MPTP-Induced Parkinson's Disease Mouse Model., PMID:40229146
Necrostatin-1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice., PMID:40222051
UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity., PMID:40221399
For research use only. Not for human or drug use.
