Catalog No.
YHJ88001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser985-Ala1255
Predicted molecular weight
29.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y4H2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRS2, Insulin receptor substrate 2, IRS-2
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway., PMID:40473822
The Effect of Tff3 Deficiency on the Liver of Mice Exposed to a High-Fat Diet., PMID:40426854
The Hypoglycemic Activity of Gracilaria lemaneiformis Polysaccharide Gels Based on IR/IRS-2/PI3k/Akt/Glut4 and Glycometabolism Signaling Pathways in HepG2 Cells., PMID:40422385
The Effect and Mechanism of Regular Exercise on Improving Insulin Impedance: Based on the Perspective of Cellular and Molecular Levels., PMID:40362436
Gan-tang-yi decoction improves hepatic insulin resistance through activation of IRS2/PI3K/Akt pathway and inhibition of AGEs/RAGE pathway in cirrhotic rats., PMID:40345270
Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism., PMID:40342065
A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells., PMID:40285526
Exploration of the shared gene signatures and molecular mechanisms between cardioembolic stroke and ischemic stroke., PMID:40264650
Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease., PMID:40257057
Transcriptional Response to Fasting Studied in the Liver of Mice That Express Phosphorylation Resistant Perilipin 5., PMID:40238664
Hypoglycemic and Gut Microbiota-Modulating Effects of Pectin from Citrus aurantium "Changshanhuyou" Residue in Type 2 Diabetes Mellitus Mice., PMID:40191895
Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study., PMID:40179269
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction., PMID:40178645
Methylglyoxal-induced neuronal dysfunction: Linking diabetes to Alzheimer's disease through cytoskeletal disruption., PMID:40107340
IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions., PMID:40105689
Long non-coding RNA LINC01232 promotes malignancy of prostate cancer through regulation of miR-181a-5p/IRS2 pathway: Ki-67 protein molecular structure and function., PMID:40057086
IRS gene polymorphisms in Turkish patients with late-onset Alzheimer's disease., PMID:39954137
Insulin Receptor Substrate-2 Regulates the Secretion of Growth Factors in Response to Amino Acid Deprivation., PMID:39859555
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant., PMID:39835783
Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson's Disease., PMID:39830652
[Berberine regulates glucose and lipid metabolism via clock-controlled genes to ameliorate insulin resistance of hepatocytes]., PMID:39805783
The Glucose-Lowering Effect of Mesembryanthemum crystallinum and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats., PMID:39796627
Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats., PMID:39779784
Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer's Disease., PMID:39762668
Viscosol Treatment Ameliorates Insulin-Mediated Regulation of Dyslipidemia, Hepatic Steatosis, and Lipid Metabolism by Targeting PTP1B in Type-2 Diabetic Mice Model., PMID:39759127
Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak., PMID:39736467
Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period., PMID:39684804
Identification of lipid metabolism-related biomarkers and prognostic analysis in geriatric patients with sepsis., PMID:39616476
Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients., PMID:39614667
Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal., PMID:39585487
Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice., PMID:39574625
Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis., PMID:39566466
Prenatal choline supplementation enhances metabolic outcomes with differential impact on DNA methylation in Wistar rat offspring and dams., PMID:39547266
Highland Barley Alleviates High-Fat Diet-Induced Obesity and Liver Injury Through the IRS2/PI3K/AKT Signaling Pathway in Rats., PMID:39458511
ASPSCR1::TFE3-mediated upregulation of insulin receptor substrate 2 (IRS-2) activates PI3K/AKT signaling and promotes malignant phenotype., PMID:39419345
Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediates potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells., PMID:39395135
Crosstalk between MIR-96 and IRS/PI3K/AKT/VEGF cascade in hRPE cells; A potential target for preventing diabetic retinopathy., PMID:39348384
Distinct Genomic Expression Signatures after Low-Force Electrically Induced Exercises in Persons with Spinal Cord Injury., PMID:39337673
Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function., PMID:39305958
Comparative Effects of Tumor Necrosis Factor Alpha, Lipopolysaccharide, and Palmitate on Mitochondrial Dysfunction in Cultured 3T3-L1 Adipocytes., PMID:39269560
IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis., PMID:39253856
HMGA1 Regulates IRS2 to Promote Inflammatory Responses and Oxidative Stress Injury in MPP+-Induced cells., PMID:39244689
RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2., PMID:39232805
Physiological and pathophysiological actions of insulin in the liver., PMID:39231651
Evaluating combined effects of chronic, low-dose exposures of cadmium (CLEC) and hyperglycemia on insulin signaling dysfunction in a hepatocellular model., PMID:39191366
Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster., PMID:39134590
Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis., PMID:39045769
[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation]., PMID:39034804
Bta-miR-200a Regulates Milk Fat Biosynthesis by Targeting IRS2 to Inhibit the PI3K/Akt Signal Pathway in Bovine Mammary Epithelial Cells., PMID:38996051
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
For research use only. Not for human or drug use.
