Catalog No.
YHJ87401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys12-Glu115
Predicted molecular weight
14.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y3M2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARPP-binding protein, PGEA1, CBY1, Protein chibby homolog 1, ARB1, CBY, PIGEA-14, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, C22orf2, Cytosolic leucine-rich protein
Dimerization of the BAR domain-containing protein FAM92A modulates lipid binding and interaction with CBY1., PMID:40484380
The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis., PMID:38197861
Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis., PMID:34446743
CEP164 is essential for efferent duct multiciliogenesis and male fertility., PMID:34085951
A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels., PMID:33934099
DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism., PMID:33811421
Susceptibility of Dermanyssus gallinae from China to acaricides and functional analysis of glutathione S-transferases associated with beta-cypermethrin resistance., PMID:33357546
Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome., PMID:33131181
Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding., PMID:32491167
Combined Chibby and β-Catenin Predicts Clinical Outcomes in Patients with Hepatocellular Carcinoma., PMID:32192213
FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice., PMID:30395363
Chibby is a weak regulator of β-catenin activity in gastric epithelium., PMID:30063079
Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade., PMID:29764469
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation., PMID:29244804
Chibby 1: a new component of β-catenin-signaling in chronic myeloid leukemia., PMID:29152155
Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes., PMID:28107095
BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis., PMID:27528616
Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition., PMID:27082063
14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia., PMID:26147002
Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling., PMID:25909186
The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue., PMID:25869879
Expression of CBY and methylation of CBY at promoter region in human laryngeal squamous cell carcinoma., PMID:25838250
DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia., PMID:25389112
Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression., PMID:25220153
Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells., PMID:25175341
Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function., PMID:25103236
A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib., PMID:24747551
BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia., PMID:24339928
Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: a QCM study based on solid supported membranes., PMID:23838289
Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells., PMID:23707389
No important role for genetic variation in the Chibby gene in monogenic and complex obesity., PMID:23645032
Atonal homolog 1 expression in lung cancer correlates with inhibitors of the Wnt pathway as well as the differentiation and primary tumor stage., PMID:23030416
A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation., PMID:22911743
Characterization of Wnt2 overexpression in a rat granulosa cell line (DC3): effects on CTNNB1 activation., PMID:22517624
The expression patterns and correlations of chibby, β-catenin, and DNA methyltransferase-1 and their clinicopathological significance in lung cancers., PMID:21995627
Generation and characterization of monoclonal antibodies against human Chibby protein., PMID:21529289
Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway., PMID:21182262
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma., PMID:20096688
Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling., PMID:19940019
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac)., PMID:19838061
WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?, PMID:19530245
Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif., PMID:19435523
Real-time quantitative PCR analysis of pediatric ependymomas identifies novel candidate genes including TPR at 1q25 and CHIBBY at 22q12-q13., PMID:18663750
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity., PMID:18573912
The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity., PMID:17905836
Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling., PMID:17403895
Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells., PMID:17261658
Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines., PMID:16570344
TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby., PMID:16424001
Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development., PMID:15737694
For research use only. Not for human or drug use.
