Catalog No.
YHJ86201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu1246-Ser1346
Predicted molecular weight
38.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2I1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
I-1 receptor candidate protein, IR1, I-1, hIRAS, IRAS, Imidazoline receptor 1, Imidazoline-1 receptor, KIAA0975, NISCH, I1R, Imidazoline receptor antisera-selected protein, Imidazoline-1 receptor candidate protein, Nischarin, I1R candidate protein
Nischarin inhibits the epithelial-mesenchymal transition process and angiogenesis in breast cancer cells by inactivating FAK/ERK signaling pathway via EGF like repeats and discoidin domains 3., PMID:39023636
UBTF mediates activation of L3MBTL2 to suppress NISCH expression through histone H2AK119 monoubiquitination modification in breast cancer., PMID:38935187
Clinical significance of downregulated NISCH expression in skin cutaneous melanoma: Modulation of tumor cell invasion, migration, and EMT via PAK1 inhibition., PMID:38723330
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity., PMID:38096048
CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews., PMID:37814412
Nischarin expression may have differing roles in male and female melanoma patients., PMID:37382661
The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions., PMID:35806491
Nischarin Is Not the Functional I1 Imidazoline Receptor Involved in Blood Pressure Regulation., PMID:35485584
Evaluation of neurodevelopmental symptoms in 10 cases of neonatal ichthyosis and sclerosing cholangitis syndrome., PMID:35304779
Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCHΔ5-6 Knockout Mouse Model., PMID:35163298
LncRNA RP11-214F16.8 drives breast cancer tumorigenesis via a post-translational repression on NISCH expression., PMID:35108640
Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer., PMID:35064214
Prenatal exposure to di (2-ethylhexyl) phthalate causes autism-like behavior through inducing Nischarin expression in the mouse offspring., PMID:34781058
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis., PMID:34727954
Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats., PMID:34265418
Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens., PMID:33649389
Impact of Nischarin on EMT regulators in breast cancer cell lines., PMID:33101485
Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling., PMID:33075003
NISCH syndrome: An extremely rare cause of neonatal cholestasis., PMID:32863047
Novel CLDN1 Deletion Associated with Ichthyosis, Sclerosing Cholangitis and Acquired Alopecia., PMID:32424433
Tight Junction Proteins and the Biology of Hepatobiliary Disease., PMID:32012812
Knockout model reveals the role of Nischarin in mammary gland development, breast tumorigenesis and response to metformin treatment., PMID:31525254
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy., PMID:31348885
Disturbance of I1-imidazoline receptor signal transduction in cardiomyocytes of Spontaneously Hypertensive Rats., PMID:31158332
The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence., PMID:30902386
Nischarin attenuates apoptosis induced by oxidative stress in PC12 cells., PMID:30651848
Development of insulin resistance in Nischarin mutant female mice., PMID:30546133
Tight Junction barriers in human hair follicles - role of claudin-1., PMID:30143655
Activation of imidazoline receptor I2, and improved pancreatic β-cell function in human islets., PMID:29996974
Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer., PMID:29912916
Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells., PMID:29415725
[NISCH syndrome, a rare cause of neonatal cholestasis: A case report]., PMID:29146216
A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11., PMID:28970529
Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase., PMID:28842496
A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways., PMID:28806779
Investigation of morin-induced insulin secretion in cultured pancreatic cells., PMID:28699234
Identification of morin as an agonist of imidazoline I-3 receptor for insulin secretion in diabetic rats., PMID:28689255
Upregulation of IRAS/nischarin (I1-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers., PMID:28461172
Effects of I2-imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I1-IR and μ-opioid receptor proteins and modulation of associated signalling pathways., PMID:28342965
Gene-Targeted Next-Generation Sequencing Identifies a Novel CLDN1 Mutation in a Consanguineous Family With NISCH Syndrome., PMID:28154377
Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer., PMID:28131840
Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity., PMID:26670864
Breast Cancer Tumor Suppressors: A Special Emphasis on Novel Protein Nischarin., PMID:26392073
IRAS Modulates Opioid Tolerance and Dependence by Regulating μ Opioid Receptor Trafficking., PMID:26363797
Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs., PMID:26038110
Frequent Loss of NISCH Promotes Tumor Proliferation and Invasion in Ovarian Cancer via Inhibiting the FAK Signal Pathway., PMID:25724667
Expression of integrin-binding protein Nischarin in metastatic breast cancer., PMID:25695373
Canavanine induces insulin release via activation of imidazoline I3 receptors., PMID:25482045
Moxonidine modulates cytokine signalling and effects on cardiac cell viability., PMID:25036265
Novel mutation in the CLDN1 gene in a Turkish family with neonatal ichthyosis sclerosing cholangitis (NISCH) syndrome., PMID:24641442
For research use only. Not for human or drug use.
