Catalog No.
YHJ85601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg21-Leu182
Predicted molecular weight
20.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2B0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Putative secreted protein Zsig9, ZSIG9, MIR-interacting saposin-like protein, CNPY2, Protein canopy homolog 2, Transmembrane protein 4, MSAP, TMEM4
LncRNA ZFAS1 Combined with SRSF1 Regulate CNPY2 Expression and Leads to Microglia Endoplasmic Reticulum Stress-Induced Spinal Cord Injury., PMID:40465066
CNPY2 drives DSS-induced colitis via the macrophage-ROS axis., PMID:40262233
The expression of canopy FGF signaling regulator 2 serves as a diagnostic and prognostic indicator for NSCLC., PMID:39938731
A novel TLR4 accessory molecule drives hepatic oncogenesis through tumor-associated macrophages., PMID:39929433
The role of canopy family proteins: biological mechanism and disease function., PMID:39869231
CNPY2 modulates senescence-associated secretory phenotype in tendon stem/progenitor cells., PMID:39755057
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington's disease., PMID:39359687
Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction., PMID:38804138
Multi-omics in MECP2 duplication syndrome patients and carriers., PMID:38746988
CNPY2 governs PDGF‑BB‑treated vascular smooth muscle cell proliferation, migration and phenotypic transformation via the Akt/mTOR/GSK‑3β signaling pathway., PMID:38544560
Progress in Research on CNPY2 in Diseases., PMID:37259932
The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis., PMID:37103758
Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway., PMID:36422742
[Effects of aerobic exercise on CNPY2-PERK pathway in the liver of mice with non-alcoholic fatty liver disease]., PMID:36062783
Identification and Validation of a Novel Prognostic Gene Model for Colorectal Cancer., PMID:35924107
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway., PMID:35278877
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress., PMID:34992238
Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53., PMID:34986508
LncRNA LINC00342 promotes gastric cancer progression by targeting the miR-545-5p/CNPY2 axis., PMID:34715819
MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2., PMID:34657557
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis., PMID:34298825
Canopy Fibroblast Growth Factor Signaling Regulator 2 (CNPY2) Inhibits Neuron Apoptosis in Parkinson's Disease via the AKT/GSK3β Pathway., PMID:34060992
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway., PMID:33995012
Hypoxia-induced CNPY2 upregulation promotes glycolysis in cervical cancer through activation of AKT pathway., PMID:33721832
Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression., PMID:33482578
miR‑30a‑3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2., PMID:31894275
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling., PMID:31625681
Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury., PMID:31396081
Characterization of CNPY5 and its family members., PMID:31050855
Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair., PMID:31047986
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway., PMID:30864682
Canopy Homolog 2 Expression Predicts Poor Prognosis in Hepatocellular Carcinoma with Tumor Hemorrhage., PMID:30415246
Serum CNPY2 isoform 2 represents a novel biomarker for early detection of colorectal cancer., PMID:30070972
CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer., PMID:29864955
A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis., PMID:29849941
CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells., PMID:29707137
The CNPY2 enhances epithelial-mesenchymal transition via activating the AKT/GSK3β pathway in non-small cell lung cancer., PMID:29569784
Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis., PMID:29135454
Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis., PMID:29037440
CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response., PMID:28869608
A decision tree-based combination of ezrin-interacting proteins to estimate the prognostic risk of patients with esophageal squamous cell carcinoma., PMID:28603065
CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53., PMID:28235487
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma., PMID:28212443
Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium., PMID:27696085
Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway., PMID:26835537
Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy., PMID:26160001
A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation., PMID:25589425
Expression of CNPY2 in mouse tissues: quantification and localization., PMID:25393402
A genetic screen in Drosophila for regulators of human prostate cancer progression., PMID:25117438
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)., PMID:22378787
For research use only. Not for human or drug use.
