Catalog No.
YHJ84901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu162-Ala312
Predicted molecular weight
19.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y263
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLAP, PLA2P, Phospholipase A-2-activating protein, PLAA
Targets and Potential Mechanism of Chondroitin Sulfate A-selenium Nanoparticle on Kashin-Beck Disease Chondrocytes., PMID:40138104
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival., PMID:39744815
Identification of the effects of hypoxia on the liver tissues of Nile tilapia Oreochromis Niloticus., PMID:39379813
Allelic heterogeneity and abnormal vesicle recycling in PLAA-related neurodevelopmental disorders., PMID:38650658
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy., PMID:38183492
Molecular and biotechnological characteristics of proteolytic activity from Streptococcus thermophilus as a proteolytic lactic acid bacteria to enhance protein-derived bioactive peptides., PMID:38173974
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA., PMID:38130174
Tools and mechanisms of vacuolar escape leading to host egress in Legionella pneumophila infection: Emphasis on bacterial phospholipases., PMID:37891705
p97/VCP Promotes the Recycling of Endocytic Cargo., PMID:37756124
Phosphatase A1 accessory protein PlaS from Serratia marcescens controls cell membrane permeability, fluidity, hydrophobicity, and fatty acid composition in Escherichia coli BL21., PMID:37699461
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization., PMID:37211156
Heterologous Expression of Plantaricin 423 and Mundticin ST4SA in Saccharomyces cerevisiae., PMID:37171691
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805., PMID:36300783
The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle., PMID:36278411
mRNA Capture Sequencing and RT-qPCR for the Detection of Pathognomonic, Novel, and Secondary Fusion Transcripts in FFPE Tissue: A Sarcoma Showcase., PMID:36232302
Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats., PMID:36152882
PLAA suppresses ovarian cancer metastasis via METTL3-mediated m6A modification of TRPC3 mRNA., PMID:35869392
Post-translational site-specific protein azidolation with an azido pyridoxal derivative., PMID:35695118
Manganese Privation-Induced Transcriptional Upregulation of the Class IIa Bacteriocin Plantaricin 423 in Lactobacillus plantarum Strain 423., PMID:34406833
The phospholipase A effector PlaA from Legionella pneumophila: expression, purification and crystallization., PMID:32133999
High-Level Production of Bacteriotoxic Phospholipase A1 in Bacterial Host Pseudomonas fluorescens Via ABC Transporter-Mediated Secretion and Inducible Expression., PMID:32053917
Wide-Range Effects of 1,25(OH)2D3 on Group 4A Phospholipases Is Related to Nuclear Factor κ-B and Phospholipase-A2 Activating Protein Activity in Mast Cells., PMID:31707382
Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies in China caused by novel mutations of PLAA., PMID:31322726
Detection of selection signatures for agonistic behaviour in cattle., PMID:29700853
Disulfide loop cleavage of Legionella pneumophila PlaA boosts lysophospholipase A activity., PMID:29176577
Lessons Learned and to Be Learned About the Use of N-Terminal Pro-B-Type Natriuretic Peptide in Heart Failure and Atrial Fibrillation., PMID:29018175
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins., PMID:28413018
Comparative genomic analysis of bacteriocin-producing Weissella cibaria 110., PMID:28058448
Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy., PMID:28007986
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy., PMID:27753622
Computational modeling of Repeat1 region of INI1/hSNF5: An evolutionary link with ubiquitin., PMID:27261671
Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery., PMID:26301700
Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique., PMID:26287192
A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling., PMID:25845934
[The association of polymorphisms in SLC18A1, TPH1 and RELN genes with risk of paranoid schizophrenia]., PMID:25842846
Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)/calmodulin-dependent protein kinase II., PMID:25448737
Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cells., PMID:25263660
Rapid 1α,25(OH)₂D ₃ membrane-mediated activation of Ca²⁺/calmodulin-dependent protein kinase II in growth plate chondrocytes requires Pdia3, PLAA and caveolae., PMID:25158196
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly., PMID:25034784
Signaling components of the 1α,25(OH)2D3-dependent Pdia3 receptor complex are required for Wnt5a calcium-dependent signaling., PMID:24946135
New insights on membrane mediated effects of 1α,25-dihydroxy vitamin D3 signaling in the musculoskeletal system., PMID:24291576
Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1α,25(OH)(2)D(3)., PMID:23896121
Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-estradiol involves differential regulation of plasma membrane associated estrogen receptors., PMID:23305904
Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction., PMID:23201116
miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression., PMID:22846677
Zinc metalloproteinase ProA directly activates Legionella pneumophila PlaC glycerophospholipid:cholesterol acyltransferase., PMID:22582391
Mechanism of Pdia3-dependent 1α,25-dihydroxy vitamin D3 signaling in musculoskeletal cells., PMID:22569272
Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3., PMID:22484374
The protein SdhA maintains the integrity of the Legionella-containing vacuole., PMID:22308473
Unexpected depletion of plasma arachidonate and total protein in cats fed a low arachidonic acid diet due to peroxidation., PMID:22005409
For research use only. Not for human or drug use.
