Catalog No.
YHJ84701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln34-Arg115
Predicted molecular weight
11.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y251
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hpa1, HPA1, Heparanase-1, HSE1, HEP, Heparanase, Endo-glucoronidase, HPSE1, HPA, HPR1, HPSE
Could Hydrophobicity of Sulfated Pseudo-Trisaccharides Derived from Repurposing Aminoglycoside Tobramycin Modulate the Enzymatic Activity of Heparanase?, PMID:40500735
Targeting Heparanase Attenuates Podocyte Injury Induced by Puromycin Aminonucleoside., PMID:40495439
Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition., PMID:40487608
Curcumin protects extracellular matrix to maintain microenvironmental stability inhibiting colon cancer metastasis through HPSE/IL-6/STAT5 axis., PMID:40464979
Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1/NF-κB/HPSE pathway., PMID:40441470
Design of Paromomycin and Neomycin as Sulfated and Hydrophobic Glycans to Target Heparanase-Driven Tumor Progression and Metastasis., PMID:40436739
Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands., PMID:40424780
Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS., PMID:40408331
Computational and Experimental Investigation of Antidiabetic Drugs on Tofacitinib Metabolism: Molecular Docking, in vitro, and in vivo Studies., PMID:40386187
Transient Inflammation of Pancreatic Exocrine Tissue in Autoimmune Diabetes Follows Onset of Islet Damage and Utilizes Heparanase-1., PMID:40362360
Prediction of newly synthesized heparin mimic's effects as heparanase inhibitor in cancer treatments via variational quantum neural networks., PMID:40267546
Effect of bone marrow blood versus peripheral blood on the hemostatic balance of osteoblasts and endothelial cells., PMID:40258877
Study on Heparanase Promoting Breast Cancer Cell Proliferation and Inhibiting NK Cell Cytolytic Activity Via the PD-1/PD-L1 Pathway., PMID:40253275
Integrated quantitative proteomics and phosphoproteomics analysis reveals USP46-POU4F1-HPSE signaling axis in the pathogenesis of Hirschsprung disease., PMID:40251903
Maculopathy after long-term use of fondaparinux, a heparin mimetic and heparanase inhibitor., PMID:40230456
GRHL3 specifically initiated by the TP63 transcription factor promotes the metastasis of squamous cell carcinogenesis., PMID:40199449
A Novel Series of Synthetic Heparin-Mimetics-Itaconic Acid-Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis., PMID:40192620
Multi-omics insights into the roles of CCNB1, PLK1, and HPSE in breast cancer progression: implications for prognosis and immunotherapy., PMID:40186712
Heparanase inhibition mitigates bleomycin-induced pulmonary fibrosis in mice by reducing M2 macrophage polarization., PMID:40180131
Structure identification and biological activity of a novel sulfated glycosaminoglycan-like polysaccharide from Sepia recurvirostra ink., PMID:40158962
Expanding the Role of Heparin Derivatives in Oncology: From Anticoagulation to Antitumor Activity., PMID:40143176
Poly[(N-acryloyl glycine)-co-(acrylamide)]-induced cell growth inhibition in heparanase-driven malignancies., PMID:40067314
Identification of biomarkers and potential drug targets for esophageal cancer: a Mendelian randomization study., PMID:40059241
Unique structure and biological properties of fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber Holothuria floridana., PMID:40037731
Leukemia inhibitory factor in peripheral blood as a prognostic marker in breast cancer., PMID:40023004
HPSE-mediated proinflammatory signaling contributes to neurobehavioral deficits following intranasal HSV-1 infection., PMID:40013778
Heparanase, a host gene that potently restricts retrovirus transcription., PMID:39998209
The modulation of endothelial glycocalyx by sulodexide on the porcine model of enzymatic endothelial glycocalyx damage - a pilot study., PMID:39973431
Correction: Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization., PMID:39948089
Current understanding of heparanase 2 regulation, a non-heparanase., PMID:39910799
Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses., PMID:39859197
Extracellular matrix components in preeclampsia., PMID:39798685
Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate., PMID:39772142
Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation., PMID:39766213
Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity., PMID:39742858
Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury., PMID:39721014
Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization., PMID:39695102
An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells., PMID:39651893
Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension., PMID:39609799
Significant Advancements and Evolutions in Chimeric Antigen Receptor Design., PMID:39596267
Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice., PMID:39587144
The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer., PMID:39506780
Heparanase-induced endothelial glycocalyx degradation exacerbates lung ischemia/reperfusion injury in male mice., PMID:39448392
Fine mapping and identification of candidate genes associated with powdery mildew resistance in melon (Cucumis melo L.)., PMID:39411005
Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection., PMID:39373347
Mast cell heparanase promotes breast cancer stem-like features via MUC1/estrogen receptor axis., PMID:39349458
Effect of chronic periodontitis on the endothelial glycocalyx of rat penile corpus cavernosum., PMID:39287569
Involvement of heparanase in the pathogenesis of acute pancreatitis: Implication of novel therapeutic approaches., PMID:39248454
Analysis of Expression Pattern and Prognostic Value of the Heparanase in Breast Cancer Through CD274/CTLA-4 Immune Checkpoint Proteins., PMID:39248214
A tellurium-based small compound ameliorates tumor metastasis by downregulating heparanase expression., PMID:39247596
For research use only. Not for human or drug use.
