Catalog No.
YHJ83701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr335-Ser561
Predicted molecular weight
27.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UQQ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lymphocyte-specific adapter protein Lnk, SH2B3, Signal transduction protein Lnk, LNK, Lymphocyte adapter protein, SH2B adapter protein 3
Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response., PMID:40428397
The Ubiquitination and Degradation of SH2B3 Mediated by MEF2A/WWP2 Axis Restores Microglial Homeostasis to Alleviate Cerebral Microvascular Endothelial Cell Injury in Ischemic Stroke., PMID:40407948
Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance., PMID:40048557
Dissecting the genetic basis and mechanisms underlying the associations between multiple extrahepatic factors and autoimmune liver diseases., PMID:39741931
Six genetic variants are associated with cardiovascular disease independently from canonical risk factors: a new method to refine GWAS results based on the UKBiobank phenotype database., PMID:39704901
Donor selection for allogeneic hematopoietic cell transplant in a patient with JAK2 V617F primary myelofibrosis and SH2B3/LNK germline variant., PMID:39672944
FABIO: TWAS fine-mapping to prioritize causal genes for binary traits., PMID:39621803
[Childhood acute lymphoblastic leukemia with CREBBP gene mutation: a clinical analysis of 14 cases]., PMID:39587751
LNK/SH2B3 Loss Exacerbates the Development of Myeloproliferative Neoplasms in CBL-deficient Mice., PMID:39560864
Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci., PMID:39505854
Clinical and genetic profile of Chinese patients with indolent natural killer-cell lymphoproliferative disorder of the gastrointestinal tract., PMID:39276532
[Genetic Variation of SH2B3 in Patients with Myeloid Neoplasms]., PMID:39192417
Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia., PMID:39119725
Novel genetic association between obesity, colorectal cancer, and inflammatory bowel disease., PMID:38932827
Null-type SH2B3 mutations are potential drivers in a subset of Ph-negative myeloproliferative neoplasms., PMID:38924136
Negative regulation of SH2B3 by SMYD5 controls epithelial-mesenchymal transition in lung cancer., PMID:38723947
Clinical laboratory characteristics and gene mutation spectrum of Ph-negative MPN patients with atypical variants of JAK2, MPL, or CALR., PMID:38618943
SH2B3 alterations in a novel genetic condition, juvenile myelomonocytic leukemia, and myeloproliferative neoplasia., PMID:38618667
Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience., PMID:38568469
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age., PMID:38484896
A multi-ancestry genome-wide association study in type 1 diabetes., PMID:38453145
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity., PMID:38417019
Tyrosine kinase inhibitor resistance in de novo BCR::ABL1-positive BCP-ALL beyond kinase domain mutations., PMID:38386975
LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation., PMID:38377486
Genotypes predisposing for celiac disease and autoimmune diabetes and risk of infections in early childhood., PMID:38374560
Protein-protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis., PMID:38326862
Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata., PMID:38292771
Mapping inherited genetic variation with opposite effects on autoimmune disease and cancer identifies candidate drug targets associated with the anti-tumor immune response., PMID:38234717
LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia., PMID:38152053
DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved., PMID:38139431
STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient., PMID:38135698
Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis., PMID:38096361
Germline heterozygous SH2B3-mutations and (idiopathic) erythrocytosis: Detection of a previously undescribed mutation., PMID:38024597
Germline bi-allelic SH2B3/LNK alteration predisposes to a neonatal juvenile myelomonocytic leukemia-like disorder., PMID:37981895
Polycystic Ovary Syndrome Physiologic Pathways Implicated Through Clustering of Genetic Loci., PMID:37967238
Genomic Mutation Profiles of Patients with Acute Myeloid Leukemia in Korea: a Single-Center Experience., PMID:37948498
Genomic alterations in blast phase of BCR::ABL1-negative myeloproliferative neoplasms., PMID:37867386
Systemic aspergillosis in a patient with interferon gamma receptor 1 deficiency; a case report., PMID:37277724
Integration of Mendelian randomisation and systems biology models to identify novel blood-based biomarkers for stroke., PMID:36958462
Acquired uniparental isodisomies involving chromosome 12 in paediatric B-cell precursor acute lymphoblastic leukaemia: Associations with chromosome 21 gains and SH2B3 mutations., PMID:36899493
Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots., PMID:36792583
Molecular analysis of phenotypic heterogeneity in JAK2V617F-positive myeloproliferative neoplasms reveals a potential target for therapy., PMID:36708268
Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort., PMID:36651163
Src homology 2-B adapter protein 3 C784 T and Methylenetetrahydrofolate reductase C677 T Polymorphisms and Inflammation Markers in ST-segment Elevation Myocardial Infarction Patients., PMID:36650025
CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients., PMID:36622793
Exploring potential shared genetic influences between rheumatoid arthritis and blood lipid levels., PMID:36455308
Coronary artery disease risk factors affected by RNA modification-related genetic variants., PMID:36204584
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage., PMID:36169218
Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study., PMID:36150053
Immune dysregulation associated with co-occurring germline CBL and SH2B3 variants., PMID:36123612
For research use only. Not for human or drug use.
