Catalog No.
YHJ83601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe681-Ser1087
Predicted molecular weight
46.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UQL6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone deacetylase 5, HDAC5, HD5, KIAA0600, Antigen NY-CO-9
Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder., PMID:40504297
VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation., PMID:40494210
Betulinic acid enhances autopahgy to promote microglial M2 polarization and alleviate inflammation via AMPK-HDAC5-KLF2 signaling pathways in spinal cord injury., PMID:40388862
HBP-A Attenuates Knee Osteoarthritis Progression via MLK3/P38/HDAC4 Axis-Mediated Dual Protection of Articular Cartilage and Quadriceps., PMID:40318007
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment., PMID:40265153
Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenström macroglobulinaemia., PMID:40254718
SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis., PMID:40250791
H1.0 modulates IL-6 expression and paclitaxel resistance via HDAC5 in ovarian cancer cells., PMID:40112929
The Impact of Tartrazine on DNA Methylation, Histone Deacetylation, and Genomic Stability in Human Cell Lines., PMID:40077783
NUPR1 contributes to endocrine therapy resistance by modulating BIRC5 expression and inducing luminal B-ERBB2+ subtype-like characteristics in estrogen receptor-positive breast cancer cells., PMID:39991577
Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression., PMID:39915556
HDAC4 regulates apoptosis in Acan-CreERT2;HDAC4d /d mice with osteoarthritis by downregulating ATF4., PMID:39895575
Leptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription., PMID:39875704
The class-IIa HDAC inhibitor TMP269 promotes BMP-Smad signalling and is neuroprotective in in vitro and in vivo 6-hydroxydopamine models of Parkinson's disease., PMID:39842624
Acetylation-enhanced Sp1 transcriptional activity suppresses Mlph expression., PMID:39824975
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts., PMID:39800758
Unraveling the mechanism of microRNA-134 in colon cancer progression: Targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation., PMID:39746598
Transcriptional regulation of daily sleep amount by TCF4-HDAC4-CREB complex in mice., PMID:39745887
Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway., PMID:39732306
Acetylation of E2F1 at K125 facilitates cell apoptosis under serum stress., PMID:39731810
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways., PMID:39694936
OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis., PMID:39659899
CRISPR activation identifies a novel miR-2861 binding site that facilitates the osteogenesis of human mesenchymal stem cells., PMID:39506798
Loss of Hdac4 in osteoprogenitors impairs postnatal trabecular and cortical bone formation, resulting in a dwarfism and osteopenia phenotype in mice., PMID:39481602
Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis., PMID:39464736
Temporal regulation of acetylation status determines PARP1 role in DNA damage response and metabolic homeostasis., PMID:39423262
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway., PMID:39379699
Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia., PMID:39362994
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice., PMID:39304061
A novel dual-epigenetic inhibitor enhances recombinant monoclonal antibody expression in CHO cells., PMID:39292268
Gene Expression Levels Related to Histone Acetylation are Altered in Parkinson Disease Patients., PMID:39258138
HDAC5 deacetylates c-Myc and facilitates cell cycle progression in hepatocellular carcinoma cells., PMID:39243916
LMK-235 suppresses osteoclastogenesis and promotes osteoblastogenesis by inhibiting HDAC4., PMID:39198677
Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in Depression., PMID:39190549
Suppressed testicular macrophage M1 polarization by HDAC5 enforces insensitivity to LPS-elicited blood-testis barrier damage., PMID:39151879
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate., PMID:39136693
Hippocampal HDAC5-mediated histone acetylation underlies stress susceptibility in mice exposed to chronic social defeat stress., PMID:39127342
Role of HDAC5 Epigenetics in Chronic Craniofacial Neuropathic Pain., PMID:38999998
Exploration of effective biomarkers for venous thrombosis embolism in Behçet's disease based on comprehensive bioinformatics analysis., PMID:38987624
Epigenetics., PMID:38884720
Expression of glucocorticoid receptor and HDACs in airway smooth muscle cells is associated with response to steroids in COPD., PMID:38812021
Antidepressant effect and mechanism of TMP269 on stress-induced depressive-like behavior in mice., PMID:38801927
Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis., PMID:38776988
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I., PMID:38769542
mPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition., PMID:38760744
Post-translational modification-dependent oligomerization switch in regulation of global transcription and DNA damage repair during genotoxic stress., PMID:38750015
A consortium of Hordeum vulgare and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis., PMID:38687561
Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats., PMID:38681576
KN-93 promotes HDAC4 nucleus translocation to promote fatty acid oxidation in myocardial infarction., PMID:38663474
Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation., PMID:38657041
For research use only. Not for human or drug use.
