Catalog No.
YMJ83101
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Val1346-Ser1530
Predicted molecular weight
22.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9EQZ7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RAB3IP3, Regulating synaptic membrane exocytosis protein 2, KIAA0751, Rab-3-interacting molecule 2, RIMS2, RIM 2, RIM2, Rab-3-interacting protein 3
Genome-wide association analysis reveals genetic loci and candidate genes for white diarrhea in Jingyuan chickens., PMID:39951879
Worldwide study of the taste of bitter medicines and their modifiers., PMID:39902731
Genetic analyses of a large consanguineous south Indian family reveal novel variants in NAGPA and four hitherto unreported genes in developmental stuttering., PMID:39382170
Autozygome-guided exome-first study in a consanguineous cohort with early-onset retinal disease uncovers an isolated RIMS2 phenotype and a retina-enriched RIMS2 isoform., PMID:38468396
Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice., PMID:38218585
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease., PMID:38012808
Aberrant methylation in neurofunctional gene serves as a hallmark of tumorigenesis and progression in colorectal cancer., PMID:37020199
Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum., PMID:36970523
Pathways Activated by Infected and Bystander Chondrocytes in Response to Ross River Virus Infection., PMID:36680176
Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder., PMID:35893077
Genome-Wide Association Study of Potential Meat Quality Trait Loci in Ducks., PMID:35741748
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles., PMID:35472162
Multi-omics analyses provide novel biological insights to distinguish lobular ductal types of invasive breast cancers., PMID:35348974
Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses., PMID:34211824
Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease., PMID:34101221
Binding of Ca2+-independent C2 domains to lipid membranes: A multi-scale molecular dynamics study., PMID:34081910
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease., PMID:33958783
In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study., PMID:33879671
Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis., PMID:33413076
Congenital stationary night blindness: an update and review of the disease spectrum in Saudi Arabia., PMID:33369259
A miRNA-clinicopathological nomogram for the prediction of central lymph node metastasis in papillary thyroid carcinoma-analysis from TCGA database., PMID:32871952
Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement., PMID:32470375
Identification of Novel Targets of RBM5 in the Healthy and Injured Brain., PMID:32335213
Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma., PMID:32241263
Single-Nucleotide Polymorphisms Associated with the Senescence-Accelerated Phenotype of OXYS Rats: A Focus on Alzheimer's Disease-Like and Age-Related-Macular-Degeneration-Like Pathologies., PMID:31929160
Quantification of trans-synaptic protein alignment: A data analysis case for single-molecule localization microscopy., PMID:31325491
Age-related gene and miRNA expression changes in airways of healthy individuals., PMID:30842487
Afadin cooperates with Claudin-2 to promote breast cancer metastasis., PMID:30692208
Cone-rod homeobox CRX controls presynaptic active zone formation in photoreceptors of mammalian retina., PMID:30084954
C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins., PMID:28377503
Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease., PMID:28118666
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs., PMID:27537484
RIM genes differentially contribute to organizing presynaptic release sites., PMID:22753485
RIM, Munc13, and Rab3A interplay in acrosomal exocytosis., PMID:22248876
Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A., PMID:22147008
Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction., PMID:20520587
Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels., PMID:19878533
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells., PMID:19509185
Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism., PMID:19199833
Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs., PMID:18490030
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release., PMID:17124501
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch., PMID:16732694
ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells., PMID:16716196
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution., PMID:16216076
Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries., PMID:14621295
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2., PMID:12578829
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis., PMID:12401793
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion., PMID:11598134
cAMP-GEFII is a direct target of cAMP in regulated exocytosis., PMID:11056535
The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins., PMID:10748113
For research use only. Not for human or drug use.
