Catalog No.
YHJ82901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln277
Predicted molecular weight
34.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UPZ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ciliogenesis associated kinase 1, Serine/threonine-protein kinase ICK, MAK-related kinase, ICK, KIAA0936, hICK, Laryngeal cancer kinase 2, CILK1, MRK, LCK2, Intestinal cell kinase
DYF-5 regulates intraflagellar transport by affecting train turnaround., PMID:40072497
An Epilepsy-Associated CILK1 Variant Compromises KATNIP Regulation and Impairs Primary Cilia and Hedgehog Signaling., PMID:39120290
Transcriptome Analysis in Air-Liquid Interface Porcine Respiratory Epithelial Cell Cultures Reveals That the Betacoronavirus Porcine Encephalomyelitis Hemagglutinating Virus Induces a Robust Interferon Response to Infection., PMID:38932231
An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling., PMID:38798407
Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1., PMID:38725848
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia., PMID:38452767
The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia., PMID:37665596
Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates., PMID:36147669
Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms., PMID:36063999
KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease., PMID:35961787
Modulation of Primary Cilia by Alvocidib Inhibition of CILK1., PMID:35897693
Molecular basis underlying the ciliary defects caused by IFT52 variations found in skeletal ciliopathies., PMID:35704471
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1., PMID:35609210
The carboxyl-terminal region of SDCCAG8 comprises a functional module essential for cilia formation as well as organ development and homeostasis., PMID:35131266
Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation., PMID:34893605
CCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32., PMID:34624068
Mice Harboring a Non-Functional CILK1/ICK Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant CILK1/ICK., PMID:34445580
CDKL kinase regulates the length of the ciliary proximal segment., PMID:33857430
Post-translational modification enzymes as key regulators of ciliary protein trafficking., PMID:33681987
Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models., PMID:33382037
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function., PMID:32935890
Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking., PMID:32732286
Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy., PMID:32178256
Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome., PMID:31662288
Ciliogenesis associated kinase 1: targets and functions in various organ systems., PMID:31506943
Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis., PMID:31277411
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase., PMID:30782830
Enriched expression of the ciliopathy gene Ick in cell proliferating regions of adult mice., PMID:29635032
Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy., PMID:29539279
Modulation of GSK3β autoinhibition by Thr-7 and Thr-8., PMID:29377106
A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development., PMID:29098359
Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome., PMID:29030113
An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome., PMID:28380258
Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function., PMID:28115485
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets., PMID:27503210
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome., PMID:27466187
MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease., PMID:25565137
Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition., PMID:25184386
Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling., PMID:24853502
Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity., PMID:24244486
CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner., PMID:23743448
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion., PMID:23319595
Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908., PMID:22356909
Diagnostic biomarkers of prostate cancer., PMID:21034352
The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors., PMID:20459822
Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells., PMID:19696144
A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems., PMID:19185282
STAT5 contributes to antiapoptosis in melanoma., PMID:19011510
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase., PMID:16954377
Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase., PMID:15988018
For research use only. Not for human or drug use.
